O14684 | PTGES_HUMAN | Prostaglandin E synthase (PTGES)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01124 | MAPEG - MAPEG family | 17~146 |
3D structures mapped by conservation among orthologs
[ Domain: "MAPEG domain-like" // MAPEG ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3896436 |  |
IC50 | = | 0.1 | nM | 588.92 | COCC(C)(C)CNc1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3cc(Cl)ccc3Cl)cc2[nH]1 | Homo sapiens | CHEMBL3887736 | cell-based format |
| CHEMBL3342696 |  |
IC50 | = | 0.1 | nM | 551.35 | COCc1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3c(Cl)cccc3C(F)(F)F)cc2[nH]1 | Homo sapiens | CHEMBL3388007 | single protein format |
| CHEMBL3971013 |  |
IC50 | = | 0.1 | nM | 474.46 | COCc1nc2c(C(=O)Nc3cccs3)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 | Homo sapiens | CHEMBL3887736 | cell-based format |
| CHEMBL3956115 |  |
IC50 | = | 0.2 | nM | 528.96 | Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(C(C)(C)C)nc12 | Homo sapiens | CHEMBL3887736 | cell-based format |
| CHEMBL3981545 |  |
IC50 | = | 0.2 | nM | 558.0 | Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(NCC(C)(C)C)nc12 | Homo sapiens | CHEMBL3887736 | cell-based format |
| CHEMBL3930662 |  |
IC50 | = | 0.3 | nM | 541.96 | Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(N3CCCC3)nc12 | Homo sapiens | CHEMBL3887736 | cell-based format |
| CHEMBL3899486 |  |
IC50 | = | 0.3 | nM | 588.03 | Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(NCCOC(C)(C)C)nc12 | Homo sapiens | CHEMBL3887736 | cell-based format |
| CHEMBL3962760 |  |
IC50 | = | 0.3 | nM | 507.3 | Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(Cl)nc12 | Homo sapiens | CHEMBL3887736 | cell-based format |
| CHEMBL3897304 |  |
IC50 | = | 0.4 | nM | 558.44 | Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2c(F)cccc2Cl)cc2[nH]c(NCCOC(C)C)nc12 | Homo sapiens | CHEMBL3887736 | cell-based format |
| CHEMBL3979324 |  |
IC50 | = | 0.4 | nM | 542.99 | Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(CC(C)(C)C)nc12 | Homo sapiens | CHEMBL3887736 | cell-based format |
| CHEMBL3926077 |  |
IC50 | = | 0.4 | nM | 574.9 | Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2cc(Cl)ccc2Cl)cc2[nH]c(NCCOC(C)C)nc12 | Homo sapiens | CHEMBL3887736 | cell-based format |
| CHEMBL567696 |  |
IC50 | = | 0.4 | nM | 502.62 | CC(C)CCOc1ccc2c(c1)c1cc(CC(C)(C)O)ccc1c1[nH]c(-c3c(C#N)cccc3C#N)nc21 | Homo sapiens | CHEMBL1050553 | cell-based format |
| CHEMBL3952794 |  |
IC50 | = | 0.4 | nM | 555.99 | Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(NC3CCCC3)nc12 | Homo sapiens | CHEMBL3887736 | cell-based format |
| CHEMBL3892483 |  |
IC50 | = | 0.4 | nM | 555.99 | Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(N3CCCCC3)nc12 | Homo sapiens | CHEMBL3887736 | cell-based format |
| CHEMBL3960895 |  |
IC50 | = | 0.5 | nM | 558.44 | Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2c(F)cccc2Cl)cc2[nH]c(NC(CO)C(C)C)nc12 | Homo sapiens | CHEMBL3887736 | cell-based format |
| CHEMBL3970074 |  |
IC50 | = | 0.5 | nM | 526.95 | Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(C3(C)CC3)nc12 | Homo sapiens | CHEMBL3887736 | cell-based format |
| CHEMBL3920661 |  |
IC50 | = | 0.5 | nM | 563.41 | Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(C(C)(C)CCl)nc12 | Homo sapiens | CHEMBL3887736 | cell-based format |
| CHEMBL3962924 |  |
IC50 | = | 0.7 | nM | 513.81 | Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2cc(Cl)ccc2Cl)cc2[nH]c(C3CC3)nc12 | Homo sapiens | CHEMBL3887736 | cell-based format |
| CHEMBL483894 |  |
IC50 | = | 0.8 | nM | 520.71 | Fc1cccc(Cl)c1-c1nc(-c2ccc(C#Cc3ccc(C(F)(F)F)cc3)nc2)c(Br)[nH]1 | Homo sapiens | CHEMBL1100219 | single protein format |
| CHEMBL3984205 |  |
IC50 | = | 0.8 | nM | 557.02 | CCCC(C)(C)c1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 | Homo sapiens | CHEMBL3887736 | cell-based format |