O15550 | KDM6A_HUMAN | Lysine-specific demethylase 6A (KDM6A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF02373 | JmjC - JmjC domain, hydroxylase | 1133~1241 | |
| PF13181 | TPR_8 - Tetratricopeptide repeat | 205~233 | |
| PF21322 | KDM6_C-hel - Lysine-specific demethylase 6/UTY, C-terminal helical domain | 1248~1303 | |
| PF21326 | KDM6_GATAL - KDM6, GATA-like | 1320~1380 |
3D structures mapped by conservation among orthologs
[ Domain: "Double-stranded beta-helix" // JmjC_1 ]
[ Domain: "C-terminal helical domain in Jumonji domain-containing histone demethylases" // KOG1246_2nd ]
[ Domain: "LIM domain-like" // KOG1246_3rd ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3787193 |  |
IC50 | < | 100.0 | nM | 322.41 | CCN(CCN(C)C)C(=O)CNCc1cc(C(=O)OC)ccn1 | Homo sapiens | CHEMBL3789214 | assay format |
| CHEMBL3786593 |  |
IC50 | < | 100.0 | nM | 336.44 | CCOC(=O)c1ccnc(CNCC(=O)N(CC)CCN(C)C)c1 | Homo sapiens | CHEMBL3789214 | assay format |
| CHEMBL1230640 |  |
IC50 | = | 200.0 | nM | 189.17 | O=C(O)c1ccc(O)c2ncccc12 | Homo sapiens | CHEMBL5216099 | assay format |