O43526 | KCNQ2_HUMAN | Potassium voltage-gated channel subfamily KQT member 2 (KCNQ2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00520 | Ion_trans - Ion transport protein | 96~322 | |
| PF03520 | KCNQ_channel - KCNQ voltage-gated potassium channel | 466~649 | |
| PF11956 | KCNQC3-Ank-G_bd - Ankyrin-G binding motif of KCNQ2-3 | 769~868 | |
| PF16642 | KCNQ2_u3 - Unstructured region on Potassium channel subunit alpha KvLQT2 | 665~755 |
3D structures mapped by conservation among orthologs
[ Domain: "Kv7 proximal C-terminal Domain" // KOG1419 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL343822 |  |
IC50 | = | 48.0 | nM | 412.44 | O=C1c2ccccc2C(Cc2ccnc(F)c2)(Cc2ccnc(F)c2)c2ccccc21 | Homo sapiens | CHEMBL4410389 | cell-based format |
| CHEMBL342375 |  |
IC50 | = | 55.0 | nM | 376.46 | O=C1c2ccccc2C(Cc2ccncc2)(Cc2ccncc2)c2ccccc21 | Homo sapiens | CHEMBL4410389 | cell-based format |
| CHEMBL4465132 |  |
IC50 | = | 160.0 | nM | 413.43 | O=C1c2ccccc2C(Cc2ccnnc2)(Cc2c(F)cncc2F)c2ccccc21 | Homo sapiens | CHEMBL4410389 | cell-based format |
| CHEMBL4471453 |  |
IC50 | = | 200.0 | nM | 448.42 | O=C1c2ccccc2C(Cc2c(F)cncc2F)(Cc2c(F)cncc2F)c2ccccc21 | Homo sapiens | CHEMBL4410389 | cell-based format |
| CHEMBL4447214 |  |
IC50 | = | 540.0 | nM | 404.51 | Cc1cc(CC2(Cc3ccnc(C)c3)c3ccccc3C(=O)c3ccccc32)ccn1 | Homo sapiens | CHEMBL4410389 | cell-based format |