O15075 | DCLK1_HUMAN | Serine/threonine-protein kinase DCLK1 (DCLK1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 390~647 | |
| PF03607 | DCX - Doublecortin | 76~137 | |
| PF03607 | DCX - Doublecortin | 204~263 |
3D structures mapped by conservation among orthologs
[ Domain: "Ubiquitin-like" // DCX ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1673048 |  |
IC50 | = | 1.0 | nM | 501.59 | COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2C | Homo sapiens | CHEMBL4612962 | assay format |
| CHEMBL4643632 |  |
IC50 | = | 2.0 | nM | 515.62 | CCN1C(=O)c2ccccc2N(C)c2nc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3OC)ncc21 | Homo sapiens | CHEMBL4612962 | assay format |
| CHEMBL4646447 |  |
IC50 | = | 2.0 | nM | 424.49 | CN1C(=O)c2ccccc2N(C)c2nc(Nc3ccc(NS(C)(=O)=O)cc3)ncc21 | Homo sapiens | CHEMBL4612962 | assay format |
| CHEMBL4634326 |  |
IC50 | = | 3.0 | nM | 473.58 | CCN1C(=O)c2ccccc2N(C)c2nc(Nc3ccc(N4CCN(C)CC4)cc3OC)ncc21 | Homo sapiens | CHEMBL4612962 | assay format |
| CHEMBL4636475 |  |
IC50 | = | 3.0 | nM | 454.51 | COc1cc(NS(C)(=O)=O)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2C | Homo sapiens | CHEMBL4612962 | assay format |
| CHEMBL4645267 |  |
IC50 | = | 4.0 | nM | 535.65 | COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(n1)N(Cc1ccccc1)c1ccccc1C(=O)N2C | Homo sapiens | CHEMBL4612962 | assay format |
| CHEMBL4640016 |  |
IC50 | = | 10.0 | nM | 569.59 | COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2CC(F)(F)F | Homo sapiens | CHEMBL4612962 | assay format |
| CHEMBL1673041 |  |
IC50 | = | 11.0 | nM | 446.51 | COc1cc(N2CCOCC2)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2C | Homo sapiens | CHEMBL4612962 | assay format |
| CHEMBL1673039 |  |
IC50 | = | 11.0 | nM | 459.55 | COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2C | Homo sapiens | CHEMBL4612962 | assay format |
| CHEMBL4636072 |  |
IC50 | = | 14.0 | nM | 499.62 | COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(n1)N(C1CCC1)c1ccccc1C(=O)N2C | Homo sapiens | CHEMBL4612962 | assay format |
| CHEMBL4639395 |  |
IC50 | = | 17.0 | nM | 527.55 | COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2CC(F)(F)F | Homo sapiens | CHEMBL4612962 | assay format |
| CHEMBL1673053 |  |
IC50 | = | 26.0 | nM | 513.65 | COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(n1)N(C1CCCC1)c1ccccc1C(=O)N2C | Homo sapiens | CHEMBL4612962 | assay format |
| CHEMBL4554938 |  |
IC50 | = | 27.9 | nM | 416.49 | CN1C(=O)c2sccc2N(C)c2nc(Nc3ccc(S(N)(=O)=O)cc3)ncc21 | Homo sapiens | CHEMBL5212969 | single protein format |
| CHEMBL4648947 |  |
IC50 | = | 32.0 | nM | 501.64 | CCC(C)N1c2ccccc2C(=O)N(C)c2cnc(Nc3ccc(N4CCN(C)CC4)cc3OC)nc21 | Homo sapiens | CHEMBL4612962 | assay format |
| CHEMBL4644273 |  |
IC50 | = | 36.0 | nM | 468.54 | CCN1C(=O)c2ccccc2N(C)c2nc(Nc3ccc(NS(C)(=O)=O)cc3OC)ncc21 | Homo sapiens | CHEMBL4612962 | assay format |
| CHEMBL4634025 |  |
IC50 | = | 37.0 | nM | 444.54 | Cc1cc(N2CCC(O)CC2)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2C | Homo sapiens | CHEMBL4612962 | assay format |
| CHEMBL1673042 |  |
IC50 | = | 52.0 | nM | 445.53 | COc1cc(N2CCNCC2)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2C | Homo sapiens | CHEMBL4612962 | assay format |
| CHEMBL4647792 |  |
IC50 | = | 58.0 | nM | 570.7 | COc1cc(C(=O)N2CCN(C3CCN(C)CC3)CC2)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2C | Homo sapiens | CHEMBL4612962 | assay format |
| CHEMBL1673052 |  |
IC50 | = | 71.0 | nM | 487.61 | COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(n1)N(C(C)C)c1ccccc1C(=O)N2C | Homo sapiens | CHEMBL4612962 | assay format |
| CHEMBL4641263 |  |
IC50 | = | 80.0 | nM | 522.51 | COc1cc(NS(C)(=O)=O)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2CC(F)(F)F | Homo sapiens | CHEMBL4612962 | assay format |