O15296 | LX15B_HUMAN | Polyunsaturated fatty acid lipoxygenase ALOX15B (ALOX15B)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00305 | Lipoxygenase - Lipoxygenase | 211~656 | |
| PF01477 | PLAT - PLAT/LH2 domain | 5~118 |
3D structures mapped by conservation among orthologs
[ Domain: "Lipase/lipooxygenase domain (PLAT/LH2 domain)" // PLAT ]
[ Domain: "Lipoxygenase" // Lipoxygenase ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL235920 |  |
IC50 | = | 51.0 | nM | 597.78 | CCN([C@@H]1CCN(C(C)c2ccc(F)cc2)C1)S(=O)(=O)NCCc1nc(-c2cccs2)[nH]c1-c1ccc(OC)cc1 | Homo sapiens | CHEMBL897957 | cell-based format |
| CHEMBL399821 |  |
IC50 | = | 147.0 | nM | 509.7 | CCCCCc1ccc(S(=O)(=O)NCCc2nc(-c3cccs3)[nH]c2-c2ccc(OC)cc2)cc1 | Homo sapiens | CHEMBL897957 | cell-based format |
| CHEMBL1390514 |  |
IC50 | = | 340.0 | nM | 334.37 | FC(F)(F)c1ccc(CSc2nccn2-c2ccccc2)cc1 | Homo sapiens | CHEMBL4825389 | single protein format |
| CHEMBL392977 |  |
IC50 | = | 402.0 | nM | 503.67 | CCCCCc1ccc(S(=O)(=O)NCCc2nc(-c3ccccc3)[nH]c2-c2ccc(OC)cc2)cc1 | Homo sapiens | CHEMBL897957 | cell-based format |
| CHEMBL391659 |  |
IC50 | = | 433.0 | nM | 592.57 | COc1ccc(-c2[nH]c(-c3cccs3)nc2CCNS(=O)(=O)N2CCN(c3ccc(Cl)c(Cl)c3)CC2)cc1 | Homo sapiens | CHEMBL897957 | cell-based format |
| CHEMBL1520238 |  |
IC50 | = | 530.0 | nM | 345.27 | Brc1ccc(CSc2nccn2-c2ccccc2)cc1 | Homo sapiens | CHEMBL4825389 | single protein format |
| CHEMBL1352020 |  |
IC50 | = | 870.0 | nM | 294.42 | CCc1ccc(CSc2nccn2-c2ccccc2)cc1 | Homo sapiens | CHEMBL4825389 | single protein format |