O14746 | TERT_HUMAN | Telomerase reverse transcriptase (TERT)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00078 | RVT_1 - Reverse transcriptase (RNA-dependent DNA polymerase) | 822~905 | |
| PF12009 | Telomerase_RBD - Telomerase ribonucleoprotein complex - RNA binding domain | 460~592 | |
| PF21399 | TERT_C - Telomerase reverse transcriptase, C-terminal extension | 968~1097 |
3D structures mapped by conservation among orthologs
[ Domain: "helical bundle domain in reverse transcriptase-like polymerases" // KOG1005 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL443683 |  |
IC50 | = | 0.64 | nM | 582.51 | Cc1oc2nc1-c1nc(co1)-c1nc(co1)-c1nc(co1)-c1nc(co1)-c1nc(co1)C1=NC(CS1)c1nc-2c(C)o1 | Homo sapiens | CHEMBL926068 | cell-based format |
| CHEMBL259739 |  |
IC50 | = | 1.5 | nM | 550.62 | C[n+]1cc(NC(=O)c2ccc3ccc4ccc(C(=O)Nc5cc6ccccc6[n+](C)c5)nc4c3n2)cc2ccccc21 | Homo sapiens | CHEMBL926068 | cell-based format |
| CHEMBL3347538 |  |
IC50 | = | 5.0 | nM | 582.51 | Cc1oc2nc1-c1nc(co1)-c1nc(co1)-c1nc(co1)-c1nc(co1)-c1nc(co1)C1=N[C@H](CS1)c1nc-2c(C)o1 | Homo sapiens | CHEMBL3391067 | single protein format |
| CHEMBL3948172 |  |
IC50 | = | 12.6 | nM | 198.22 | CC1CCCC2(OC(O)C=CC2=O)O1 | Homo sapiens | CHEMBL3862957 | cell-based format |
| CHEMBL1078511 |  |
IC50 | = | 18.0 | nM | 585.8 | CN1CCCC1CCNc1c2ccc(NC(=O)CCN3CCCC3)cc2nc2cc(NC(=O)CCN3CCCC3)ccc12 | Homo sapiens | CHEMBL1105835 | cell-based format |
| CHEMBL140180 |  |
IC50 | = | 18.0 | nM | 545.73 | CN(C)CCNc1c2ccc(NC(=O)CCN3CCCC3)cc2nc2cc(NC(=O)CCN3CCCC3)ccc12 | Homo sapiens | CHEMBL1105835 | cell-based format |
| CHEMBL3347541 |  |
IC50 | = | 20.0 | nM | 597.5 | NCCCC[C@@H]1NC(=O)c2coc(n2)-c2coc(n2)-c2coc(n2)-c2coc(n2)-c2coc(n2)-c2coc(n2)-c2coc1n2 | Homo sapiens | CHEMBL3391067 | single protein format |
| CHEMBL139511 |  |
IC50 | = | 20.0 | nM | 565.72 | Nc1ccccc1Nc1c2ccc(NC(=O)CCN3CCCC3)cc2nc2cc(NC(=O)CCN3CCCC3)ccc12 | Homo sapiens | CHEMBL1105835 | cell-based format |
| CHEMBL2425367 |  |
IC50 | = | 28.0 | nM | 508.71 | CN(C)CCCNCc1ccc2nc3ccc4cc5cc(CNCCCN(C)C)ccc5nc4c3cc2c1 | Homo sapiens | CHEMBL2427719 | single protein format |
| CHEMBL224754 |  |
IC50 | = | 30.0 | nM | 562.67 | C[N+](C)(C)CCN1C(=O)c2ccc3c4ccc5c6c(ccc(c7ccc(c2c37)C1=O)c64)C(=O)N(CC[N+](C)(C)C)C5=O | Homo sapiens | CHEMBL918789 | cell-based format |
| CHEMBL336444 |  |
IC50 | = | 40.0 | nM | 592.74 | CC(=O)c1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1 | Homo sapiens | CHEMBL1105835 | cell-based format |
| CHEMBL2260109 |  |
IC50 | = | 41.0 | nM | 525.69 | CSc1nc(Nc2ccc3nc(C)cc(N(C)C)c3c2)nc(Nc2ccc3nc(C)cc(N(C)C)c3c2)n1 | Homo sapiens | CHEMBL3070227 | single protein format |
| CHEMBL336434 |  |
IC50 | = | 45.0 | nM | 593.78 | CN(C)c1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1 | Homo sapiens | CHEMBL926068 | cell-based format |
| CHEMBL2298058 |  |
IC50 | = | 49.0 | nM | 469.58 | CSc1nc(Nc2ccc3nc(C)cc(N)c3c2)nc(Nc2ccc3nc(C)cc(N)c3c2)n1 | Homo sapiens | CHEMBL3070227 | single protein format |
| CHEMBL138811 |  |
IC50 | = | 50.0 | nM | 514.67 | O=C(CCN1CCCC1)Nc1ccc2c(NC3CC3)c3ccc(NC(=O)CCN4CCCC4)cc3nc2c1 | Homo sapiens | CHEMBL1105835 | cell-based format |
| CHEMBL3330787 |  |
IC50 | = | 50.0 | nM | 473.0 | CNCCNc1c2c(c(NCCNC(=N)N)c3sccc13)C(=O)c1ccccc1C2=O.Cl | Homo sapiens | CHEMBL3364665 | cell-based format |
| CHEMBL141540 |  |
IC50 | = | 50.0 | nM | 585.8 | O=C(CCN1CCCC1)Nc1ccc2c(NCCN3CCCCC3)c3ccc(NC(=O)CCN4CCCC4)cc3nc2c1 | Homo sapiens | CHEMBL1105835 | cell-based format |
| CHEMBL2298055 |  |
IC50 | = | 51.0 | nM | 438.5 | Cc1cc(N)c2cc(Nc3nc(N)nc(Nc4ccc5nc(C)cc(N)c5c4)n3)ccc2n1 | Homo sapiens | CHEMBL3070227 | single protein format |
| CHEMBL409247 |  |
IC50 | = | 52.0 | nM | 449.51 | C[n+]1cc(NC(=O)c2cccc(C(=O)Nc3cc4ccccc4[n+](C)c3)n2)cc2ccccc21 | Homo sapiens | CHEMBL926068 | cell-based format |
| CHEMBL2298050 |  |
IC50 | = | 56.0 | nM | 496.62 | CC[n+]1c(C)cc(N)c2cc(Nc3nc(N)nc(Nc4ccc5c(c4)c(N)cc(C)[n+]5CC)n3)ccc21 | Homo sapiens | CHEMBL3070227 | single protein format |