O15393 | TMPS2_HUMAN | Transmembrane protease serine 2 (TMPRSS2)

Pfam Domain Table

AccessionDomainRangeColor
PF00089Trypsin - Trypsin256~484
PF15494SRCR_2 - Scavenger receptor cysteine-rich domain153~247

3D structures mapped by conservation among orthologs


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL3219087 Ki = 1.0 nM 593.75 COc1ccc(-c2cccc(S(=O)(=O)N[C@@H](Cc3cccc(C(=N)N)c3)C(=O)N3CCC(CCN)CC3)c2)c(OC)c1 Homo sapiens CHEMBL5216080 assay format
CHEMBL1229259 Ki = 20.0 nM 556.69 N=C(N)NCCC[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(C(=N)N)cc1 Homo sapiens CHEMBL1810435 assay format
CHEMBL1809250 Ki = 53.0 nM 501.66 CCC(NCc1ccc(C(=N)N)cc1)C(=O)[C@@H](CCCNC(=N)N)NS(=O)(=O)Cc1ccccc1 Homo sapiens CHEMBL1810435 assay format
CHEMBL1809251 Ki = 68.0 nM 515.68 CCC[C@H](NCc1ccc(C(=N)N)cc1)C(=O)[C@@H](CCCNC(=N)N)NS(=O)(=O)Cc1ccccc1 Homo sapiens CHEMBL1810435 assay format