O15146 | MUSK_HUMAN | Muscle, skeletal receptor tyrosine-protein kinase (MUSK)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01392 | Fz - Fz domain | 317~440 | |
| PF07679 | I-set - Immunoglobulin I-set domain | 28~110 | |
| PF07679 | I-set - Immunoglobulin I-set domain | 121~203 | |
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 576~856 | |
| PF13927 | Ig_3 - Immunoglobulin domain | 217~286 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL388978 |  |
IC50 | = | 3.8 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL3820662 | single protein format |
| CHEMBL4212531 |  |
IC50 | = | 53.0 | nM | 479.93 | CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(Cl)cn3)c2)c2cnc(N)nc21 | Homo sapiens | CHEMBL4681429 | single protein format |
| CHEMBL2151321 |  |
IC50 | < | 100.0 | nM | 381.42 | CC(C)Oc1cc(-n2cnc3ccc(N[C@@H](C)c4ccc(F)cn4)nc32)n[nH]1 | Homo sapiens | CHEMBL2155078 | single protein format |
| CHEMBL1774056 |  |
IC50 | = | 224.0 | nM | 355.35 | Cc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cn3)c(C#N)cc2F)n[nH]1 | Homo sapiens | CHEMBL1776851 | single protein format |
| CHEMBL5077961 |  |
IC50 | = | 306.0 | nM | 578.65 | Nc1nc(-c2cccc(-n3ccc4cc(C5CC5)cc(F)c4c3=O)c2CO)c2cc(C3=CCN(C4COC4)CC3)[nH]c2n1 | Homo sapiens | CHEMBL5054202 | assay format |
| CHEMBL3422092 |  |
IC50 | = | 690.0 | nM | 493.61 | O=C(N[C@@H](c1ccccn1)C1CC1)c1ccc2[nH]nc(-c3ccc(N4[C@H]5CC[C@H]4CC(O)C5)cc3)c2c1 | Homo sapiens | CHEMBL3423972 | single protein format |