O15554 | KCNN4_HUMAN | Intermediate conductance calcium-activated potassium channel protein 4 (KCNN4)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF02888 | CaMBD - Calmodulin binding domain | 304~375 | |
| PF03530 | SK_channel - Calcium-activated SK potassium channel | 12~123 | |
| PF07885 | Ion_trans_2 - Ion channel | 212~289 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4744833 |  |
IC50 | = | 8.1 | nM | 374.38 | COC(=O)N(C[C@H]1CCCN1C)C1(c2ccc(F)c(C(F)(F)F)c2)CC1 | Homo sapiens | CHEMBL4672964 | cell-based format |
| CHEMBL4749039 |  |
IC50 | = | 8.6 | nM | 348.34 | COC(=O)N(CC(C)(C)N)C1(c2ccc(F)c(C(F)(F)F)c2)CC1 | Homo sapiens | CHEMBL4672964 | cell-based format |
| CHEMBL4791725 |  |
IC50 | = | 8.7 | nM | 376.35 | COC(=O)N(C[C@@H]1CCCN1)C1(c2ccc(F)c(OC(F)(F)F)c2)CC1 | Homo sapiens | CHEMBL4672964 | cell-based format |
| CHEMBL42205 |  |
IC50 | = | 9.0 | nM | 323.34 | NC(=O)C(c1ccccc1)(c1ccc(F)cc1)c1ccccc1F | Homo sapiens | CHEMBL948111 | single protein format |
| CHEMBL272039 |  |
IC50 | = | 10.0 | nM | 341.33 | NC(=O)C(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccccc1F | Homo sapiens | CHEMBL948111 | single protein format |
| CHEMBL405821 |  |
IC50 | = | 12.0 | nM | 323.34 | NC(=O)C(c1ccccc1)(c1ccc(F)cc1)c1ccc(F)cc1 | Homo sapiens | CHEMBL948111 | single protein format |
| CHEMBL260736 |  |
IC50 | = | 13.0 | nM | 341.33 | NC(=O)C(c1cccc(F)c1)(c1cccc(F)c1)c1cccc(F)c1 | Homo sapiens | CHEMBL948111 | single protein format |
| CHEMBL4788143 |  |
IC50 | = | 14.0 | nM | 344.4 | CC(C)(N)CN(CC1CC1)C1(c2ccc(F)c(C(F)(F)F)c2)CC1 | Homo sapiens | CHEMBL4672964 | cell-based format |
| CHEMBL272040 |  |
IC50 | = | 14.0 | nM | 323.34 | NC(=O)C(c1ccccc1)(c1ccccc1)c1ccc(F)c(F)c1 | Homo sapiens | CHEMBL948111 | single protein format |
| CHEMBL270704 |  |
IC50 | = | 14.0 | nM | 341.33 | NC(=O)C(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1 | Homo sapiens | CHEMBL948111 | single protein format |
| CHEMBL408700 |  |
IC50 | = | 15.0 | nM | 341.33 | NC(=O)C(c1ccc(F)cc1)(c1cccc(F)c1)c1cccc(F)c1 | Homo sapiens | CHEMBL948111 | single protein format |
| CHEMBL270071 |  |
IC50 | = | 15.0 | nM | 305.35 | NC(=O)C(c1ccccc1)(c1ccccc1)c1ccccc1F | Homo sapiens | CHEMBL948111 | single protein format |
| CHEMBL273092 |  |
IC50 | = | 15.0 | nM | 341.33 | NC(=O)C(c1ccc(F)cc1)(c1ccccc1F)c1ccccc1F | Homo sapiens | CHEMBL948111 | single protein format |
| CHEMBL260953 |  |
IC50 | = | 17.0 | nM | 341.33 | NC(=O)C(c1ccc(F)cc1)(c1ccc(F)cc1)c1cccc(F)c1 | Homo sapiens | CHEMBL948111 | single protein format |
| CHEMBL4756080 |  |
IC50 | = | 18.0 | nM | 326.41 | CC(C)(N)CN(C1CCC1)C1(c2cccc(C(F)(F)F)c2)CC1 | Homo sapiens | CHEMBL4672964 | cell-based format |
| CHEMBL498270 |  |
IC50 | = | 20.0 | nM | 344.85 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1cccn1 | Homo sapiens | CHEMBL1032478 | cell-based format |
| CHEMBL406683 |  |
IC50 | = | 20.0 | nM | 293.8 | NC(c1ccccc1)(c1ccccc1)c1ccccc1Cl | Homo sapiens | CHEMBL948111 | single protein format |
| CHEMBL4764429 |  |
IC50 | = | 24.0 | nM | 312.38 | CC(C)(N)CN(C1CC1)C1(c2cccc(C(F)(F)F)c2)CC1 | Homo sapiens | CHEMBL4672964 | cell-based format |
| CHEMBL261606 |  |
IC50 | = | 30.0 | nM | 323.34 | NC(=O)C(c1ccccc1)(c1ccccc1F)c1ccccc1F | Homo sapiens | CHEMBL948111 | single protein format |
| CHEMBL261828 |  |
IC50 | = | 30.0 | nM | 323.34 | NC(=O)C(c1ccccc1)(c1cccc(F)c1)c1cccc(F)c1 | Homo sapiens | CHEMBL948111 | single protein format |