O14638 | ENPP3_HUMAN | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01033 | Somatomedin_B - Somatomedin B domain | 53~91 | |
| PF01033 | Somatomedin_B - Somatomedin B domain | 96~136 | |
| PF01663 | Phosphodiest - Type I phosphodiesterase / nucleotide pyrophosphatase | 161~486 |
3D structures mapped by conservation among orthologs
[ Domain: "Phosphonoacetate hydrolase insertion domain" // Phosphodiest_C ]
[ Domain: "Alkaline phosphatase-like" // Phosphodiest_N ]
[ Domain: "His-Me finger endonucleases" // Endonuclease_NS ]
[ Domain: "Somatomedin B domain" // Somatomedin_B ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4753995 |  |
IC50 | = | 150.0 | nM | 285.35 | Cc1nc(-c2ccc(-c3cccc4ccccc34)cc2)co1 | Homo sapiens | CHEMBL4710184 | cell membrane format |
| CHEMBL4791706 |  |
IC50 | = | 170.0 | nM | 265.31 | COc1ccc(-c2ccc(-c3coc(C)n3)cc2)cc1 | Homo sapiens | CHEMBL4710184 | cell membrane format |
| CHEMBL4859945 |  |
IC50 | = | 210.0 | nM | 498.01 | Oc1ccc(-c2nn(-c3cccc(NC(=S)Nc4ccccc4)c3)cc2-c2ccncc2)cc1Cl | Homo sapiens | CHEMBL4817261 | cell-based format |
| CHEMBL4573280 |  |
IC50 | = | 214.0 | nM | 455.5 | O=C(Nc1ccc(OS(=O)(=O)c2ccc(C(F)(F)F)cc2)cc1)C1CCCCCCC1 | Homo sapiens | CHEMBL4342162 | assay format |
| CHEMBL4280275 |  |
IC50 | = | 230.0 | nM | 248.71 | Cc1ccc(C(=O)n2nc(C)c(Cl)c2C)cc1 | Homo sapiens | CHEMBL4273107 | cell-based format |
| CHEMBL4585698 |  |
IC50 | = | 254.0 | nM | 377.44 | O=C(Nc1ccc(OS(=O)(=O)c2ccc(F)cc2)cc1)C1CCCCC1 | Homo sapiens | CHEMBL4342162 | assay format |
| CHEMBL4451311 |  |
IC50 | = | 255.0 | nM | 387.5 | Cc1ccc(S(=O)(=O)Oc2ccc(NC(=O)C3CCCCCC3)cc2)cc1 | Homo sapiens | CHEMBL4342162 | assay format |
| CHEMBL4285649 |  |
IC50 | = | 320.0 | nM | 248.71 | Cc1ccccc1C(=O)n1nc(C)c(Cl)c1C | Homo sapiens | CHEMBL4273107 | cell-based format |
| CHEMBL298036 |  |
IC50 | = | 350.0 | nM | 201.23 | Cc1cc(C)n(C(=O)c2ccncc2)n1 | Homo sapiens | CHEMBL4273107 | cell-based format |
| CHEMBL4162261 |  |
IC50 | = | 360.0 | nM | 446.65 | COc1ccc(OC)c(-c2cccc3c(Cl)c(Br)c(C(F)(F)F)nc23)c1 | Homo sapiens | CHEMBL4131383 | assay format |
| CHEMBL3797764 |  |
IC50 | = | 369.0 | nM | 311.4 | CCS(=O)(=O)Oc1ccc(NC(=O)C2CCCCC2)cc1 | Homo sapiens | CHEMBL4342162 | assay format |
| CHEMBL4159530 |  |
IC50 | = | 390.0 | nM | 389.4 | FC(F)(F)c1nc2c(Br)cccc2c(Cl)c1Br | Homo sapiens | CHEMBL4131383 | assay format |
| CHEMBL4280333 |  |
IC50 | = | 410.0 | nM | 217.23 | Cc1cc(=O)n(C(=O)c2ccc(N)cc2)[nH]1 | Homo sapiens | CHEMBL4273107 | cell-based format |
| CHEMBL4283786 |  |
IC50 | = | 510.0 | nM | 321.38 | Cc1ccc(Oc2c(C)nn(C(=O)c3ccc(N)cc3)c2C)cc1 | Homo sapiens | CHEMBL4273107 | cell-based format |
| CHEMBL4848343 |  |
IC50 | = | 550.0 | nM | 344.4 | CN(C)c1ccnc2c1ccn2C(=O)NS(=O)(=O)c1ccccc1 | Homo sapiens | CHEMBL4817263 | cell-based format |
| CHEMBL4850521 |  |
IC50 | = | 590.0 | nM | 394.25 | Cc1ccc(S(=O)(=O)NC(=O)n2ccc3cc(Br)cnc32)cc1 | Homo sapiens | CHEMBL4817263 | cell-based format |
| CHEMBL243638 |  |
IC50 | = | 630.0 | nM | 269.13 | Cc1nn(C(=O)c2ccc(Cl)cc2)c(C)c1Cl | Homo sapiens | CHEMBL4273107 | cell-based format |
| CHEMBL5432925 |  |
IC50 | = | 740.0 | nM | 429.51 | O=C(Nc1ccc(OS(=O)(=O)c2ccc(F)cc2)cc1)C12CC3CC(CC(C3)C1)C2 | Homo sapiens | CHEMBL5332749 | cell-based format |
| CHEMBL4476115 |  |
IC50 | = | 807.0 | nM | 415.56 | CC(C)(C)c1ccc(S(=O)(=O)Oc2ccc(NC(=O)C3CCCCC3)cc2)cc1 | Homo sapiens | CHEMBL4342162 | assay format |
| CHEMBL3798550 |  |
IC50 | = | 856.0 | nM | 359.45 | Cc1ccc(S(=O)(=O)Oc2ccc(NC(=O)C3CCCC3)cc2)cc1 | Homo sapiens | CHEMBL4342162 | assay format |