O43683 | BUB1_HUMAN | Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 790~1004 | |
| PF08311 | Mad3_BUB1_I - Mad3/BUB1 homology region 1 | 8~126 |
3D structures mapped by conservation among orthologs
[ Domain: "ARM repeat" // Mad3_BUB1_I ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3260324 |  |
IC50 | = | 5.0 | nM | 478.5 | CCOc1cc(F)c(Cn2nc(-c3ncc(OC)c(Nc4ccncc4)n3)c3c2CCC3)c(F)c1 | Homo sapiens | CHEMBL3271320 | single protein format |
| CHEMBL3260326 |  |
IC50 | = | 6.0 | nM | 564.59 | CCOc1cc(F)c(Cn2nc(-c3ncc(OCC4(CO)COC4)c(Nc4ccncc4)n3)c3c2CCC3)c(F)c1 | Homo sapiens | CHEMBL3271320 | single protein format |
| CHEMBL5084426 |  |
IC50 | = | 6.5 | nM | 534.52 | COc1cnccc1Nc1nc(-c2nn(Cc3c(F)cc(OCCO)cc3F)c3ccccc23)ncc1OC | Homo sapiens | CHEMBL5059577 | single protein format |
| CHEMBL3260325 |  |
IC50 | = | 9.0 | nM | 535.6 | CCOc1cc(F)c(Cn2nc(-c3ncc(OCCN(C)C)c(Nc4ccncc4)n3)c3c2CCC3)c(F)c1 | Homo sapiens | CHEMBL3271320 | single protein format |
| CHEMBL3260329 |  |
IC50 | = | 30.0 | nM | 551.6 | CS(=O)(=O)CCOc1cnc(-c2nn(Cc3ccccc3F)c3c2CCC3)nc1Nc1ccncc1C(N)=O | Homo sapiens | CHEMBL3271320 | single protein format |