O43318 | M3K7_HUMAN | Mitogen-activated protein kinase kinase kinase 7 (MAP3K7)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 36~283 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3885421 |  |
IC50 | = | 1.7 | nM | 492.97 | C=CC(=O)Oc1ccccc1Nc1nc(Nc2cccc(N3CCN(C(C)=O)CC3)c2)ncc1Cl | Homo sapiens | CHEMBL3876688 | assay format |
| CHEMBL3823127 |  |
IC50 | = | 2.3 | nM | 473.56 | CN1CCN(C(=O)c2ccc(NC(=O)c3csc4c(=O)[nH]cnc34)c(-c3ccccc3)c2)CC1 | Homo sapiens | CHEMBL3826003 | cell-based format |
| CHEMBL3884839 |  |
IC50 | = | 2.4 | nM | 414.85 | C=CC(=O)Nc1ccccc1Oc1nc(Nc2cnn(CCOC)c2)ncc1Cl | Homo sapiens | CHEMBL3876688 | assay format |
| CHEMBL3823992 |  |
IC50 | = | 3.0 | nM | 459.5 | CC(F)Oc1cc(C(=O)N2CCN(C)CC2)ccc1NC(=O)c1csc2c(=O)[nH]cnc12 | Homo sapiens | CHEMBL3826003 | cell-based format |
| CHEMBL3884616 |  |
IC50 | = | 3.2 | nM | 451.91 | C=CC(=O)Oc1ccccc1Nc1nc(Nc2cccc(N3CCOCC3)c2)ncc1Cl | Homo sapiens | CHEMBL3876688 | assay format |
| CHEMBL3884569 |  |
IC50 | = | 3.3 | nM | 464.96 | C=CC(=O)Oc1ccccc1Nc1nc(Nc2ccc(N3CCN(C)CC3)cc2)ncc1Cl | Homo sapiens | CHEMBL3876688 | assay format |
| CHEMBL3823882 |  |
IC50 | = | 3.5 | nM | 439.54 | CC(C)c1cc(C(=O)N2CCN(C)CC2)ccc1NC(=O)c1csc2c(=O)[nH]cnc12 | Homo sapiens | CHEMBL3826003 | cell-based format |
| CHEMBL3884229 |  |
IC50 | = | 4.4 | nM | 451.91 | C=CC(=O)Oc1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2)ncc1Cl | Homo sapiens | CHEMBL3876688 | assay format |
| CHEMBL3884281 |  |
IC50 | = | 4.6 | nM | 440.89 | C=CC(=O)Nc1ccccc1Oc1nc(Nc2cnn(C3CCOCC3)c2)ncc1Cl | Homo sapiens | CHEMBL3876688 | assay format |
| CHEMBL3822845 |  |
IC50 | = | 5.0 | nM | 440.53 | CN1CCN(C(=O)c2ccc(NC(=O)c3csc4c(=O)[nH]cnc34)c(N(C)C)c2)CC1 | Homo sapiens | CHEMBL3826003 | cell-based format |
| CHEMBL3822712 |  |
IC50 | = | 5.2 | nM | 563.48 | CN1CCN(C(=O)c2ccc(NC(=O)c3csc4c(=O)[nH]cnc34)c(OC(C(F)(F)F)C(F)(F)F)c2)CC1 | Homo sapiens | CHEMBL3826003 | cell-based format |
| CHEMBL3823000 |  |
IC50 | = | 5.8 | nM | 431.91 | CN1CCN(C(=O)c2ccc(NC(=O)c3csc4c(=O)[nH]cnc34)c(Cl)c2)CC1 | Homo sapiens | CHEMBL3826003 | cell-based format |
| CHEMBL3822889 |  |
IC50 | = | 6.7 | nM | 479.61 | CN1CCN(C(=O)c2ccc(NC(=O)c3csc4c(=O)[nH]cnc34)c(C3CCCCC3)c2)CC1 | Homo sapiens | CHEMBL3826003 | cell-based format |
| CHEMBL3884642 |  |
IC50 | = | 7.0 | nM | 406.78 | C=CC(=O)Nc1ccccc1Oc1nc(Nc2cnn(C(F)F)c2)ncc1Cl | Homo sapiens | CHEMBL3876688 | assay format |
| CHEMBL3884143 |  |
IC50 | = | 7.3 | nM | 370.8 | C=CC(=O)Nc1ccccc1Oc1nc(Nc2cnn(C)c2)ncc1Cl | Homo sapiens | CHEMBL3876688 | assay format |
| CHEMBL3823892 |  |
IC50 | = | 7.3 | nM | 476.36 | CN1CCN(C(=O)c2ccc(NC(=O)c3csc4c(=O)[nH]cnc34)c(Br)c2)CC1 | Homo sapiens | CHEMBL3826003 | cell-based format |
| CHEMBL3823303 |  |
IC50 | = | 8.0 | nM | 477.54 | CCc1cc(Nc2ncc(F)c(-c3cnc4cccnn34)n2)cc(OCCN2CCC(O)CC2)c1 | Homo sapiens | CHEMBL3826557 | assay format |
| CHEMBL5076447 |  |
IC50 | = | 8.0 | nM | 432.53 | Cc1cnc(Nc2cccc(C(=O)N3CCCC3)c2)nc1N[C@H]1[C@@H](C(N)=O)[C@@H]2C=C[C@H]1C2 | Homo sapiens | CHEMBL5038455 | single protein format |
| CHEMBL3822535 |  |
IC50 | = | 9.3 | nM | 454.56 | CCN(C)c1cc(C(=O)N2CCN(C)CC2)ccc1NC(=O)c1csc2c(=O)[nH]cnc12 | Homo sapiens | CHEMBL3826003 | cell-based format |
| CHEMBL2407758 |  |
IC50 | = | 10.0 | nM | 458.55 | CC(=O)N1CCC(n2cc(-c3cnc(N)c4oc(-c5cccc6ncsc56)cc34)cn2)CC1 | Homo sapiens | CHEMBL2412855 | cell-based format |