O14757 | CHK1_HUMAN | Serine/threonine-protein kinase Chk1 (CHEK1)
Pfam Domain Table
Accession | Domain | Range | Color |
---|---|---|---|
PF00069 | Pkinase - Protein kinase domain | 11~264 |
3D structures mapped by conservation among orthologs
[ Domain: "Kinase associated domain 1, KA1" // NAF ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
- 1IA8
- 1NVQ
- 1NVR
- 1NVS
- 1ZLT
- 1ZYS
- 2AYP
- 2BR1
- 2BRB
- 2BRG
- 2BRH
- 2BRM
- 2BRN
- 2BRO
- 2C3J
- 2C3K
- 2C3L
- 2CGU
- 2CGV
- 2CGW
- 2CGX
- 2E9N
- 2E9O
- 2E9P
- 2E9U
- 2E9V
- 2GDO
- 2GHG
- 2HOG
- 2HXL
- 2HXQ
- 2HY0
- 2QHM
- 2QHN
- 2R0U
- 2WMQ
- 2WMR
- 2WMS
- 2WMT
- 2WMU
- 2WMV
- 2WMW
- 2WMX
- 2X8D
- 2X8E
- 2X8I
- 2XEY
- 2XEZ
- 2XF0
- 2YDI
- 2YDJ
- 2YDK
- 2YER
- 2YEX
- 2YM3
- 2YM4
- 2YM5
- 2YM6
- 2YM7
- 2YM8
- 2YWP
- 3F9N
- 3JVR
- 3JVS
- 3NLB
- 3OT3
- 3OT8
- 3PA3
- 3PA4
- 3PA5
- 3TKH
- 3TKI
- 3U9N
- 4FSM
- 4FSN
- 4FSQ
- 4FSR
- 4FST
- 4FSU
- 4FSW
- 4FSY
- 4FSZ
- 4FT0
- 4FT3
- 4FT5
- 4FT7
- 4FT9
- 4FTA
- 4FTC
- 4FTI
- 4FTJ
- 4FTK
- 4FTL
- 4FTM
- 4FTN
- 4FTO
- 4FTQ
- 4FTR
- 4FTT
- 4FTU
- 4GH2
- 4HYH
- 4HYI
- 4JIK
- 4QYE
- 4QYF
- 4QYG
- 4QYH
- 4RVK
- 4RVL
- 4RVM
- 5DLS
- 5F4N
- 5OOP
- 5OOR
- 5OOT
- 5OP2
- 5OP4
- 5OP5
- 5OP7
- 5OPB
- 5OPR
- 5OPS
- 5OPU
- 5OPV
- 5OQ5
- 5OQ6
- 5OQ7
- 5OQ8
- 6FC8
- 6FCF
- 6FCK
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
---|---|---|---|---|---|---|---|---|---|---|
CHEMBL2011353 | IC50 | = | 0.03 | nM | 466.57 | CC(=O)N1CCN(c2ccnc(Nc3ncc(-c4cncc(C(=O)NCCN)c4)s3)c2)CC1 | Homo sapiens | CHEMBL2014579 | single protein format | |
CHEMBL3694397 | IC50 | = | 0.03 | nM | 521.03 | COc1cc(CCNCc2ccc(N3CCNCC3)cc2)c(Cl)cc1NC(=O)Nc1cnc(C#N)cn1 | Homo sapiens | CHEMBL3706261 | organism-based format | |
CHEMBL2011352 | IC50 | = | 0.03 | nM | 502.63 | CS(=O)(=O)N1CCN(c2ccnc(Nc3ncc(-c4cncc(C(=O)NCCN)c4)s3)c2)CC1 | Homo sapiens | CHEMBL2014579 | single protein format | |
CHEMBL2011354 | IC50 | = | 0.05 | nM | 459.53 | NCCNC(=O)c1cncc(-c2cnc(Nc3cc(N4CCC(F)(F)CC4)ccn3)s2)c1 | Homo sapiens | CHEMBL2014248 | single protein format | |
CHEMBL2013170 | IC50 | = | 0.05 | nM | 445.5 | NCNC(=O)c1cncc(-c2cnc(Nc3cc(N4CCC(F)(F)CC4)ccn3)s2)c1 | Homo sapiens | CHEMBL2014579 | single protein format | |
CHEMBL2010809 | IC50 | = | 0.05 | nM | 425.52 | NCCNC(=O)c1cncc(-c2cnc(Nc3cc(N4CCOCC4)ccn3)s2)c1 | Homo sapiens | CHEMBL2014579 | single protein format | |
CHEMBL2011350 | IC50 | = | 0.05 | nM | 424.53 | NCCNC(=O)c1cncc(-c2cnc(Nc3cc(N4CCNCC4)ccn3)s2)c1 | Homo sapiens | CHEMBL2014248 | single protein format | |
CHEMBL2013169 | IC50 | = | 0.07 | nM | 427.51 | NCNC(=O)c1cncc(-c2cnc(Nc3cc(N4CCC(F)CC4)ccn3)s2)c1 | Homo sapiens | CHEMBL2014579 | single protein format | |
CHEMBL247646 | IC50 | = | 0.1 | nM | 444.49 | COc1cc2c(cc1OC[C@@H](O)CO)Cc1c-2n[nH]c1-c1ccc(-c2ccc(O)cc2)cc1 | Homo sapiens | CHEMBL888355 | single protein format | |
CHEMBL248012 | IC50 | = | 0.1 | nM | 444.49 | COc1cc2c(cc1OC[C@H](O)CO)Cc1c-2n[nH]c1-c1ccc(-c2ccc(O)cc2)cc1 | Homo sapiens | CHEMBL888355 | single protein format | |
CHEMBL248194 | IC50 | < | 0.1 | nM | 444.49 | COc1cc2c(cc1OC(CO)CO)Cc1c-2n[nH]c1-c1ccc(-c2ccc(O)cc2)cc1 | Homo sapiens | CHEMBL888355 | single protein format | |
CHEMBL1223526 | IC50 | = | 0.1 | nM | 264.29 | Cc1cc2n[nH]c(=O)n2c2cc(-c3ccc[nH]3)ccc12 | Homo sapiens | CHEMBL1228388 | cell-based format | |
CHEMBL219789 | IC50 | = | 0.11 | nM | 444.52 | NCc1nn[nH]c1-c1ccc2c(-c3cc4cc(CN5CCC(F)CC5)ccc4[nH]3)n[nH]c2c1 | Homo sapiens | CHEMBL855120 | single protein format | |
CHEMBL3694385 | IC50 | = | 0.13 | nM | 535.05 | COc1cc(CCN[C@@H](C)c2ccc(N3CCNCC3)cc2)c(Cl)cc1NC(=O)Nc1cnc(C#N)cn1 | Homo sapiens | CHEMBL3706261 | organism-based format | |
CHEMBL247825 | IC50 | = | 0.2 | nM | 454.53 | COc1cc2c(cc1OC1CCOCC1)Cc1c-2n[nH]c1-c1ccc(-c2ccc(O)cc2)cc1 | Homo sapiens | CHEMBL888355 | single protein format | |
CHEMBL248036 | IC50 | = | 0.2 | nM | 510.64 | COc1cc2c(cc1OCCCN1CCN(C)CC1)-c1n[nH]c(-c3ccc(-c4ccc(O)cc4)cc3)c1C2 | Homo sapiens | CHEMBL888355 | single protein format | |
CHEMBL232810 | IC50 | = | 0.21 | nM | 480.61 | COc1cc2c(cc1CNCCN1CCCC1)Cc1c(-c3ccc(-c4ccc(O)cc4)cc3)n[nH]c1-2 | Homo sapiens | CHEMBL896339 | single protein format | |
CHEMBL3694387 | IC50 | = | 0.23 | nM | 480.91 | COc1cc(CCNCc2ccc3c(c2)OCO3)c(Cl)cc1NC(=O)Nc1cnc(C#N)cn1 | Homo sapiens | CHEMBL3706261 | organism-based format | |
CHEMBL428196 | IC50 | = | 0.24 | nM | 495.58 | COc1cc2c(cc1C(=O)N[C@H]1CC[C@H](O)CC1)Cc1c(-c3ccc(-c4ccc(O)cc4)cc3)n[nH]c1-2 | Homo sapiens | CHEMBL896339 | single protein format | |
CHEMBL234868 | IC50 | = | 0.24 | nM | 481.55 | COc1cc2c(cc1C(=O)N1CCC(O)CC1)Cc1c(-c3ccc(-c4ccc(O)cc4)cc3)n[nH]c1-2 | Homo sapiens | CHEMBL896339 | single protein format |