O43614 | OX2R_HUMAN | Orexin receptor type 2 (HCRTR2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 71~364 | |
| PF03827 | Orexin_rec2 - Orexin receptor type 2 | 387~444 |
3D structures mapped by conservation among orthologs
[ Domain: "Family A G protein-coupled receptor-like" // 7tm_1_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3946821 |  |
IC50 | = | 1.0 | nM | 446.49 | Cc1ccc(-n2nccn2)c(C(=O)N2CCCOC2Cn2cc(-c3ccc(F)cc3)cn2)c1 | Homo sapiens | CHEMBL3888032 | assay format |
| CHEMBL3944494 |  |
IC50 | = | 1.0 | nM | 457.51 | Cc1ccc(-c2ncccn2)c(C(=O)N2CCCOC2Cn2ccc(-c3ccc(F)cc3)n2)c1 | Homo sapiens | CHEMBL3888032 | assay format |
| CHEMBL3985942 |  |
IC50 | = | 1.2 | nM | 447.47 | Cc1ccc(-n2nccn2)c(C(=O)N2CCCOC2Cn2ccc(-c3ccc(F)cn3)n2)c1 | Homo sapiens | CHEMBL3888032 | assay format |
| CHEMBL3978354 |  |
IC50 | = | 1.2 | nM | 458.5 | Cc1ccc(-c2ncccn2)c(C(=O)N2CCCOC2Cn2ccc(-c3ccc(F)cc3)n2)n1 | Homo sapiens | CHEMBL3888032 | assay format |
| CHEMBL3920093 |  |
IC50 | = | 1.4 | nM | 461.5 | Cc1ccc(-n2nccn2)c(C(=O)N2CC(C)COC2Cn2cc(-c3ccc(F)cn3)cn2)c1 | Homo sapiens | CHEMBL3888032 | assay format |
| CHEMBL3930099 |  |
IC50 | = | 1.7 | nM | 448.46 | Cc1ccc(-n2nccn2)c(C(=O)N2CCCOC2Cc2noc(-c3ccc(F)cc3)n2)c1 | Homo sapiens | CHEMBL3888032 | assay format |
| CHEMBL3895270 |  |
IC50 | = | 2.0 | nM | 441.49 | COc1ccc2[nH]cc(CCn3cc(NC(=O)c4ncoc4-c4cccc(C)c4)cn3)c2c1 | Homo sapiens | CHEMBL3888294 | assay format |
| CHEMBL3922489 |  |
IC50 | = | 2.0 | nM | 461.91 | COc1ccc2[nH]cc(CCn3cc(NC(=O)c4ncoc4-c4cccc(Cl)c4)cn3)c2c1 | Homo sapiens | CHEMBL3888294 | assay format |
| CHEMBL3943607 |  |
IC50 | = | 2.0 | nM | 427.46 | COc1ccc2[nH]cc(CCn3cc(NC(=O)c4ncoc4-c4ccccc4)cn3)c2c1 | Homo sapiens | CHEMBL3888294 | assay format |
| CHEMBL2385132 |  |
IC50 | = | 2.0 | nM | 454.55 | CCN(Cc1cccnc1)C(=O)CN(c1ccc(OC)nc1)S(=O)(=O)c1ccccc1C | Homo sapiens | CHEMBL2390635 | single protein format |
| CHEMBL3667555 |  |
IC50 | = | 2.0 | nM | 410.95 | CSc1cccc(NC(=O)[C@@H]2CCCN2S(=O)(=O)c2cccc(Cl)c2)c1 | Homo sapiens | CHEMBL3707946 | assay format |
| CHEMBL3667559 |  |
IC50 | = | 2.0 | nM | 455.4 | CSc1cccc(NC(=O)[C@@H]2CCCN2S(=O)(=O)c2cccc(Br)c2)c1 | Homo sapiens | CHEMBL3707946 | assay format |
| CHEMBL3667562 |  |
IC50 | = | 2.0 | nM | 445.39 | CSc1cccc(NC(=O)[C@@H]2CCCN2S(=O)(=O)c2ccc(Cl)c(Cl)c2)c1 | Homo sapiens | CHEMBL3707946 | assay format |
| CHEMBL3981385 |  |
IC50 | = | 2.0 | nM | 427.51 | Cc1ccc(-n2nccn2)c(C(=O)N2CCCC[C@H]2Cc2cccc(-n3nccn3)c2)c1 | Homo sapiens | CHEMBL3887325 | assay format |
| CHEMBL3918712 |  |
IC50 | = | 3.0 | nM | 451.44 | O=C(c1cc(F)ccc1-n1nccn1)N1CCCOC1Cn1ccc(-c2ccc(F)cn2)n1 | Homo sapiens | CHEMBL3888032 | assay format |
| CHEMBL3983155 |  |
IC50 | = | 3.0 | nM | 433.45 | Cc1ccc(-n2nccn2)c(C(=O)N2CCOC2Cn2ccc(-c3ccc(F)cc3)n2)n1 | Homo sapiens | CHEMBL3888032 | assay format |
| CHEMBL3667558 |  |
IC50 | = | 3.0 | nM | 436.56 | COc1ccc(S(=O)(=O)N2CCC[C@H]2C(=O)Nc2cccc(SC)c2)cc1OC | Homo sapiens | CHEMBL3707946 | assay format |
| CHEMBL3667560 |  |
IC50 | = | 3.0 | nM | 424.98 | CSc1cccc(NC(=O)[C@@H]2CCCN2S(=O)(=O)c2ccc(C)c(Cl)c2)c1 | Homo sapiens | CHEMBL3707946 | assay format |
| CHEMBL3667554 |  |
IC50 | = | 3.0 | nM | 406.53 | COc1ccc(S(=O)(=O)N2CCC[C@H]2C(=O)Nc2cccc(SC)c2)cc1 | Homo sapiens | CHEMBL3707946 | assay format |
| CHEMBL3935533 |  |
IC50 | = | 3.2 | nM | 457.51 | Cc1ccc(-c2ncccn2)c(C(=O)N2CCCOC2Cn2cc(-c3ccc(F)cc3)cn2)c1 | Homo sapiens | CHEMBL3888032 | assay format |