O43293 | DAPK3_HUMAN | Death-associated protein kinase 3 (DAPK3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 13~275 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL388978 |  |
IC50 | = | 3.45 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328660 | single protein format |
| CHEMBL3103192 |  |
IC50 | = | 10.0 | nM | 419.49 | CC(=O)Nc1cc(Nc2cc(NC3CC3)n3ncc(C#N)c3n2)ccc1N(C)CCN | Homo sapiens | CHEMBL3810713 | single protein format |
| CHEMBL1230165 |  |
IC50 | = | 17.0 | nM | 349.78 | O=C(O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc12 | Homo sapiens | CHEMBL1663328 | single protein format |
| CHEMBL494089 |  |
IC50 | = | 81.0 | nM | 425.49 | CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)ncc(OC[C@H]3CCCNC3)c21 | Homo sapiens | CHEMBL1028113 | single protein format |
| CHEMBL3799389 |  |
IC50 | = | 140.0 | nM | 360.37 | O=C1Nc2ccc(NC(=O)C3CC3)cc2/C1=C1/Nc2ccccc2/C1=N\O | Homo sapiens | CHEMBL3802098 | single protein format |
| CHEMBL1091041 |  |
IC50 | = | 148.4 | nM | 329.15 | O=C1OC(c2cccc(Br)c2)=N/C1=C\c1cccnc1 | Homo sapiens | CHEMBL1112575 | single protein format |
| CHEMBL1091042 |  |
IC50 | = | 157.0 | nM | 359.18 | COc1ccc(C2=N/C(=C\c3cccnc3)C(=O)O2)c(Br)c1 | Homo sapiens | CHEMBL1112575 | single protein format |
| CHEMBL1091784 |  |
IC50 | = | 227.1 | nM | 410.6 | O=C1OC(c2cc(I)ccc2Cl)=N/C1=C\c1ccncc1 | Homo sapiens | CHEMBL1112575 | single protein format |
| CHEMBL4764610 |  |
IC50 | = | 260.0 | nM | 475.57 | COc1cc2c(=O)c3c4ccc(C#N)cc4[nH]c3n(C(C)C)c2c(F)c1N1C[C@@H](C)N(C)[C@@H](C)C1 | Homo sapiens | CHEMBL4705524 | single protein format |
| CHEMBL1091785 |  |
IC50 | = | 278.5 | nM | 329.7 | O=C1OC(c2ccc(Cl)c([N+](=O)[O-])c2)=N/C1=C\c1cccnc1 | Homo sapiens | CHEMBL1112575 | single protein format |
| CHEMBL1091766 |  |
IC50 | = | 278.5 | nM | 343.18 | Cc1cc(C2=N/C(=C\c3cccnc3)C(=O)O2)ccc1Br | Homo sapiens | CHEMBL1112575 | single protein format |
| CHEMBL1092139 |  |
IC50 | = | 291.2 | nM | 295.25 | O=C1OC(c2ccc([N+](=O)[O-])cc2)=N/C1=C\c1cccnc1 | Homo sapiens | CHEMBL1112575 | single protein format |
| CHEMBL5433785 |  |
IC50 | = | 310.0 | nM | 414.49 | COc1cnc(Nc2ccc(CS(C)(=O)=O)cc2)nc1Nc1cc(C2CC2)[nH]n1 | Homo sapiens | CHEMBL5318946 | single protein format |
| CHEMBL1091764 |  |
IC50 | = | 346.1 | nM | 286.24 | O=C1OC(c2ccc(F)c(F)c2)=N/C1=C\c1cccnc1 | Homo sapiens | CHEMBL1112575 | single protein format |
| CHEMBL1091765 |  |
IC50 | = | 359.6 | nM | 284.7 | O=C1OC(c2cccc(Cl)c2)=N/C1=C\c1cccnc1 | Homo sapiens | CHEMBL1112575 | single protein format |
| CHEMBL416056 |  |
IC50 | = | 360.0 | nM | 467.48 | COC(=O)[C@]1(O)C[C@@H]2O[C@@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL911981 | single protein format |
| CHEMBL1094004 |  |
IC50 | = | 395.3 | nM | 280.28 | COc1cccc(C2=N/C(=C\c3cccnc3)C(=O)O2)c1 | Homo sapiens | CHEMBL1112575 | single protein format |
| CHEMBL3797466 |  |
IC50 | = | 450.0 | nM | 374.4 | CC(C)=CC(=O)Nc1ccc2c(c1)/C(=C1/Nc3ccccc3/C1=N\O)C(=O)N2 | Homo sapiens | CHEMBL3802098 | single protein format |
| CHEMBL386636 |  |
IC50 | = | 487.0 | nM | 338.37 | O=C1NC(=O)c2c1c1c(c3[nH]c4ccccc4c23)CCc2ccccc2-1 | Homo sapiens | CHEMBL911981 | single protein format |
| CHEMBL3799585 |  |
IC50 | = | 510.0 | nM | 362.39 | CCCC(=O)Nc1ccc2c(c1)/C(=C1/Nc3ccccc3/C1=N\O)C(=O)N2 | Homo sapiens | CHEMBL3802098 | single protein format |