O43613 | OX1R_HUMAN | Orexin/Hypocretin receptor type 1 (HCRTR1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 63~358 |
3D structures mapped by conservation among orthologs
[ Domain: "Family A G protein-coupled receptor-like" // 7tm_1_3 ]
[ Domain: "Family A G protein-coupled receptor-like" // 7tm_1_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3906374 |  |
IC50 | = | 0.1 | nM | 444.56 | Cc1ccc(-n2nccn2)c(C(=O)N2CCOC[C@H]2Cc2cccc(-c3cccs3)c2)c1 | Homo sapiens | CHEMBL3887324 | assay format |
| CHEMBL3941085 |  |
IC50 | = | 0.3 | nM | 445.55 | Cc1ccc(-n2nccn2)c(C(=O)N2CCOC[C@H]2Cc2cccc(-c3nccs3)c2)c1 | Homo sapiens | CHEMBL3887324 | assay format |
| CHEMBL3981385 |  |
IC50 | = | 0.3 | nM | 427.51 | Cc1ccc(-n2nccn2)c(C(=O)N2CCCC[C@H]2Cc2cccc(-n3nccn3)c2)c1 | Homo sapiens | CHEMBL3887324 | assay format |
| CHEMBL3946479 |  |
IC50 | = | 0.4 | nM | 458.52 | Cc1cc(C(=O)N2CCOC[C@H]2Cc2ccc(C)c(-c3ncon3)c2)c(-n2nccn2)cc1C | Homo sapiens | CHEMBL3887324 | assay format |
| CHEMBL3945012 |  |
IC50 | = | 0.5 | nM | 460.56 | COc1ccc(C[C@@H]2COCCN2C(=O)c2ccccc2-n2nccn2)cc1-c1cccs1 | Homo sapiens | CHEMBL3887324 | assay format |
| CHEMBL3917550 |  |
IC50 | = | 0.5 | nM | 413.49 | Cc1ccc(-n2nccn2)c(C(=O)N2CCC[C@H]2Cc2cccc(-n3nccn3)c2)c1 | Homo sapiens | CHEMBL3887324 | assay format |
| CHEMBL3934350 |  |
IC50 | = | 0.5 | nM | 430.53 | O=C(c1ccccc1-n1nccn1)N1CCOC[C@H]1Cc1cccc(-c2cccs2)c1 | Homo sapiens | CHEMBL3887324 | assay format |
| CHEMBL3893504 |  |
IC50 | = | 0.7 | nM | 461.5 | Cc1cc(C(=O)N2CCOC[C@H]2Cc2cc(-n3nccn3)ccc2F)c(-n2nccn2)cc1C | Homo sapiens | CHEMBL3887324 | assay format |
| CHEMBL3938842 |  |
IC50 | = | 0.7 | nM | 463.93 | Cc1cc(-n2nccn2)c(C(=O)N2CCOC[C@H]2Cc2cccc(-n3nccn3)c2)cc1Cl | Homo sapiens | CHEMBL3887324 | assay format |
| CHEMBL3985942 |  |
IC50 | = | 0.7 | nM | 447.47 | Cc1ccc(-n2nccn2)c(C(=O)N2CCCOC2Cn2ccc(-c3ccc(F)cn3)n2)c1 | Homo sapiens | CHEMBL3888031 | assay format |
| CHEMBL3959904 |  |
IC50 | = | 0.7 | nM | 460.49 | COc1ccc(C[C@@H]2COCCN2C(=O)c2cc(C)ccc2-n2nccn2)cc1-c1ncon1 | Homo sapiens | CHEMBL3887324 | assay format |
| CHEMBL3947761 |  |
IC50 | = | 0.7 | nM | 460.49 | COc1ccc(C[C@@H]2COCCN2C(=O)c2ccc(C)cc2-n2nccn2)cc1-c1ncon1 | Homo sapiens | CHEMBL3887324 | assay format |
| CHEMBL3946821 |  |
IC50 | = | 0.8 | nM | 446.49 | Cc1ccc(-n2nccn2)c(C(=O)N2CCCOC2Cn2cc(-c3ccc(F)cc3)cn2)c1 | Homo sapiens | CHEMBL3888031 | assay format |
| CHEMBL3983155 |  |
IC50 | = | 0.9 | nM | 433.45 | Cc1ccc(-n2nccn2)c(C(=O)N2CCOC2Cn2ccc(-c3ccc(F)cc3)n2)n1 | Homo sapiens | CHEMBL3888031 | assay format |
| CHEMBL3924228 |  |
IC50 | = | 0.9 | nM | 443.51 | Cc1ccc(C(=O)N2[C@H](Cc3cccc(-n4nccn4)c3)COC[C@H]2C)c(-n2nccn2)c1 | Homo sapiens | CHEMBL3887324 | assay format |
| CHEMBL3946019 |  |
IC50 | = | 1.0 | nM | 474.95 | C[C@@H]1CN(C(=O)c2ccc(Cl)cc2-n2nccn2)[C@H](Cc2cccc(-c3ncccn3)c2)CO1 | Homo sapiens | CHEMBL3887324 | assay format |
| CHEMBL3971859 |  |
IC50 | = | 1.0 | nM | 427.51 | Cc1ccc(-n2nccn2)c(C(=O)N2CCOC[C@H]2Cc2cccc(-n3cccc3)c2)c1 | Homo sapiens | CHEMBL3887324 | assay format |
| CHEMBL3894723 |  |
IC50 | = | 1.0 | nM | 454.53 | Cc1ccc(-n2nccn2)c(C(=O)N2C[C@@H](C)OC[C@H]2Cc2cccc(-c3ncccn3)c2)c1 | Homo sapiens | CHEMBL3887324 | assay format |
| CHEMBL3910117 |  |
IC50 | = | 1.0 | nM | 457.54 | Cc1cc(C(=O)N2C[C@@H](C)OC[C@H]2Cc2cccc(-n3nccn3)c2)c(-n2nccn2)cc1C | Homo sapiens | CHEMBL3887324 | assay format |
| CHEMBL3905303 |  |
IC50 | = | 1.0 | nM | 413.49 | O=C(c1ccccc1-n1nccn1)N1CCCC[C@H]1Cc1cccc(-n2nccn2)c1 | Homo sapiens | CHEMBL3887324 | assay format |