O43353 | RIPK2_HUMAN | Receptor-interacting serine/threonine-protein kinase 2 (RIPK2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00619 | CARD - Caspase recruitment domain | 437~519 | |
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 22~288 |
3D structures mapped by conservation among orthologs
[ Domain: "DEATH domain" // CARD ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4531690 |  |
IC50 | = | 0.011 | nM | 330.78 | Clc1cc2cc(c1)-c1cnn3ccc(nc13)NCCOCCO2 | Homo sapiens | CHEMBL4481511 | cell-based format |
| CHEMBL5187454 |  |
IC50 | = | 0.8 | nM | 351.41 | Nc1ncnc2c1c(-c1ccc3c(c1)OCO3)cn2[C@H]1CC[C@@H](N)CC1 | Homo sapiens | CHEMBL5136571 | single protein format |
| CHEMBL4293287 |  |
IC50 | = | 1.3 | nM | 388.49 | COc1cc2nccc(Nc3n[nH]c(C)c3C)c2cc1S(=O)(=O)C(C)(C)C | Homo sapiens | CHEMBL4269598 | assay format |
| CHEMBL5195615 |  |
IC50 | = | 1.6 | nM | 325.39 | Nc1ncnc2c1c(-c1ccc(F)cc1)cn2[C@H]1CC[C@@H](N)CC1 | Homo sapiens | CHEMBL5136571 | single protein format |
| CHEMBL4282034 |  |
IC50 | = | 1.6 | nM | 402.52 | CCOc1cc2nccc(Nc3n[nH]c(C)c3C)c2cc1S(=O)(=O)C(C)(C)C | Homo sapiens | CHEMBL4269598 | assay format |
| CHEMBL2105734 |  |
IC50 | = | 2.0 | nM | 443.3 | COCC[n+]1c2c(n(Cc3cnccn3)c1C)C(=O)c1ccccc1C2=O.[Br-] | Homo sapiens | CHEMBL5379430 | single protein format |
| CHEMBL4176853 |  |
IC50 | = | 2.0 | nM | 435.93 | COc1cc2ncc(-c3cc(Cl)cc(NC(C)=O)c3)n2cc1S(=O)(=O)C(C)(C)C | Homo sapiens | CHEMBL4135584 | single protein format |
| CHEMBL5171377 |  |
IC50 | = | 2.4 | nM | 321.43 | Cc1ccc(-c2cn([C@H]3CC[C@@H](N)CC3)c3ncnc(N)c23)cc1 | Homo sapiens | CHEMBL5136571 | single protein format |
| CHEMBL4292228 |  |
IC50 | = | 2.5 | nM | 432.55 | COCCOc1cc2nccc(Nc3n[nH]c(C)c3C)c2cc1S(=O)(=O)C(C)(C)C | Homo sapiens | CHEMBL4269598 | assay format |
| CHEMBL4289904 |  |
IC50 | = | 2.5 | nM | 418.52 | Cc1[nH]nc(Nc2ccnc3cc(OCCO)c(S(=O)(=O)C(C)(C)C)cc23)c1C | Homo sapiens | CHEMBL4269598 | assay format |
| CHEMBL4285837 |  |
IC50 | = | 2.5 | nM | 386.52 | CCc1cc2nccc(Nc3n[nH]c(C)c3C)c2cc1S(=O)(=O)C(C)(C)C | Homo sapiens | CHEMBL4269598 | assay format |
| CHEMBL5197634 |  |
IC50 | = | 3.0 | nM | 427.55 | COc1ccc(-c2cn([C@H]3CC[C@@H](NCc4ccccc4)CC3)c3ncnc(N)c23)cc1 | Homo sapiens | CHEMBL5136571 | single protein format |
| CHEMBL237347 |  |
IC50 | = | 3.0 | nM | 328.39 | Cc1ccc(O)cc1Nc1ccnc2ccc(S(C)(=O)=O)cc12 | Homo sapiens | CHEMBL3825637 | assay format |
| CHEMBL4171924 |  |
IC50 | = | 3.0 | nM | 392.46 | CCOc1cc2ncc(-c3cc(N)nc(F)c3)n2cc1S(=O)(=O)C(C)(C)C | Homo sapiens | CHEMBL4135584 | single protein format |
| CHEMBL4161327 |  |
IC50 | = | 3.0 | nM | 378.43 | CCOc1cc2ncc(-c3cc(N)nc(F)c3)n2cc1S(=O)(=O)C(C)C | Homo sapiens | CHEMBL4135584 | single protein format |
| CHEMBL939 |  |
IC50 | = | 3.8 | nM | 446.91 | COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1 | Homo sapiens | CHEMBL3888892 | cell-based format |
| CHEMBL5205764 |  |
IC50 | = | 3.9 | nM | 531.61 | COc1ccc(-c2cn([C@H]3CC[C@@H](NC(=O)c4cc(OC)c(OC)c(OC)c4)CC3)c3ncnc(N)c23)cc1 | Homo sapiens | CHEMBL5136571 | single protein format |
| CHEMBL4473105 |  |
IC50 | = | 4.0 | nM | 428.54 | COc1cc2ncnc(Nc3ccc4scnc4c3)c2cc1S(=O)(=O)C(C)(C)C | Homo sapiens | CHEMBL4367435 | single protein format |
| CHEMBL5205532 |  |
IC50 | = | 4.0 | nM | 340.41 | Nc1ccc(-c2cn([C@H]3CC[C@@H](N)CC3)c3ncnc(N)c23)cc1F | Homo sapiens | CHEMBL5136571 | single protein format |
| CHEMBL5174069 |  |
IC50 | = | 4.2 | nM | 337.43 | COc1ccc(-c2cn([C@H]3CC[C@@H](N)CC3)c3ncnc(N)c23)cc1 | Homo sapiens | CHEMBL5136571 | single protein format |