O14976 | GAK_HUMAN | Cyclin-G-associated kinase (GAK)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 43~312 | |
| PF10409 | PTEN_C2 - C2 domain of PTEN tumour-suppressor protein | 570~708 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4531690 |  |
IC50 | = | 0.06 | nM | 330.78 | Clc1cc2cc(c1)-c1cnn3ccc(nc13)NCCOCCO2 | Homo sapiens | CHEMBL4481510 | cell-based format |
| CHEMBL1287853 |  |
IC50 | = | 1.0 | nM | 524.69 | Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1 | Homo sapiens | CHEMBL5131610 | single protein format |
| CHEMBL4740761 |  |
IC50 | = | 2.2 | nM | 445.55 | COc1cc(-c2cnc3c(-c4cccc(NC(=O)N5CCCC5)c4)snc3c2)ccc1N | Homo sapiens | CHEMBL4736826 | single protein format |
| CHEMBL81073 |  |
IC50 | = | 2.4 | nM | 395.42 | COc1cc2ncc(C#N)c(Nc3cc(OC)c(OC)c(OC)c3)c2cc1OC | Homo sapiens | CHEMBL4394509 | cell-based format |
| CHEMBL4778276 |  |
IC50 | = | 3.2 | nM | 461.55 | COc1cc(-c2cnc3c(-c4cccc(NC(=O)N5CCOCC5)c4)snc3c2)ccc1N | Homo sapiens | CHEMBL4736826 | single protein format |
| CHEMBL4762694 |  |
IC50 | = | 3.8 | nM | 418.52 | COc1cc(-c2cnc3c(-c4cccc(NC(=O)C(C)C)c4)snc3c2)ccc1N | Homo sapiens | CHEMBL4736826 | single protein format |
| CHEMBL4764705 |  |
IC50 | = | 7.7 | nM | 404.5 | CCC(=O)Nc1cccc(-c2snc3cc(-c4ccc(N)c(OC)c4)cnc23)c1 | Homo sapiens | CHEMBL4736826 | single protein format |
| CHEMBL4794323 |  |
IC50 | = | 8.8 | nM | 416.51 | COc1cc(-c2cnc3c(-c4cccc(NC(=O)C5CC5)c4)snc3c2)ccc1N | Homo sapiens | CHEMBL4736826 | single protein format |
| CHEMBL1738797 |  |
IC50 | < | 10.0 | nM | 482.63 | CCc1cc2c(cc1N1CCC(N3CCOCC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O | Homo sapiens | CHEMBL4705535 | single protein format |
| CHEMBL388978 |  |
IC50 | = | 11.0 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4736826 | single protein format |
| CHEMBL4745919 |  |
IC50 | = | 12.0 | nM | 402.48 | C=CC(=O)Nc1cccc(-c2snc3cc(-c4ccc(N)c(OC)c4)cnc23)c1 | Homo sapiens | CHEMBL4736826 | single protein format |
| CHEMBL4745028 |  |
IC50 | = | 13.0 | nM | 437.57 | COc1cc(-c2cnc3c(N4CCC[C@H](CNC(=O)C5CC5)C4)snc3c2)ccc1N | Homo sapiens | CHEMBL4736826 | single protein format |
| CHEMBL4800032 |  |
IC50 | = | 14.0 | nM | 437.57 | COc1cc(-c2cnc3c(N4CCCC(CNC(=O)C5CC5)C4)snc3c2)ccc1N | Homo sapiens | CHEMBL4736826 | single protein format |
| CHEMBL4779229 |  |
IC50 | = | 17.0 | nM | 444.56 | COc1cc(-c2cnc3c(-c4cccc(NC(=O)C5CCCC5)c4)snc3c2)ccc1N | Homo sapiens | CHEMBL4736826 | single protein format |
| CHEMBL4646895 |  |
IC50 | = | 22.0 | nM | 398.49 | COc1cc(-c2cnc3c(N4C[C@@H](C)O[C@@H](C)C4)snc3c2)ccc1C(N)=O | Homo sapiens | CHEMBL4610426 | cell-based format |
| CHEMBL311959 |  |
IC50 | = | 23.0 | nM | 370.41 | COc1cc2nccc(Nc3cc(OC)c(OC)c(OC)c3)c2cc1OC | Homo sapiens | CHEMBL4394509 | cell-based format |
| CHEMBL4642467 |  |
IC50 | = | 24.0 | nM | 385.49 | COc1ccc(-c2ccc3nsc(N4C[C@@H](C)O[C@@H](C)C4)c3n2)cc1OC | Homo sapiens | CHEMBL4610426 | cell-based format |
| CHEMBL4440586 |  |
IC50 | = | 31.0 | nM | 329.36 | C#Cc1cccc(Nc2c(C#N)cnc3cc(OC)c(OC)cc23)c1 | Homo sapiens | CHEMBL4394509 | cell-based format |
| CHEMBL4752286 |  |
IC50 | = | 35.0 | nM | 473.6 | COc1cc(-c2cnc3c(N4CCCC(CNC(=O)c5ccccc5)C4)snc3c2)ccc1N | Homo sapiens | CHEMBL4736826 | single protein format |
| CHEMBL4784439 |  |
IC50 | = | 37.0 | nM | 466.61 | COc1cc(-c2cnc3c(N4CCCC(CNC(=O)N5CCCC5)C4)snc3c2)ccc1N | Homo sapiens | CHEMBL4736826 | single protein format |