ProtHub

O00763 | ACACB_HUMAN | Acetyl-CoA carboxylase 2 (ACACB)

Pfam Domain Table

Accession	Domain	Range
PF00289	Biotin_carb_N - Biotin carboxylase, N-terminal domain	260~379
PF00364	Biotin_lipoyl - Biotin-requiring enzyme	896~961
PF01039	Carboxyl_trans - Carboxyl transferase domain	1780~2333
PF02785	Biotin_carb_C - Biotin carboxylase C-terminal domain	651~757
PF02786	CPSase_L_D2 - Carbamoyl-phosphate synthase L chain, ATP binding domain	431~614
PF08326	ACC_central - Acetyl-CoA carboxylase, central region	962~1688
PF21385	ACCA_BT - Acetyl-CoA carboxylase, BT domain	770~889

3D structures mapped by conservation among orthologs

[ Alpha Fold Model ] (go)

Known binders annotated in ChEMBL

IC50 CSV

Only the first 20 rows are shown.

molecule_chembl_id	assay_type	relation	value	unit	mol_wt	smiles	organism	assay_chembl_id	bao_label
CHEMBL1089882	IC50	=	0.21	nM	522.57	Cn1cc(-c2cc3c(cn2)OC2(CCN(C(=O)c4ccc5[nH]c(-c6ccn(C)n6)nc5c4)CC2)CC3=O)cn1	Homo sapiens	CHEMBL1115284	cell-based format
CHEMBL1089883	IC50	=	0.3	nM	456.51	Cc1cc(C(=O)N2CCC3(CC2)CC(=O)c2cc(-c4cnn(C)c4)ncc2O3)cc2cn[nH]c12	Homo sapiens	CHEMBL1115284	cell-based format
CHEMBL1091996	IC50	=	0.31	nM	406.44	COc1cc2c(cn1)OC1(CCN(C(=O)c3cc(C)c4[nH]ncc4c3)CC1)CC2=O	Homo sapiens	CHEMBL1115284	cell-based format
CHEMBL3699916	IC50	=	1.0	nM	486.62	CC(C)(C)n1cc2c(n1)C(=O)NC1(CCN(C(=O)c3ccc4ccc(NC5CCC5)nc4c3)CC1)C2	Homo sapiens	CHEMBL3706246	cell-based format
CHEMBL2323626	IC50	=	1.3	nM	445.57	CNc1ccc2ccc(C(=O)N3CCC4(CC3)CC(=O)c3nn(C(C)(C)C)cc3C4)cc2n1	Homo sapiens	CHEMBL2329345	single protein format
CHEMBL3407547	IC50	=	1.7	nM	569.64	COc1ccccc1[C@H](Cn1c(=O)n(C(C)(C)C(=O)O)c(=O)c2c(C)c(-c3ncco3)sc21)OC1CCOCC1	Homo sapiens	CHEMBL3412274	single protein format
CHEMBL3699930	IC50	=	1.7	nM	510.59	CC(F)(F)CNc1ccc2ccc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)cc2n1	Homo sapiens	CHEMBL3706246	cell-based format
CHEMBL2419600	IC50	=	1.7	nM	474.61	CCCNc1ccc2ccc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)cc2n1	Homo sapiens	CHEMBL2422747	single protein format
CHEMBL3699929	IC50	=	1.72	nM	514.55	CC(C)(C)n1cc2c(n1)C(=O)NC1(CCN(C(=O)c3ccc4ccc(NCC(F)(F)F)nc4c3)CC1)C2	Homo sapiens	CHEMBL3706246	cell-based format
CHEMBL3699918	IC50	=	1.8	nM	460.58	CCNc1ccc2ccc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)cc2n1	Homo sapiens	CHEMBL3706246	cell-based format
CHEMBL4225405	IC50	=	1.9	nM	417.92	CCOc1nc2ccc(Oc3ccc(/C=C/[C@H](C)NC(C)=O)cn3)c(Cl)c2s1	Homo sapiens	CHEMBL4224643	single protein format
CHEMBL3699881	IC50	=	1.9	nM	449.56	COc1ccc(C)c2[nH]c(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)cc12	Homo sapiens	CHEMBL3706246	cell-based format
CHEMBL4229067	IC50	=	2.1	nM	399.49	CC(=O)N[C@@H](C)/C=C/c1ccc(Oc2ccc3nc(C(C)C)sc3c2F)nc1	Homo sapiens	CHEMBL4224643	single protein format
CHEMBL3699871	IC50	=	2.1	nM	436.56	CC1=CC(C(=O)N2CCC3(CC2)Cc2cn(C(C)(C)C)nc2C(=O)N3)=CC2C(C)=NNC12	Homo sapiens	CHEMBL3706246	cell-based format
CHEMBL2323628	IC50	=	2.1	nM	432.52	COc1ccc2ncc(C(=O)N3CCC4(CC3)CC(=O)c3c(cnn3C(C)C)C4)cc2c1	Homo sapiens	CHEMBL2329345	single protein format
CHEMBL3699903	IC50	=	2.1	nM	450.54	COc1cc(C(=O)N2CCC3(CC2)Cc2cn(C(C)(C)C)nc2C(=O)N3)cc2c(C)n[nH]c12	Homo sapiens	CHEMBL3706246	cell-based format
CHEMBL3699886	IC50	=	2.1	nM	454.96	Cc1cc(C(=O)N2CCC3(CC2)Cc2cn(C(C)(C)C)nc2C(=O)N3)cc2c(Cl)n[nH]c12	Homo sapiens	CHEMBL3706246	cell-based format
CHEMBL3699914	IC50	=	2.2	nM	474.61	CC(C)Nc1ccc2ccc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)cc2n1	Homo sapiens	CHEMBL3706246	cell-based format
CHEMBL2419589	IC50	=	2.3	nM	460.58	CN(C)c1ccc2ccc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)cc2n1	Homo sapiens	CHEMBL2422747	single protein format
CHEMBL3699893	IC50	=	2.4	nM	446.55	COc1cccc2ccc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)cc12	Homo sapiens	CHEMBL3706246	cell-based format

Pfam Domain Table

[ Domain: "ATP-grasp" // ATP-grasp ]

[ Domain: "CO dehydrogenase molybdoprotein N-domain-like" // Biotin_carb_C ]

[ Domain: "Single hybrid motif" // Biotin_lipoyl ]

[ Domain: "PreATP-grasp domain" // Biotin_carb_N ]

[ Domain: "ClpP/crotonase" // Carboxyl_trans_C ]