O15264 | MK13_HUMAN | Mitogen-activated protein kinase 13 (MAPK13)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 28~308 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL2087507 |  |
IC50 | = | 0.64 | nM | 364.42 | Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccn2c(C3(C)CC3)nnc2c1 | Homo sapiens | CHEMBL2092446 | single protein format |
| CHEMBL2087515 |  |
IC50 | = | 0.83 | nM | 421.86 | Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccn2c(-c3ccncc3Cl)nnc2c1 | Homo sapiens | CHEMBL2092446 | single protein format |
| CHEMBL2087513 |  |
IC50 | = | 1.6 | nM | 420.88 | Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccn2c(-c3ccccc3Cl)nnc2c1 | Homo sapiens | CHEMBL2092446 | single protein format |
| CHEMBL2087524 |  |
IC50 | = | 1.7 | nM | 395.48 | Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccn2c(C(C)(C)N(C)C)nnc2c1 | Homo sapiens | CHEMBL2092446 | single protein format |
| CHEMBL2087509 |  |
IC50 | = | 1.9 | nM | 364.42 | Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccn2c(C3CCC3)nnc2c1 | Homo sapiens | CHEMBL2092446 | single protein format |
| CHEMBL2087501 |  |
IC50 | = | 2.0 | nM | 366.44 | Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccn2c(C(C)(C)C)nnc2c1 | Homo sapiens | CHEMBL2092446 | single protein format |
| CHEMBL2087503 |  |
IC50 | = | 3.0 | nM | 352.41 | Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccn2c(C(C)C)nnc2c1 | Homo sapiens | CHEMBL2092446 | single protein format |
| CHEMBL2087526 |  |
IC50 | = | 3.1 | nM | 368.41 | Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccn2c(C(C)(C)O)nnc2c1 | Homo sapiens | CHEMBL2092446 | single protein format |
| CHEMBL561932 |  |
IC50 | = | 4.0 | nM | 451.89 | Cn1c(=O)cc(Nc2cc(C(=O)NC3CC3)ccc2Cl)c2cnn(-c3ccc(F)cc3)c21 | Homo sapiens | CHEMBL1063393 | single protein format |
| CHEMBL2087742 |  |
IC50 | = | 6.2 | nM | 402.42 | Cc1c(F)cc(C(=O)NC2CC2)cc1-c1c(F)cn2c(C(C)(C)C)nnc2c1F | Homo sapiens | CHEMBL2092446 | single protein format |
| CHEMBL2087512 |  |
IC50 | = | 6.3 | nM | 402.89 | Cc1ccc(C(=O)NC2CC2)cc1-c1ccn2c(-c3ccccc3Cl)nnc2c1 | Homo sapiens | CHEMBL2092446 | single protein format |
| CHEMBL2087505 |  |
IC50 | = | 6.7 | nM | 350.4 | Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccn2c(C3CC3)nnc2c1 | Homo sapiens | CHEMBL2092446 | single protein format |
| CHEMBL2087743 |  |
IC50 | = | 6.7 | nM | 388.39 | Cc1c(F)cc(C(=O)NC2CC2)cc1-c1c(F)cn2c(C(C)C)nnc2c1F | Homo sapiens | CHEMBL2092446 | single protein format |
| CHEMBL2087522 |  |
IC50 | = | 9.4 | nM | 382.44 | COC(C)(C)c1nnc2cc(-c3cc(C(=O)NC4CC4)cc(F)c3C)ccn12 | Homo sapiens | CHEMBL2092446 | single protein format |
| CHEMBL2087744 |  |
IC50 | = | 10.0 | nM | 386.38 | Cc1c(F)cc(C(=O)NC2CC2)cc1-c1c(F)cn2c(C3CC3)nnc2c1F | Homo sapiens | CHEMBL2092446 | single protein format |
| CHEMBL2170294 |  |
IC50 | = | 11.0 | nM | 431.47 | Cc1ccccc1-n1nc(-c2c(-c3ccc(F)cc3)nn3c2NC[C@@H](CO)C3)ccc1=O | Homo sapiens | CHEMBL2172908 | single protein format |
| CHEMBL2087506 |  |
IC50 | = | 12.0 | nM | 346.43 | Cc1ccc(C(=O)NC2CC2)cc1-c1ccn2c(C3(C)CC3)nnc2c1 | Homo sapiens | CHEMBL2092446 | single protein format |
| CHEMBL2087746 |  |
IC50 | = | 12.0 | nM | 403.41 | Cc1c(F)cc(C(=O)NC2CC2)cc1-c1c(F)cn2c(C(C)(C)N)nnc2c1F | Homo sapiens | CHEMBL2092446 | single protein format |
| CHEMBL2087499 |  |
IC50 | = | 14.0 | nM | 375.47 | Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(N3CCCCC3)noc2c1 | Homo sapiens | CHEMBL2092446 | single protein format |
| CHEMBL2087747 |  |
IC50 | = | 15.0 | nM | 431.46 | Cc1c(F)cc(C(=O)NC2CC2)cc1-c1c(F)cn2c(C(C)(C)N(C)C)nnc2c1F | Homo sapiens | CHEMBL2092446 | single protein format |