O14920 | IKKB_HUMAN | Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 16~290 | |
| PF12179 | IKKbetaNEMObind - I-kappa-kinase-beta NEMO binding domain | 706~742 | |
| PF18397 | IKBKB_SDD - IQBAL scaffold dimerization domain | 389~663 |
3D structures mapped by conservation among orthologs
[ Domain: "Inhibitor of kappaB kinase beta dimerization domain" // KOG4250 ]
[ Domain: "Ubiquitin-like" // ubiquitin_4 ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3897289 |  |
IC50 | = | 0.08 | nM | 507.55 | CNc1nccc(-c2cc3cc(C(=O)N[C@@H](CN(c4ccccc4)c4ccccn4)C(=O)O)ccc3[nH]2)n1 | Homo sapiens | CHEMBL3879976 | single protein format |
| CHEMBL1669563 |  |
IC50 | = | 0.6 | nM | 534.98 | COCCNc1cc(C(=O)Nc2ccc3c(c2)-c2c(c(C(N)=O)nn2-c2ccc(F)cc2)CC3)c(Cl)cn1 | Homo sapiens | CHEMBL1670064 | single protein format |
| CHEMBL1669562 |  |
IC50 | = | 0.6 | nM | 561.02 | NC(=O)c1nn(-c2ccc(F)cc2)c2c1CCc1ccc(NC(=O)c3cc(N4CCC(O)CC4)ncc3Cl)cc1-2 | Homo sapiens | CHEMBL1670064 | single protein format |
| CHEMBL1669551 |  |
IC50 | = | 1.2 | nM | 558.04 | CN1CCN(c2cc(C(=O)Nc3ccc4c(c3)-c3c(c(C(N)=O)nn3-c3cccc(O)c3)CC4)c(Cl)cn2)CC1 | Homo sapiens | CHEMBL1670064 | single protein format |
| CHEMBL1669560 |  |
IC50 | = | 2.2 | nM | 592.49 | CN1CCN(c2cc(C(=O)Nc3ccc4c(c3)-c3c(c(C(N)=O)nn3-c3ccc(Cl)c(O)c3)CC4)c(Cl)cn2)CC1 | Homo sapiens | CHEMBL1670064 | single protein format |
| CHEMBL1669559 |  |
IC50 | = | 2.8 | nM | 592.49 | CN1CCN(c2cc(C(=O)Nc3ccc4c(c3)-c3c(c(C(N)=O)nn3-c3ccc(O)c(Cl)c3)CC4)c(Cl)cn2)CC1 | Homo sapiens | CHEMBL1670064 | single protein format |
| CHEMBL182407 |  |
IC50 | = | 3.0 | nM | 364.45 | N#Cc1c(C2CCCNC2)cc(-c2c(O)cccc2OCC2CC2)nc1N | Homo sapiens | CHEMBL833584 | single protein format |
| CHEMBL249280 |  |
IC50 | = | 3.0 | nM | 402.51 | CNc1nc2cc(-c3cccc(CNS(N)(=O)=O)c3)sc2n2c(C)cnc12 | Homo sapiens | CHEMBL888323 | single protein format |
| CHEMBL1669558 |  |
IC50 | = | 3.5 | nM | 558.04 | CN1CCN(c2cc(C(=O)Nc3ccc4c(c3)-c3c(c(C(N)=O)nn3-c3ccc(O)cc3)CC4)c(Cl)cn2)CC1 | Homo sapiens | CHEMBL1670064 | single protein format |
| CHEMBL3946903 |  |
IC50 | = | 3.8 | nM | 508.54 | CNc1nccc(-c2cc3cc(C(=O)N[C@@H](CN(c4ccccc4)c4ncccn4)C(=O)O)ccc3[nH]2)n1 | Homo sapiens | CHEMBL3879976 | single protein format |
| CHEMBL183703 |  |
IC50 | = | 4.0 | nM | 378.48 | N#Cc1c(C2CCCNC2)cc(-c2c(O)cccc2OCC2CCC2)nc1N | Homo sapiens | CHEMBL833584 | single protein format |
| CHEMBL1669556 |  |
IC50 | = | 4.8 | nM | 560.03 | CN1CCN(c2cc(C(=O)Nc3ccc4c(c3)-c3c(c(C(N)=O)nn3-c3cccc(F)c3)CC4)c(Cl)cn2)CC1 | Homo sapiens | CHEMBL1670064 | single protein format |
| CHEMBL181334 |  |
IC50 | = | 5.0 | nM | 352.44 | CCCOc1cccc(O)c1-c1cc(C2CCCNC2)c(C#N)c(N)n1 | Homo sapiens | CHEMBL833584 | single protein format |
| CHEMBL1923988 |  |
IC50 | = | 5.0 | nM | 406.49 | CNc1nc2[nH]c(-c3cccc(CNC(=O)CCN(C)C)n3)cc2c2c1ncn2C | Homo sapiens | CHEMBL1924373 | single protein format |
| CHEMBL493974 |  |
IC50 | = | 5.0 | nM | 402.51 | CNc1nc2sc(-c3cccc(CNS(C)(=O)=O)c3)nc2c2c1ncn2C | Homo sapiens | CHEMBL960916 | single protein format |
| CHEMBL181495 |  |
IC50 | = | 5.0 | nM | 366.47 | CC(C)COc1cccc(O)c1-c1cc(C2CCCNC2)c(C#N)c(N)n1 | Homo sapiens | CHEMBL833584 | single protein format |
| CHEMBL1921823 |  |
IC50 | = | 5.7 | nM | 378.44 | CNC(=O)N(C)Cc1cccc(-c2cc3c(nc(NC)c4ncn(C)c43)[nH]2)n1 | Homo sapiens | CHEMBL1924373 | single protein format |
| CHEMBL521643 |  |
IC50 | = | 6.0 | nM | 295.37 | CNc1nc2sc(-c3ccccc3)nc2c2c1ncn2C | Homo sapiens | CHEMBL960916 | single protein format |
| CHEMBL1642545 |  |
IC50 | = | 6.0 | nM | 380.48 | CNc1nc2sc(-c3cccc([C@H](C)NC(C)=O)c3)nc2c2c1ncn2C | Homo sapiens | CHEMBL1646312 | single protein format |
| CHEMBL182749 |  |
IC50 | = | 6.0 | nM | 380.49 | CCCCCOc1cccc(O)c1-c1cc(C2CCCNC2)c(C#N)c(N)n1 | Homo sapiens | CHEMBL833584 | single protein format |