O43781 | DYRK3_HUMAN | Dual specificity tyrosine-phosphorylation-regulated kinase 3 (DYRK3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 209~522 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4546504 |  |
IC50 | = | 0.104 | nM | 555.99 | C[C@@H](Oc1cc(C(=O)N(C)C)ccc1Nc1nc(O[C@H]2CC[C@@](C)(O)CC2)c2c(Cl)c[nH]c2n1)C(F)(F)F | Homo sapiens | CHEMBL4349105 | assay format |
| CHEMBL5422486 |  |
IC50 | = | 2.0 | nM | 432.47 | O=C1NC(NC23CC4(F)CC(F)(CC(F)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 | Homo sapiens | CHEMBL5363961 | single protein format |
| CHEMBL5404416 |  |
IC50 | = | 10.0 | nM | 361.45 | O=C1NC(NC23CC4CC(CC(C4)C2)C3)=N/C1=C\c1ccc2[nH]cnc2c1 | Homo sapiens | CHEMBL5363961 | single protein format |
| CHEMBL5416942 |  |
IC50 | = | 10.0 | nM | 407.47 | COc1ccc(/C=C2\N=C(Nc3ccc(N4CCN(C)CC4)cc3)NC2=O)cc1O | Homo sapiens | CHEMBL5363961 | single protein format |
| CHEMBL5200518 |  |
IC50 | = | 10.0 | nM | 407.47 | COc1cc(/C=C2\N=C(Nc3ccc(N4CCN(C)CC4)cc3)NC2=O)ccc1O | Homo sapiens | CHEMBL5127383 | assay format |
| CHEMBL393525 |  |
IC50 | = | 10.4 | nM | 452.29 | Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)N(C)/N=C/c1cnc2ccc(Br)cn12 | Homo sapiens | CHEMBL5251372 | cell-based format |
| CHEMBL5438158 |  |
IC50 | = | 12.0 | nM | 396.49 | O=C1NC(NC23CC4CC(CC(F)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 | Homo sapiens | CHEMBL5363961 | single protein format |
| CHEMBL5405059 |  |
IC50 | = | 14.0 | nM | 394.5 | O=C1NC(NC23CC4CC(CC(O)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 | Homo sapiens | CHEMBL5363961 | single protein format |
| CHEMBL5414801 |  |
IC50 | = | 14.0 | nM | 419.49 | CN1CCN(c2ccc(NC3=N/C(=C\c4ccc5c(c4)OCCO5)C(=O)N3)cc2)CC1 | Homo sapiens | CHEMBL5363961 | single protein format |
| CHEMBL5195216 |  |
IC50 | = | 14.0 | nM | 417.47 | CN1CCN(c2ccc(NC3=N/C(=C\C4=COc5ccccc5O4)C(=O)N3)cc2)CC1 | Homo sapiens | CHEMBL5127383 | assay format |
| CHEMBL5412565 |  |
IC50 | = | 16.0 | nM | 421.57 | CN(C)C12CC3CC(CC(NC4=N/C(=C\c5ccc6ncsc6c5)C(=O)N4)(C3)C1)C2 | Homo sapiens | CHEMBL5363961 | single protein format |
| CHEMBL5091238 |  |
IC50 | = | 19.83 | nM | 378.5 | O=C1NC(NC23CC4CC(CC(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 | Homo sapiens | CHEMBL5251372 | cell-based format |
| CHEMBL3301610 |  |
IC50 | = | 20.6 | nM | 506.61 | CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1 | Homo sapiens | CHEMBL5251372 | cell-based format |
| CHEMBL3894571 |  |
IC50 | = | 21.1 | nM | 383.41 | COC(=N)c1nc2ccc3ncnc(Nc4ccc(OC)cc4F)c3c2s1 | Homo sapiens | CHEMBL4719514 | single protein format |
| CHEMBL5422654 |  |
IC50 | = | 22.0 | nM | 435.55 | CC(=O)NC12CC3CC(C1)CC(NC1=N/C(=C\c4ccc5ncsc5c4)C(=O)N1)(C3)C2 | Homo sapiens | CHEMBL5363961 | single protein format |
| CHEMBL5081787 |  |
IC50 | = | 22.7 | nM | 401.28 | O=C1N=C(Nc2c(Cl)cccc2Cl)S/C1=C\c1ccc2nccnc2c1 | Homo sapiens | CHEMBL5251372 | cell-based format |
| CHEMBL5279705 |  |
IC50 | = | 23.5 | nM | 311.34 | COC1=CC2C(=O)NC3=Cc4ccc(OC)cc4C(=C1OC)C32 | Homo sapiens | CHEMBL5251372 | cell-based format |
| CHEMBL5409574 |  |
IC50 | = | 24.0 | nM | 471.61 | CS(=O)(=O)NC12CC3CC(CC(NC4=N/C(=C\c5ccc6ncsc6c5)C(=O)N4)(C3)C1)C2 | Homo sapiens | CHEMBL5363961 | single protein format |
| CHEMBL5417147 |  |
IC50 | = | 24.0 | nM | 408.53 | COC12CC3CC(CC(NC4=N/C(=C\c5ccc6ncsc6c5)C(=O)N4)(C3)C1)C2 | Homo sapiens | CHEMBL5363961 | single protein format |
| CHEMBL5418722 |  |
IC50 | = | 24.0 | nM | 461.59 | O=C1NC(NC23CC4CC(CC(NC(=O)C5CC5)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 | Homo sapiens | CHEMBL5363961 | single protein format |