O14757 | CHK1_HUMAN | Serine/threonine-protein kinase Chk1 (CHEK1)

Pfam Domain Table

AccessionDomainRangeColor
PF00069Pkinase - Protein kinase domain11~264

3D structures mapped by conservation among orthologs

[ Domain: "Kinase associated domain 1, KA1" // NAF ]

 PyMOL session

[ Domain: "Protein kinase" // Pkinase_Tyr ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV    Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL2011353 IC50 = 0.03 nM 466.57 CC(=O)N1CCN(c2ccnc(Nc3ncc(-c4cncc(C(=O)NCCN)c4)s3)c2)CC1 Homo sapiens CHEMBL2014579 single protein format
CHEMBL3694397 IC50 = 0.03 nM 521.03 COc1cc(CCNCc2ccc(N3CCNCC3)cc2)c(Cl)cc1NC(=O)Nc1cnc(C#N)cn1 Homo sapiens CHEMBL3706261 organism-based format
CHEMBL2011352 IC50 = 0.03 nM 502.63 CS(=O)(=O)N1CCN(c2ccnc(Nc3ncc(-c4cncc(C(=O)NCCN)c4)s3)c2)CC1 Homo sapiens CHEMBL2014579 single protein format
CHEMBL2011354 IC50 = 0.05 nM 459.53 NCCNC(=O)c1cncc(-c2cnc(Nc3cc(N4CCC(F)(F)CC4)ccn3)s2)c1 Homo sapiens CHEMBL2014248 single protein format
CHEMBL2013170 IC50 = 0.05 nM 445.5 NCNC(=O)c1cncc(-c2cnc(Nc3cc(N4CCC(F)(F)CC4)ccn3)s2)c1 Homo sapiens CHEMBL2014579 single protein format
CHEMBL2010809 IC50 = 0.05 nM 425.52 NCCNC(=O)c1cncc(-c2cnc(Nc3cc(N4CCOCC4)ccn3)s2)c1 Homo sapiens CHEMBL2014579 single protein format
CHEMBL2011350 IC50 = 0.05 nM 424.53 NCCNC(=O)c1cncc(-c2cnc(Nc3cc(N4CCNCC4)ccn3)s2)c1 Homo sapiens CHEMBL2014248 single protein format
CHEMBL2013169 IC50 = 0.07 nM 427.51 NCNC(=O)c1cncc(-c2cnc(Nc3cc(N4CCC(F)CC4)ccn3)s2)c1 Homo sapiens CHEMBL2014579 single protein format
CHEMBL247646 IC50 = 0.1 nM 444.49 COc1cc2c(cc1OC[C@@H](O)CO)Cc1c-2n[nH]c1-c1ccc(-c2ccc(O)cc2)cc1 Homo sapiens CHEMBL888355 single protein format
CHEMBL248012 IC50 = 0.1 nM 444.49 COc1cc2c(cc1OC[C@H](O)CO)Cc1c-2n[nH]c1-c1ccc(-c2ccc(O)cc2)cc1 Homo sapiens CHEMBL888355 single protein format
CHEMBL248194 IC50 < 0.1 nM 444.49 COc1cc2c(cc1OC(CO)CO)Cc1c-2n[nH]c1-c1ccc(-c2ccc(O)cc2)cc1 Homo sapiens CHEMBL888355 single protein format
CHEMBL1223526 IC50 = 0.1 nM 264.29 Cc1cc2n[nH]c(=O)n2c2cc(-c3ccc[nH]3)ccc12 Homo sapiens CHEMBL1228388 cell-based format
CHEMBL219789 IC50 = 0.11 nM 444.52 NCc1nn[nH]c1-c1ccc2c(-c3cc4cc(CN5CCC(F)CC5)ccc4[nH]3)n[nH]c2c1 Homo sapiens CHEMBL855120 single protein format
CHEMBL3694385 IC50 = 0.13 nM 535.05 COc1cc(CCN[C@@H](C)c2ccc(N3CCNCC3)cc2)c(Cl)cc1NC(=O)Nc1cnc(C#N)cn1 Homo sapiens CHEMBL3706261 organism-based format
CHEMBL247825 IC50 = 0.2 nM 454.53 COc1cc2c(cc1OC1CCOCC1)Cc1c-2n[nH]c1-c1ccc(-c2ccc(O)cc2)cc1 Homo sapiens CHEMBL888355 single protein format
CHEMBL248036 IC50 = 0.2 nM 510.64 COc1cc2c(cc1OCCCN1CCN(C)CC1)-c1n[nH]c(-c3ccc(-c4ccc(O)cc4)cc3)c1C2 Homo sapiens CHEMBL888355 single protein format
CHEMBL232810 IC50 = 0.21 nM 480.61 COc1cc2c(cc1CNCCN1CCCC1)Cc1c(-c3ccc(-c4ccc(O)cc4)cc3)n[nH]c1-2 Homo sapiens CHEMBL896339 single protein format
CHEMBL3694387 IC50 = 0.23 nM 480.91 COc1cc(CCNCc2ccc3c(c2)OCO3)c(Cl)cc1NC(=O)Nc1cnc(C#N)cn1 Homo sapiens CHEMBL3706261 organism-based format
CHEMBL428196 IC50 = 0.24 nM 495.58 COc1cc2c(cc1C(=O)N[C@H]1CC[C@H](O)CC1)Cc1c(-c3ccc(-c4ccc(O)cc4)cc3)n[nH]c1-2 Homo sapiens CHEMBL896339 single protein format
CHEMBL234868 IC50 = 0.24 nM 481.55 COc1cc2c(cc1C(=O)N1CCC(O)CC1)Cc1c(-c3ccc(-c4ccc(O)cc4)cc3)n[nH]c1-2 Homo sapiens CHEMBL896339 single protein format