O15357 | SHIP2_HUMAN | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (INPPL1)

Pfam Domain Table

AccessionDomainRangeColor
PF00017SH2 - SH2 domain21~102
PF00536SAM_1 - SAM domain (Sterile alpha motif)1202~1255
PF22669Exo_endo_phos2 - Endonuclease/Exonuclease/phosphatase family 2429~723
PF24147C2_SHIP1-2_2nd - SHIP1/2 second C2 domain762~869
PF24150C2_SHIP1-2_first - SHIP1/2 first C2 domain307~395

3D structures mapped by conservation among orthologs

[ Domain: "C2 domain" // ANAPC8 ]

 PyMOL session

[ Domain: "C2 domain" // UNK_F_TYPE ]

 PyMOL session

[ Domain: "SAM domain-like" // SAM_1 ]

 PyMOL session

[ Domain: "SH2" // SH2 ]

 PyMOL session

[ Domain: "DNase I-like" // Exo_endo_phos ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV    Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL5081948 IC50 = 61.0 nM 574.1 O=P(O)(O)Oc1cc(F)c(-c2cc(OP(=O)(O)O)c(OP(=O)(O)O)cc2F)cc1OP(=O)(O)O Homo sapiens CHEMBL5053561 single protein format
CHEMBL2337806 IC50 = 620.0 nM 371.89 C[C@H](NC(=O)c1sccc1OCc1ccc(Cl)cc1)c1ccccc1 Homo sapiens CHEMBL2343088 single protein format
CHEMBL2337806 Ki = 440.0 nM 371.89 C[C@H](NC(=O)c1sccc1OCc1ccc(Cl)cc1)c1ccccc1 Homo sapiens CHEMBL5053566 assay format
CHEMBL4282693 Ki = 440.0 nM 428.29 O=C(NCc1c(F)cccc1F)c1sccc1OCc1ccc(Cl)cc1Cl Homo sapiens CHEMBL5053566 assay format