O14936 | CSKP_HUMAN | Peripheral plasma membrane protein CASK (CASK)
Helixβ‑strandTurn secondary structure
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase | 12–276 | |
| PF00595 | PDZ | 491–567 | |
| PF00625 | Guanylate_kin | 738–911 | |
| PF02828 | L27 | 347–395 | |
| PF02828 | L27 | 406–455 | |
| PF07653 | SH3_2 | 629–674 |
3D structures mapped by conservation among orthologs
[ Domain: "PDZ domain" // PDZ ]
[ Domain: "L27 domain" // L27_like ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Domain: "P-loop containing nucleoside triphosphate hydrolases" // Guanylate_kin ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4762515 |  |
IC50 | = | 80.0 | nM | 596.32 | O=C(NCCCN1CCOC1=O)c1cnc(NCc2cc(Br)ccc2Br)nc1NC1CCCC1 | Homo sapiens | CHEMBL5058546 | single protein format |
| CHEMBL2312304 |  |
IC50 | = | 130.0 | nM | 507.42 | O=C(NCCCN1CCOC1=O)c1cnc(NCc2cc(Cl)ccc2Cl)nc1NC1CCCC1 | Homo sapiens | CHEMBL4831227 | cell-based format |
| CHEMBL2312304 | |
Ki | = | 15.0 | nM | 507.42 | O=C(NCCCN1CCOC1=O)c1cnc(NCc2cc(Cl)ccc2Cl)nc1NC1CCCC1 | Homo sapiens | CHEMBL4831227 | cell-based format |