O15496 | PA2GX_HUMAN | Group 10 secretory phospholipase A2 (PLA2G10)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00068 | Phospholip_A2_1 - Phospholipase A2 | 46~149 |
3D structures mapped by conservation among orthologs
[ Domain: "Phospholipase A2, PLA2" // Phospholip_A2_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL477548 |  |
IC50 | = | 7.0 | nM | 485.56 | CC(C)Cc1c(C(=O)C(N)=O)c2c(OCC(=O)NS(C)(=O)=O)cccc2n1Cc1ccccc1 | Homo sapiens | CHEMBL990836 | single protein format |
| CHEMBL514705 |  |
IC50 | = | 10.0 | nM | 458.51 | CC(C)Cc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cc3ccccc3c2n1Cc1ccccc1 | Homo sapiens | CHEMBL990836 | single protein format |
| CHEMBL514656 |  |
IC50 | = | 11.0 | nM | 561.66 | Cc1ccccc1S(=O)(=O)NC(=O)COc1cccc2c1c(C(=O)C(N)=O)c(CC(C)C)n2Cc1ccccc1 | Homo sapiens | CHEMBL990836 | single protein format |
| CHEMBL4215835 |  |
IC50 | = | 14.0 | nM | 407.35 | CC(CC(=O)O)c1cccc(-n2c(C(N)=O)cc3ccc(OC(F)(F)F)cc32)n1 | Homo sapiens | CHEMBL4199509 | single protein format |
| CHEMBL474874 |  |
IC50 | = | 14.0 | nM | 582.08 | CC(C)Cc1c(C(=O)C(N)=O)c2c(OCC(=O)NS(=O)(=O)c3ccccc3Cl)cccc2n1Cc1ccccc1 | Homo sapiens | CHEMBL990836 | single protein format |
| CHEMBL4210991 |  |
IC50 | = | 15.0 | nM | 406.36 | C[C@@H](CC(=O)O)c1cccc(-n2c(C(N)=O)cc3ccc(OC(F)(F)F)cc32)c1 | Homo sapiens | CHEMBL4199509 | single protein format |
| CHEMBL514692 |  |
IC50 | = | 15.0 | nM | 519.58 | CCc1c(C(=O)C(N)=O)c2c(OCC(=O)NS(=O)(=O)c3ccccc3)cccc2n1Cc1ccccc1 | Homo sapiens | CHEMBL990836 | single protein format |
| CHEMBL515637 |  |
IC50 | = | 20.0 | nM | 430.46 | CCc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cc3ccccc3c2n1Cc1ccccc1 | Homo sapiens | CHEMBL990836 | single protein format |
| CHEMBL148649 |  |
IC50 | = | 22.0 | nM | 394.43 | CCc1c(C(=O)C(N)=O)c2c(OC(C)C(=O)O)cccc2n1Cc1ccccc1 | Homo sapiens | CHEMBL990836 | single protein format |
| CHEMBL4171084 |  |
IC50 | = | 26.0 | nM | 392.33 | NC(=O)c1cc2ccc(OC(F)(F)F)cc2n1-c1cccc(CCC(=O)O)c1 | Homo sapiens | CHEMBL4151113 | assay format |
| CHEMBL4217510 |  |
IC50 | = | 29.0 | nM | 393.32 | NC(=O)c1cc2ccc(OC(F)(F)F)cc2n1-c1cccc(CCC(=O)O)n1 | Homo sapiens | CHEMBL4199509 | single protein format |
| CHEMBL506485 |  |
IC50 | = | 30.0 | nM | 597.69 | CC(C)Cc1c(C(=O)C(N)=O)c2c(OCC(=O)NS(=O)(=O)c3ccccc3)cc3ccccc3c2n1Cc1ccccc1 | Homo sapiens | CHEMBL990836 | single protein format |
| CHEMBL477549 |  |
IC50 | = | 30.0 | nM | 539.53 | CC(C)Cc1c(C(=O)C(N)=O)c2c(OCC(=O)NS(=O)(=O)C(F)(F)F)cccc2n1Cc1ccccc1 | Homo sapiens | CHEMBL990836 | single protein format |
| CHEMBL4214052 |  |
IC50 | = | 32.0 | nM | 406.36 | CC(Cc1cccc(-n2c(C(N)=O)cc3ccc(OC(F)(F)F)cc32)c1)C(=O)O | Homo sapiens | CHEMBL4199509 | single protein format |
| CHEMBL4204172 |  |
IC50 | = | 39.0 | nM | 422.36 | COC(Cc1cccc(-n2c(C(N)=O)cc3ccc(OC(F)(F)F)cc32)c1)C(=O)O | Homo sapiens | CHEMBL4199509 | single protein format |
| CHEMBL4176544 |  |
IC50 | = | 43.0 | nM | 376.33 | NC(=O)c1cc2ccc(C(F)(F)F)cc2n1-c1cccc(CCC(=O)O)c1 | Homo sapiens | CHEMBL4151113 | assay format |
| CHEMBL504813 |  |
IC50 | = | 50.0 | nM | 408.45 | CC(C)Cc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cccc2n1Cc1ccccc1 | Homo sapiens | CHEMBL990836 | single protein format |
| CHEMBL4205511 |  |
IC50 | = | 65.0 | nM | 407.35 | CC(Cc1cccc(-n2c(C(N)=O)cc3ccc(OC(F)(F)F)cc32)n1)C(=O)O | Homo sapiens | CHEMBL4199509 | single protein format |
| CHEMBL4160483 |  |
IC50 | = | 68.0 | nM | 374.34 | NC(=O)c1cc2ccc(OC(F)F)cc2n1-c1cccc(CCC(=O)O)c1 | Homo sapiens | CHEMBL4151113 | assay format |
| CHEMBL148674 |  |
IC50 | = | 75.0 | nM | 380.4 | CCc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cccc2n1Cc1ccccc1 | Homo sapiens | CHEMBL860950 | single protein format |