O43497 | CAC1G_HUMAN | Voltage-dependent T-type calcium channel subunit alpha-1G (CACNA1G)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00520 | Ion_trans - Ion transport protein | 80~405 | |
| PF00520 | Ion_trans - Ion transport protein | 743~970 | |
| PF00520 | Ion_trans - Ion transport protein | 1275~1547 | |
| PF00520 | Ion_trans - Ion transport protein | 1611~1861 |
3D structures mapped by conservation among orthologs
[ Domain: "Voltage-gated ion channels" // Ion_trans ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4206509 |  |
IC50 | = | 1.0 | nM | 417.41 | O=C(Cc1ccc(C2CC(F)(F)C2)cc1)Nc1ccn(Cc2ccc(F)c(F)c2)n1 | Homo sapiens | CHEMBL4181719 | cell-based format |
| CHEMBL4204077 |  |
IC50 | = | 1.1 | nM | 368.87 | CN(C)c1ccc(CC(=O)Nc2ccn(Cc3ccc(Cl)cc3)n2)cc1 | Homo sapiens | CHEMBL4181719 | cell-based format |
| CHEMBL4214862 |  |
IC50 | = | 1.1 | nM | 433.41 | O=C(Cc1ccc(N2CCC(F)(F)C2)nc1)Nc1ccn(Cc2ccc(F)c(F)c2)n1 | Homo sapiens | CHEMBL4181719 | cell-based format |
| CHEMBL4207291 |  |
IC50 | = | 1.1 | nM | 443.43 | CCc1cc(CC(=O)Nc2ccn(Cc3ccc(C#N)cn3)n2)ccc1OCC(F)(F)F | Homo sapiens | CHEMBL4181719 | cell-based format |
| CHEMBL1684950 |  |
IC50 | = | 1.2 | nM | 380.41 | CC(C)c1ccc(CC(=O)N[C@H](C)c2ccc(OCC(F)(F)F)cn2)cc1 | Homo sapiens | CHEMBL3855331 | cell-based format |
| CHEMBL4203101 |  |
IC50 | = | 1.3 | nM | 424.45 | CN1C(=O)C(C)(C)c2cc(CC(=O)Nc3ccn(Cc4ccc(F)c(F)c4)n3)ccc21 | Homo sapiens | CHEMBL4181719 | cell-based format |
| CHEMBL4211105 |  |
IC50 | = | 1.4 | nM | 433.41 | O=C(Cc1ccc(OC2CC(F)(F)C2)cc1)Nc1ccn(Cc2ccc(F)c(F)c2)n1 | Homo sapiens | CHEMBL4181719 | cell-based format |
| CHEMBL4207031 |  |
IC50 | = | 1.4 | nM | 369.42 | CC(C)c1ccc(CC(=O)Nc2ccn(Cc3ccc(F)c(F)c3)n2)cc1 | Homo sapiens | CHEMBL4181719 | cell-based format |
| CHEMBL4205005 |  |
IC50 | = | 1.5 | nM | 370.4 | CN(C)c1ccc(CC(=O)Nc2ccn(Cc3ccc(F)c(F)c3)n2)cc1 | Homo sapiens | CHEMBL4181719 | cell-based format |
| CHEMBL4212039 |  |
IC50 | = | 1.9 | nM | 366.37 | O=C(Cc1ccc2cc[nH]c2c1)Nc1ccn(Cc2ccc(F)c(F)c2)n1 | Homo sapiens | CHEMBL4181719 | cell-based format |
| CHEMBL4208907 |  |
IC50 | = | 2.2 | nM | 429.4 | Cc1cc(CC(=O)Nc2ccn(Cc3ccc(C#N)cn3)n2)ccc1OCC(F)(F)F | Homo sapiens | CHEMBL4181719 | cell-based format |
| CHEMBL4204507 |  |
IC50 | = | 2.2 | nM | 418.42 | CN(C)c1ccc(CC(=O)Nc2ccn(Cc3ccc(OC(F)(F)F)cc3)n2)cc1 | Homo sapiens | CHEMBL4181719 | cell-based format |
| CHEMBL4205399 |  |
IC50 | = | 2.2 | nM | 377.44 | CC(C)c1ccc(CC(=O)Nc2ccn(CC3CCC(F)(F)CO3)n2)cc1 | Homo sapiens | CHEMBL4181719 | cell-based format |
| CHEMBL4207159 |  |
IC50 | = | 2.3 | nM | 366.37 | O=C(Cc1ccc2[nH]ccc2c1)Nc1ccn(Cc2ccc(F)c(F)c2)n1 | Homo sapiens | CHEMBL4181719 | cell-based format |
| CHEMBL4212176 |  |
IC50 | = | 2.3 | nM | 415.38 | Cc1cc(CC(=O)Nc2ccn(Cc3ccc(C#N)cn3)n2)ccc1OC(F)(F)F | Homo sapiens | CHEMBL4181719 | cell-based format |
| CHEMBL4215974 |  |
IC50 | = | 2.4 | nM | 397.43 | CC1(c2ccc(CC(=O)Nc3ccn(Cc4ccc(F)c(F)c4)n3)cc2)COC1 | Homo sapiens | CHEMBL4181719 | cell-based format |
| CHEMBL4209946 |  |
IC50 | = | 2.5 | nM | 415.42 | O=C(Cc1ccc(N2CC[C@H](F)C2)nc1)Nc1ccn(Cc2ccc(F)c(F)c2)n1 | Homo sapiens | CHEMBL4181719 | cell-based format |
| CHEMBL4204573 |  |
IC50 | = | 2.6 | nM | 443.43 | Cc1cc(CC(=O)Nc2ccn(Cc3ccc(C#N)cn3)n2)ccc1OCCC(F)(F)F | Homo sapiens | CHEMBL4181719 | cell-based format |
| CHEMBL4218608 |  |
IC50 | = | 2.8 | nM | 373.46 | CC(C)(C)c1ccc(CC(=O)Nc2ccn(Cc3ccc(C#N)cn3)n2)cc1 | Homo sapiens | CHEMBL4181719 | cell-based format |
| CHEMBL4218161 |  |
IC50 | = | 3.1 | nM | 377.42 | CN(C)c1ccc(CC(=O)Nc2ccn(Cc3ccc(C#N)c(F)c3)n2)cc1 | Homo sapiens | CHEMBL4181719 | cell-based format |