O15111 | IKKA_HUMAN | Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 16~289 | |
| PF12179 | IKKbetaNEMObind - I-kappa-kinase-beta NEMO binding domain | 707~743 | |
| PF18397 | IKBKB_SDD - IQBAL scaffold dimerization domain | 386~659 |
3D structures mapped by conservation among orthologs
[ Domain: "Inhibitor of kappaB kinase beta dimerization domain" // KOG4250 ]
[ Domain: "Ubiquitin-like" // RAWUL_2 ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL549478 |  |
IC50 | = | 7.0 | nM | 295.32 | CNc1nc2[nH]c(-c3cccc(F)c3)cc2c2c1ncn2C | Homo sapiens | CHEMBL1025323 | single protein format |
| CHEMBL558491 |  |
IC50 | = | 7.0 | nM | 302.34 | CNc1nc2[nH]c(-c3cccc(C#N)c3)cc2c2c1ncn2C | Homo sapiens | CHEMBL1025323 | single protein format |
| CHEMBL551773 |  |
IC50 | = | 8.0 | nM | 307.36 | CNc1nc2[nH]c(-c3cccc(OC)c3)cc2c2c1ncn2C | Homo sapiens | CHEMBL1025323 | single protein format |
| CHEMBL4859206 |  |
IC50 | = | 10.58 | nM | 306.24 | Oc1ccccc1-c1nc(-c2ccc(C(F)(F)F)cc2)no1 | Homo sapiens | CHEMBL4837834 | single protein format |
| CHEMBL562720 |  |
IC50 | = | 11.0 | nM | 306.37 | CNc1nc2[nH]c(-c3cccc(CN)c3)cc2c2c1ncn2C | Homo sapiens | CHEMBL1025323 | single protein format |
| CHEMBL1876217 |  |
IC50 | = | 11.0 | nM | 238.25 | Oc1ccccc1-c1nc(-c2ccccc2)no1 | Homo sapiens | CHEMBL4837834 | single protein format |
| CHEMBL562971 |  |
IC50 | = | 12.0 | nM | 392.46 | CNc1nc2[nH]c(-c3cccc(CNC(=O)CCOC)c3)cc2c2c1ncn2C | Homo sapiens | CHEMBL1025323 | single protein format |
| CHEMBL552183 |  |
IC50 | = | 14.0 | nM | 348.41 | CNc1nc2[nH]c(-c3cccc(CNC(C)=O)c3)cc2c2c1ncn2C | Homo sapiens | CHEMBL1025323 | single protein format |
| CHEMBL4849098 |  |
IC50 | = | 15.94 | nM | 252.27 | Oc1ccccc1-c1nc(Cc2ccccc2)no1 | Homo sapiens | CHEMBL4837834 | single protein format |
| CHEMBL562370 |  |
IC50 | = | 22.0 | nM | 405.46 | CNc1nc2[nH]c(-c3cccc(CNC(=O)CCC(N)=O)c3)cc2c2c1ncn2C | Homo sapiens | CHEMBL1025323 | single protein format |
| CHEMBL360077 |  |
IC50 | = | 25.0 | nM | 294.36 | N#Cc1c(C2CCCNC2)cc(-c2ccccc2O)nc1N | Homo sapiens | CHEMBL828483 | single protein format |
| CHEMBL561447 |  |
IC50 | = | 25.0 | nM | 364.41 | CNc1nc2[nH]c(-c3cccc(CNC(=O)CO)c3)cc2c2c1ncn2C | Homo sapiens | CHEMBL1025323 | single protein format |
| CHEMBL382945 |  |
IC50 | = | 30.0 | nM | 546.79 | CCC(N)(CC)CCc1ccc(-c2ccnc(Nc3ccc(C(=O)N4CCC(N5CCCC5)CC4)cc3)n2)s1 | Homo sapiens | CHEMBL859877 | single protein format |
| CHEMBL199837 |  |
IC50 | = | 30.0 | nM | 518.73 | CC(C)(N)CCc1ccc(-c2ccnc(Nc3ccc(C(=O)N4CCC(N5CCCC5)CC4)cc3)n2)s1 | Homo sapiens | CHEMBL859877 | single protein format |
| CHEMBL551024 |  |
IC50 | = | 32.0 | nM | 519.5 | NCc1ccc(-c2cnc3[nH]cc(-c4cccc(NC(=O)Nc5ccc(C(F)(F)F)cc5F)c4)c3c2)cc1 | Homo sapiens | CHEMBL1026937 | single protein format |
| CHEMBL590109 |  |
IC50 | = | 33.0 | nM | 425.52 | NCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 | Homo sapiens | CHEMBL1072654 | single protein format |
| CHEMBL560708 |  |
IC50 | = | 39.0 | nM | 418.49 | CNc1nc2[nH]c(-c3cccc(CNC(=O)c4csnn4)c3)cc2c2c1ncn2C | Homo sapiens | CHEMBL1025323 | single protein format |
| CHEMBL565076 |  |
IC50 | = | 40.0 | nM | 277.33 | CNc1nc2[nH]c(-c3ccccc3)cc2c2c1ncn2C | Homo sapiens | CHEMBL1025323 | single protein format |
| CHEMBL549479 |  |
IC50 | = | 43.0 | nM | 295.32 | CNc1nc2[nH]c(-c3ccc(F)cc3)cc2c2c1ncn2C | Homo sapiens | CHEMBL1025323 | single protein format |
| CHEMBL556806 |  |
IC50 | = | 44.0 | nM | 295.32 | CNc1nc2[nH]c(-c3ccccc3F)cc2c2c1ncn2C | Homo sapiens | CHEMBL1025323 | single protein format |