O14733 | MP2K7_HUMAN | Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 122~380 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3329977 |  |
IC50 | = | 1.9 | nM | 293.28 | O=C(O)c1cccc(NC2=CC(=O)c3ccccc3C2=O)c1 | Homo sapiens | CHEMBL4725965 | single protein format |
| CHEMBL5174214 |  |
IC50 | = | 3.0 | nM | 513.94 | C=CC(=O)N1CCC[C@@H](n2nc(-c3cn(CC(F)(F)c4ccc(Cl)cc4)nn3)c3c(N)ncnc32)C1 | Homo sapiens | CHEMBL5125990 | assay format |
| CHEMBL5195838 |  |
IC50 | = | 4.0 | nM | 479.5 | C=CC(=O)N1CCC[C@@H](n2nc(-c3cn(CC(F)(F)c4ccccc4)nn3)c3c(N)ncnc32)C1 | Homo sapiens | CHEMBL5125990 | assay format |
| CHEMBL4749823 |  |
IC50 | = | 5.0 | nM | 277.33 | C=CC(=O)Nc1cccc(-c2n[nH]c3cc(C)ccc23)c1 | Homo sapiens | CHEMBL4702206 | single protein format |
| CHEMBL3901151 |  |
IC50 | = | 6.0 | nM | 263.3 | C=CC(=O)Nc1cccc(-c2n[nH]c3ccccc23)c1 | Homo sapiens | CHEMBL4725965 | single protein format |
| CHEMBL4764965 |  |
IC50 | = | 6.5 | nM | 344.37 | C#CCNC(=O)c1cc(NC(=O)C=C)cc(-c2n[nH]c3ccccc23)c1 | Homo sapiens | CHEMBL4702206 | single protein format |
| CHEMBL5284723 |  |
IC50 | = | 10.0 | nM | 368.82 | O=C(CCl)Nc1cccc(Oc2cc(NCc3ccccc3)ncn2)c1 | Homo sapiens | CHEMBL5260478 | single protein format |
| CHEMBL4787266 |  |
IC50 | = | 14.0 | nM | 308.3 | C=CC(=O)Nc1cccc(-c2n[nH]c3cc([N+](=O)[O-])ccc23)c1 | Homo sapiens | CHEMBL4725965 | single protein format |
| CHEMBL4071151 |  |
IC50 | = | 30.0 | nM | 296.33 | C#Cc1nn([C@@H]2CCCN(C(=O)C=C)C2)c2ncnc(N)c12 | Homo sapiens | CHEMBL5125990 | assay format |
| CHEMBL5169325 |  |
IC50 | = | 30.0 | nM | 499.58 | C=CC(=O)Nc1cc(C(=O)NCc2cn([C@@H]3CCCC[C@H]3OC)nn2)cc(-c2n[nH]c3ccccc23)c1 | Homo sapiens | CHEMBL5125990 | assay format |
| CHEMBL5283781 |  |
IC50 | = | 42.0 | nM | 404.8 | O=C(CCl)Nc1cccc(Oc2cc(NCc3ccc(F)c(F)c3)ncn2)c1 | Homo sapiens | CHEMBL5260478 | single protein format |
| CHEMBL5271442 |  |
IC50 | = | 60.0 | nM | 292.73 | CNc1cc(Oc2cccc(NC(=O)CCl)c2)ncn1 | Homo sapiens | CHEMBL5260478 | single protein format |
| CHEMBL5267499 |  |
IC50 | = | 66.0 | nM | 417.3 | O=C(CCl)Nc1cccc(Oc2cc(NCCc3ccc(Cl)cc3)ncn2)c1 | Homo sapiens | CHEMBL5260478 | single protein format |
| CHEMBL5279577 |  |
IC50 | = | 74.0 | nM | 404.8 | O=C(CCl)Nc1cccc(Oc2cc(NCc3cc(F)cc(F)c3)ncn2)c1 | Homo sapiens | CHEMBL5260478 | single protein format |
| CHEMBL4866649 |  |
IC50 | = | 96.0 | nM | 410.43 | NC(=O)c1ccc(NS(=O)(=O)c2cccc(-c3n[nH]c4cc(F)ccc34)c2)cc1 | Homo sapiens | CHEMBL4840155 | cell-based format |
| CHEMBL5271266 |  |
IC50 | = | 110.0 | nM | 382.85 | CN(Cc1ccccc1)c1cc(Oc2cccc(NC(=O)CCl)c2)ncn1 | Homo sapiens | CHEMBL5260478 | single protein format |
| CHEMBL5267684 |  |
IC50 | = | 110.0 | nM | 422.79 | O=C(CCl)Nc1cccc(Oc2cc(NCc3c(F)ccc(F)c3F)ncn2)c1 | Homo sapiens | CHEMBL5260478 | single protein format |
| CHEMBL4095253 |  |
IC50 | = | 188.6 | nM | 427.49 | C=CS(=O)(=O)N1CCC[C@@H]1Cn1cc(-c2ccc3c(c2)OCO3)c2c(N)ncnc21 | Homo sapiens | CHEMBL4058128 | assay format |
| CHEMBL100206 |  |
IC50 | = | 230.0 | nM | 262.29 | O=C(O)CCSC1=CC(=O)c2ccccc2C1=O | Homo sapiens | CHEMBL4725965 | single protein format |
| CHEMBL574738 |  |
IC50 | = | 260.0 | nM | 529.57 | CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 | Homo sapiens | CHEMBL5260478 | single protein format |