O15357 | SHIP2_HUMAN | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (INPPL1)
Pfam Domain Table
Accession | Domain | Range | Color |
---|---|---|---|
PF00017 | SH2 - SH2 domain | 21~102 | |
PF00536 | SAM_1 - SAM domain (Sterile alpha motif) | 1202~1255 | |
PF22669 | Exo_endo_phos2 - Endonuclease/Exonuclease/phosphatase family 2 | 429~723 | |
PF24147 | C2_SHIP1-2_2nd - SHIP1/2 second C2 domain | 762~869 | |
PF24150 | C2_SHIP1-2_first - SHIP1/2 first C2 domain | 307~395 |
3D structures mapped by conservation among orthologs
[ Domain: "C2 domain" // ANAPC8 ]
[ Domain: "C2 domain" // UNK_F_TYPE ]
[ Domain: "SAM domain-like" // SAM_1 ]
[ Domain: "SH2" // SH2 ]
[ Domain: "DNase I-like" // Exo_endo_phos ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
---|---|---|---|---|---|---|---|---|---|---|
CHEMBL5081948 | IC50 | = | 61.0 | nM | 574.1 | O=P(O)(O)Oc1cc(F)c(-c2cc(OP(=O)(O)O)c(OP(=O)(O)O)cc2F)cc1OP(=O)(O)O | Homo sapiens | CHEMBL5053561 | single protein format | |
CHEMBL2337806 | IC50 | = | 620.0 | nM | 371.89 | C[C@H](NC(=O)c1sccc1OCc1ccc(Cl)cc1)c1ccccc1 | Homo sapiens | CHEMBL2343088 | single protein format | |
CHEMBL2337806 | Ki | = | 440.0 | nM | 371.89 | C[C@H](NC(=O)c1sccc1OCc1ccc(Cl)cc1)c1ccccc1 | Homo sapiens | CHEMBL5053566 | assay format | |
CHEMBL4282693 | Ki | = | 440.0 | nM | 428.29 | O=C(NCc1c(F)cccc1F)c1sccc1OCc1ccc(Cl)cc1Cl | Homo sapiens | CHEMBL5053566 | assay format |