O14649 | KCNK3_HUMAN | Potassium channel subfamily K member 3 (KCNK3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF07885 | Ion_trans_2 - Ion channel | 77~132 | |
| PF07885 | Ion_trans_2 - Ion channel | 167~243 |
3D structures mapped by conservation among orthologs
[ Domain: "Voltage-gated ion channels" // Ion_trans_2_1 ]
[ Domain: "Voltage-gated ion channels" // Ion_trans_2 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3182699 |  |
IC50 | = | 1.0 | nM | 458.44 | CC(C)Oc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2OC(F)(F)F)c1 | Homo sapiens | CHEMBL3367860 | cell-based format |
| CHEMBL3183497 |  |
IC50 | = | 2.0 | nM | 390.44 | CCOc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2OC)c1 | Homo sapiens | CHEMBL3367860 | cell-based format |
| CHEMBL3182449 |  |
IC50 | = | 2.0 | nM | 428.41 | CCOc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2C(F)(F)F)c1 | Homo sapiens | CHEMBL3367860 | cell-based format |
| CHEMBL1086899 |  |
IC50 | = | 3.0 | nM | 364.83 | Cc1cccc(C(=O)Nc2cccc(NC(=O)c3cccc(Cl)c3)c2)c1 | Homo sapiens | CHEMBL3367860 | cell-based format |
| CHEMBL3188749 |  |
IC50 | = | 4.0 | nM | 430.38 | COc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2OC(F)(F)F)c1 | Homo sapiens | CHEMBL3367860 | cell-based format |
| CHEMBL1081188 |  |
IC50 | = | 4.0 | nM | 360.41 | COc1ccccc1C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1 | Homo sapiens | CHEMBL3367860 | cell-based format |
| CHEMBL3182091 |  |
IC50 | = | 5.0 | nM | 336.42 | Cc1cccc(C(=O)Nc2cccc(NC(=O)c3cccs3)c2)c1 | Homo sapiens | CHEMBL3367860 | cell-based format |
| CHEMBL148342 |  |
IC50 | = | 7.0 | nM | 500.55 | COc1ccc(CC(=O)NCc2ccccc2-c2ccccc2C(=O)NCc2ccc(F)cc2F)cc1 | Homo sapiens | CHEMBL3367860 | cell-based format |
| CHEMBL3187764 |  |
IC50 | = | 7.0 | nM | 388.47 | COc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2C(C)C)c1 | Homo sapiens | CHEMBL3367860 | cell-based format |
| CHEMBL3187482 |  |
IC50 | = | 9.0 | nM | 374.44 | CCOc1ccccc1C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1 | Homo sapiens | CHEMBL3367860 | cell-based format |
| CHEMBL3182359 |  |
IC50 | = | 10.0 | nM | 376.41 | COc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2OC)c1 | Homo sapiens | CHEMBL3367860 | cell-based format |
| CHEMBL3183773 |  |
IC50 | = | 10.0 | nM | 398.38 | Cc1cccc(C(=O)Nc2cccc(NC(=O)c3cccc(C(F)(F)F)c3)c2)c1 | Homo sapiens | CHEMBL3367860 | cell-based format |
| CHEMBL3186000 |  |
IC50 | = | 11.0 | nM | 442.44 | CC(C)c1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2OC(F)(F)F)c1 | Homo sapiens | CHEMBL3367860 | cell-based format |
| CHEMBL4113638 |  |
IC50 | = | 13.0 | nM | 443.59 | CC[C@H](NC(=O)c1cc(C(=O)N[C@H](CC)c2ccccc2)c2n1CCCC2)c1ccccc1 | Homo sapiens | CHEMBL3888209 | cell-based format |
| CHEMBL4108886 |  |
IC50 | = | 13.0 | nM | 421.54 | CC[C@@H](NC(=O)c1cc(C(=O)NC(C2CC2)C2CC2)n2c1COCC2)c1ccccc1 | Homo sapiens | CHEMBL3888209 | cell-based format |
| CHEMBL3916254 |  |
IC50 | = | 13.0 | nM | 497.95 | CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2c1COCC2)c1ccc(C(F)(F)F)c(Cl)c1 | Homo sapiens | CHEMBL3888209 | cell-based format |
| CHEMBL3188857 |  |
IC50 | = | 14.0 | nM | 398.38 | Cc1cccc(C(=O)Nc2cccc(NC(=O)c3ccccc3C(F)(F)F)c2)c1 | Homo sapiens | CHEMBL3367860 | cell-based format |
| CHEMBL3967700 |  |
IC50 | = | 15.0 | nM | 447.94 | CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2c1COCC2)c1ccc(F)c(Cl)c1 | Homo sapiens | CHEMBL3888209 | cell-based format |
| CHEMBL3940405 |  |
IC50 | = | 19.0 | nM | 420.46 | CC(C)C(=O)N1CCc2c(c(-c3cccc(C#N)c3)nn2Cc2ccc(F)cc2F)C1 | Homo sapiens | CHEMBL3887241 | cell-based format |
| CHEMBL3893027 |  |
IC50 | = | 21.0 | nM | 469.53 | CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2c1COCC2)c1ccc(C(F)(F)F)s1 | Homo sapiens | CHEMBL3888209 | cell-based format |