O14980 | XPO1_HUMAN | Exportin-1 (XPO1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF03810 | IBN_N - Importin-beta N-terminal domain | 46~111 | |
| PF08389 | Xpo1 - Exportin 1-like protein | 124~268 | |
| PF08767 | CRM1_C - CRM1 C terminal | 709~1026 | |
| PF18777 | CRM1_repeat - Chromosome region maintenance or exportin repeat | 345~381 | |
| PF18784 | CRM1_repeat_2 - CRM1 / Exportin repeat 2 | 405~472 | |
| PF18787 | CRM1_repeat_3 - CRM1 / Exportin repeat 3 | 485~535 |
3D structures mapped by conservation among orthologs
[ Domain: "ARM repeat" // CRM1_C ]
[ Domain: "ARM repeat" // Xpo1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL486133 |  |
IC50 | = | 1.0 | nM | 540.74 | CCC(=C/[C@H](C)C/C=C/C(C)=C/[C@@H](C)C(=O)[C@@H](C)[C@H](O)[C@@H](C)C/C(C)=C/C(=O)O)/C=C/[C@@H]1OC(=O)C=C[C@@H]1C | Homo sapiens | CHEMBL4024845 | cell-based format |
| CHEMBL4088268 |  |
IC50 | = | 10.0 | nM | 496.73 | C/C=C(\C)C[C@H](C)[C@@H](O)[C@H](C)C(=O)[C@H](C)/C=C(C)/C=C/C[C@@H](C)/C=C(\C=C\[C@H]1CC=CC(=O)O1)CC | Homo sapiens | CHEMBL4024845 | cell-based format |
| CHEMBL4077955 |  |
IC50 | = | 25.0 | nM | 234.34 | CCC(=C/C(C)C)/C=C/[C@@H]1OC(=O)C=C[C@@H]1C | Homo sapiens | CHEMBL4024845 | cell-based format |
| CHEMBL3545185 |  |
IC50 | = | 34.0 | nM | 443.31 | O=C(/C=C\n1cnc(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1)NNc1cnccn1 | Homo sapiens | CHEMBL5332019 | cell-based format |
| CHEMBL3898452 |  |
IC50 | = | 112.0 | nM | 355.32 | COc1cc(-c2ncn(/C=C\C(=O)OC(C)C)n2)cc(C(F)(F)F)c1 | Homo sapiens | CHEMBL5332019 | cell-based format |
| CHEMBL4440028 |  |
IC50 | = | 151.0 | nM | 373.34 | [O-][S@@+](/C=C/CCN=C=S)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | Homo sapiens | CHEMBL4405709 | cell-based format |
| CHEMBL5401589 |  |
IC50 | = | 280.0 | nM | 504.71 | C/C=C/[C@@H]1O[C@H]([C@H](N)/C=C/C=C(\C)C[C@@H](C)/C=C(C)\C=C\[C@H](O)C[C@H](N)CC(=O)OC)C[C@H](O)[C@@H]1C | Homo sapiens | CHEMBL5324132 | cell-based format |
| CHEMBL5437643 |  |
IC50 | = | 340.0 | nM | 504.71 | C/C=C/[C@@H]1O[C@H]([C@@H](N)/C=C/C=C(\C)C[C@@H](C)/C=C(C)\C=C\[C@H](O)C[C@H](N)CC(=O)OC)C[C@H](O)[C@@H]1C | Homo sapiens | CHEMBL5324132 | cell-based format |
| CHEMBL3908937 |  |
IC50 | <= | 1000.0 | nM | 333.78 | O=C(/C=C\n1cnc(-c2cccc(Cl)c2)n1)OC1CCOCC1 | Homo sapiens | CHEMBL3880038 | cell-based format |
| CHEMBL3931058 |  |
IC50 | <= | 1000.0 | nM | 350.81 | CC(C)OC(=O)/C=C\n1cnc(-c2cc(Cl)nc(OC(C)C)c2)n1 | Homo sapiens | CHEMBL3880038 | cell-based format |
| CHEMBL3929869 |  |
IC50 | = | 1000.0 | nM | 333.73 | O=C(/C=C\n1cnc(-c2cccc(Cl)c2)n1)OC1COC(=O)C1 | Homo sapiens | CHEMBL3880038 | cell-based format |
| CHEMBL3938232 |  |
IC50 | <= | 1000.0 | nM | 288.74 | O=C(/C=C\n1cnc(-c2cccc(Cl)c2)n1)N1CCC1 | Homo sapiens | CHEMBL3880038 | cell-based format |
| CHEMBL3916670 |  |
IC50 | <= | 1000.0 | nM | 292.73 | CC(C)OC(=O)/C=C\n1cnc(-c2cncc(Cl)c2)n1 | Homo sapiens | CHEMBL3880038 | cell-based format |
| CHEMBL3926680 |  |
IC50 | <= | 1000.0 | nM | 307.74 | CCOC(=O)/C=C\n1cnc(-c2cc(Cl)cc(OC)c2)n1 | Homo sapiens | CHEMBL3880038 | cell-based format |
| CHEMBL3910886 |  |
IC50 | <= | 1000.0 | nM | 283.74 | CS(=O)(=O)/C=C\n1cnc(-c2cccc(Cl)c2)n1 | Homo sapiens | CHEMBL3880038 | cell-based format |
| CHEMBL3913559 |  |
IC50 | <= | 1000.0 | nM | 230.66 | N#C/C=C\n1cnc(-c2cccc(Cl)c2)n1 | Homo sapiens | CHEMBL3880038 | cell-based format |
| CHEMBL3948709 |  |
IC50 | <= | 1000.0 | nM | 327.17 | CC(C)OC(=O)/C=C\n1cnc(-c2cc(Cl)nc(Cl)c2)n1 | Homo sapiens | CHEMBL3880038 | cell-based format |
| CHEMBL3983477 |  |
IC50 | <= | 1000.0 | nM | 297.77 | CC(C)OC(=O)/C=C\n1cnc(-c2csc(Cl)c2)n1 | Homo sapiens | CHEMBL3880038 | cell-based format |
| CHEMBL3970691 |  |
IC50 | <= | 1000.0 | nM | 271.32 | Cc1cccc(-c2ncn(/C=C\C(=O)OC(C)C)n2)c1 | Homo sapiens | CHEMBL3880038 | cell-based format |
| CHEMBL3959872 |  |
IC50 | <= | 1000.0 | nM | 375.73 | CC(C)OC(=O)/C=C\n1cnc(-c2cc(Cl)cc(OC(F)(F)F)c2)n1 | Homo sapiens | CHEMBL3880038 | cell-based format |