O14939 | PLD2_HUMAN | Phospholipase D2 (PLD2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00614 | PLDc - Phospholipase D Active site motif | 438~464 | |
| PF00787 | PX - PX domain | 92~191 | |
| PF13091 | PLDc_2 - PLD-like domain | 627~795 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4475943 |  |
IC50 | = | 2.5 | nM | 434.52 | O=C(NCCN1CCC2(CC1)C(=O)NC[C@H]2c1ccc(F)cc1)c1cc2ccccc2[nH]1 | Homo sapiens | CHEMBL4329650 | cell-based format |
| CHEMBL4453586 |  |
IC50 | = | 12.0 | nM | 448.54 | C[C@@H](CN1CCC2(CC1)C(=O)NC[C@H]2c1ccc(F)cc1)NC(=O)c1cc2ccccc2[nH]1 | Homo sapiens | CHEMBL4329650 | cell-based format |
| CHEMBL492972 |  |
IC50 | = | 14.0 | nM | 418.42 | O=C(NCCN1CCC(n2c(=O)[nH]c3ccc(F)cc32)CC1)c1ccc(F)c(F)c1 | Homo sapiens | CHEMBL957605 | cell-based format |
| CHEMBL398567 |  |
IC50 | = | 20.0 | nM | 421.48 | O=C(NCCN1CCC(n2c(=O)[nH]c3ccccc32)CC1)c1cc2cc(F)ccc2[nH]1 | Homo sapiens | CHEMBL886696 | single protein format |
| CHEMBL246240 |  |
IC50 | = | 20.0 | nM | 403.49 | O=C(NCCN1CCC(n2c(=O)[nH]c3ccccc32)CC1)c1cc2ccccc2[nH]1 | Homo sapiens | CHEMBL886696 | single protein format |
| CHEMBL4446255 |  |
IC50 | = | 20.0 | nM | 489.39 | C[C@@H](CN1CCC2(CC1)C(=O)NCN2c1cccc(F)c1)NC(=O)c1ccc(Br)cc1 | Homo sapiens | CHEMBL4329646 | single protein format |
| CHEMBL3925090 |  |
IC50 | = | 20.0 | nM | 446.53 | O=C(NCCN1CCC2(CC1)CNC(=O)N2c1cccc(F)c1)c1ccc2ccccc2c1 | Homo sapiens | CHEMBL3889075 | cell-based format |
| CHEMBL1254577 |  |
IC50 | = | 20.0 | nM | 446.53 | O=C(NCCN1CCC2(CC1)C(=O)NCN2c1cccc(F)c1)c1ccc2ccccc2c1 | Homo sapiens | CHEMBL1250951 | cell-based format |
| CHEMBL1254736 |  |
IC50 | = | 25.0 | nM | 453.49 | O=C(NCCN1CCC2(CC1)C(=O)NCN2c1cccc(F)c1)c1cc2cc(F)ccc2[nH]1 | Homo sapiens | CHEMBL1250951 | cell-based format |
| CHEMBL4594070 |  |
IC50 | = | 26.0 | nM | 459.57 | C[C@@H](CN1CCC2(CC1)C(=O)NC[C@H]2c1ccc(F)cc1)NC(=O)c1ccc2ccccc2c1 | Homo sapiens | CHEMBL4329650 | cell-based format |
| CHEMBL1253900 |  |
IC50 | = | 30.0 | nM | 453.49 | O=C(NCCN1CCC2(CC1)C(=O)NCN2c1ccc(F)cc1)c1cc2cc(F)ccc2[nH]1 | Homo sapiens | CHEMBL1250951 | cell-based format |
| CHEMBL471257 |  |
IC50 | = | 30.0 | nM | 434.57 | O=C(NCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1cc2ccccc2s1 | Homo sapiens | CHEMBL998624 | cell-based format |
| CHEMBL2325482 |  |
IC50 | = | 35.0 | nM | 428.48 | C[C@@H](CN1CCC2(CC1)C(=O)NCN2c1cccc(F)c1)NC(=O)c1ccc(F)cc1 | Homo sapiens | CHEMBL2330327 | cell-based format |
| CHEMBL1253820 |  |
IC50 | = | 40.0 | nM | 447.51 | O=C(NCCN1CCC2(CC1)C(=O)NCN2c1ccc(F)cc1)c1cnc2ccccc2c1 | Homo sapiens | CHEMBL1250951 | cell-based format |
| CHEMBL492971 |  |
IC50 | = | 42.0 | nM | 416.88 | O=C(NCCN1CCC(n2c(=O)[nH]c3ccc(F)cc32)CC1)c1ccc(Cl)cc1 | Homo sapiens | CHEMBL957605 | cell-based format |
| CHEMBL4436548 |  |
IC50 | = | 43.0 | nM | 434.52 | O=C(NCCN1CCC2(CC1)C(=O)NC[C@@H]2c1ccc(F)cc1)c1cc2ccccc2[nH]1 | Homo sapiens | CHEMBL4329650 | cell-based format |
| CHEMBL2137046 |  |
IC50 | = | 44.0 | nM | 387.52 | CCC(=C(c1ccc(O)cc1)c1ccc(OCCN(C)C)cc1)c1ccccc1 | Homo sapiens | CHEMBL1220778 | cell-based format |
| CHEMBL1254081 |  |
IC50 | = | 50.0 | nM | 469.95 | O=C(NCCN1CCC2(CC1)C(=O)NCN2c1ccc(Cl)cc1)c1cc2cc(F)ccc2[nH]1 | Homo sapiens | CHEMBL1250951 | cell-based format |
| CHEMBL3923136 |  |
IC50 | = | 60.0 | nM | 446.53 | O=C(NCCN1CCC2(CC1)C(O)=NC[C@H]2c1ccc(F)cc1)c1cnc2ccccc2c1 | Homo sapiens | CHEMBL4329650 | cell-based format |
| CHEMBL1254495 |  |
IC50 | = | 60.0 | nM | 460.55 | C[C@@H](CN1CCC2(CC1)C(=O)NCN2c1cccc(F)c1)NC(=O)c1ccc2ccccc2c1 | Homo sapiens | CHEMBL1250951 | cell-based format |