O15427 | MOT4_HUMAN | Monocarboxylate transporter 4 (SLC16A3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF07690 | MFS_1 - Major Facilitator Superfamily | 29~371 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5419465 |  |
IC50 | = | 0.23 | nM | 498.64 | Cc1nc2nc(C)c(C[C@@H]3CCN(c4ccc(-c5cnc(CN6CCOCC6)cn5)cc4)C3)c(C)n2n1 | Homo sapiens | CHEMBL5316574 | cell-based format |
| CHEMBL5399511 |  |
IC50 | = | 0.29 | nM | 498.64 | Cc1nc2nc(C)c(C[C@@H]3CCN(c4ccc(-c5ccc(CN6CCOCC6)nn5)cc4)C3)c(C)n2n1 | Homo sapiens | CHEMBL5316574 | cell-based format |
| CHEMBL5268154 |  |
IC50 | = | 0.3 | nM | 487.6 | CCn1ncc2ccc(-c3cc(CO[C@](C)(CC)C(=O)O)nn3-c3ccccc3N3CCCC3)cc21 | Homo sapiens | CHEMBL5234426 | cell-based format |
| CHEMBL5267318 |  |
IC50 | = | 0.36 | nM | 461.56 | CC[C@@](C)(OCc1cc(-c2cccc(OC3CC3)c2)n(-c2ccccc2N2CCC2)n1)C(=O)O | Homo sapiens | CHEMBL5234426 | cell-based format |
| CHEMBL5422048 |  |
IC50 | < | 0.38 | nM | 498.64 | Cc1nc2nc(C)c(C[C@@H]3CCN(c4cnc(-c5ccc(CN6CCOCC6)cc5)cn4)C3)c(C)n2n1 | Homo sapiens | CHEMBL5316574 | cell-based format |
| CHEMBL5270910 |  |
IC50 | = | 0.57 | nM | 487.6 | CCCn1ncc2ccc(-c3cc(CO[C@](C)(CC)C(=O)O)nn3-c3ccccc3N3CCC3)cc21 | Homo sapiens | CHEMBL5234426 | cell-based format |
| CHEMBL5425432 |  |
IC50 | = | 0.91 | nM | 511.68 | Cc1nc2nc(C)c(C[C@@H]3CCN(c4ccc(-c5ccc(CN6CCN(C)CC6)nn5)cc4)C3)c(C)n2n1 | Homo sapiens | CHEMBL5316574 | cell-based format |
| CHEMBL5219543 |  |
IC50 | = | 1.0 | nM | 350.42 | CC(C)(OCc1cc(-c2ccccc2)n(Cc2ccccc2)n1)C(=O)O | Homo sapiens | CHEMBL5216042 | cell-based format |
| CHEMBL4802043 |  |
IC50 | = | 1.0 | nM | 537.98 | CCOc1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C#Cc2cnc(C(=O)O)cc2OC)c2ncccc12 | Homo sapiens | CHEMBL4886127 | single protein format |
| CHEMBL1616099 |  |
IC50 | = | 1.0 | nM | 319.4 | Oc1cccc(C(O)CNCc2ccc(-c3ccccc3)cc2)c1 | Homo sapiens | CHEMBL5216042 | cell-based format |
| CHEMBL5434099 |  |
IC50 | = | 1.3 | nM | 500.61 | Cc1nc2nc(C)c(O[C@@H]3CCN(c4ccc(-c5ccc(CN6CCOCC6)nn5)cc4)C3)c(C)n2n1 | Homo sapiens | CHEMBL5316574 | cell-based format |
| CHEMBL5407216 |  |
IC50 | = | 1.7 | nM | 511.68 | Cc1nc2nc(C)c(C[C@@H]3CCN(c4cnc(-c5ccc(CN6CCN(C)CC6)cc5)cn4)C3)c(C)n2n1 | Homo sapiens | CHEMBL5316574 | cell-based format |
| CHEMBL375166 |  |
IC50 | = | 2.5 | nM | 461.54 | Cc1n[nH]c(C)c1Cc1sc2c(c1C(=O)N1C[C@H](O)CO1)c(=O)n(C)c(=O)n2CC(C)C | Homo sapiens | CHEMBL5242454 | cell-based format |
| CHEMBL5414818 |  |
IC50 | = | 2.5 | nM | 541.66 | CC(=O)N1CCN(Cc2ccc(-c3ccc(N4CC[C@@H](Oc5c(C)nc6nc(C)nn6c5C)C4)cc3)nn2)CC1 | Homo sapiens | CHEMBL5316574 | cell-based format |
| CHEMBL5416221 |  |
IC50 | = | 3.1 | nM | 513.65 | Cc1nc2nc(C)c(O[C@@H]3CCN(c4ccc(-c5ccc(CN6CCN(C)CC6)nn5)cc4)C3)c(C)n2n1 | Homo sapiens | CHEMBL5316574 | cell-based format |
| CHEMBL5417798 |  |
IC50 | = | 5.6 | nM | 393.48 | Cc1nc2nc(C)c(CCNC(=O)c3nnc(-c4ccccc4)s3)c(C)n2n1 | Homo sapiens | CHEMBL5316574 | cell-based format |
| CHEMBL5403188 |  |
IC50 | = | 6.3 | nM | 486.58 | Cc1nc2nc(C)c(CCNC(=O)c3cnc(-c4ccc([C@H]5COCCN5C)cc4)cn3)c(C)n2n1 | Homo sapiens | CHEMBL5316574 | cell-based format |
| CHEMBL5427454 |  |
IC50 | = | 6.8 | nM | 486.58 | Cc1nc2nc(C)c(CCNC(=O)c3cnc(-c4ccc(CN5CCOCC5)cc4)cn3)c(C)n2n1 | Homo sapiens | CHEMBL5316574 | cell-based format |
| CHEMBL3335793 |  |
IC50 | = | 7.1 | nM | 515.51 | Cc1[nH]nc(C(F)(F)F)c1Cc1sc2c(c1C(=O)N1C[C@](C)(O)CO1)c(=O)n(C)c(=O)n2C(C)C | Homo sapiens | CHEMBL5242454 | cell-based format |
| CHEMBL2442509 |  |
IC50 | = | 10.0 | nM | 309.32 | CN(Cc1ccccc1)c1ccc2cc(C(=O)O)c(=O)oc2c1 | Homo sapiens | CHEMBL2444903 | cell-based format |