O00754 | MA2B1_HUMAN | Lysosomal alpha-mannosidase (MAN2B1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01074 | Glyco_hydro_38N - Glycosyl hydrolases family 38 N-terminal domain | 64~381 | |
| PF07748 | Glyco_hydro_38C - Glycosyl hydrolases family 38 C-terminal domain | 607~823 | |
| PF09261 | Alpha-mann_mid - Alpha mannosidase middle domain | 386~483 | |
| PF17677 | Glyco_hydro38C2 - Glycosyl hydrolases family 38 C-terminal beta sandwich domain | 900~1000 | |
| PF21260 | Laman-like_dom - Lysosomal alpha-mannosidase-like, central domain | 545~580 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL371197 |  |
IC50 | = | 50.0 | nM | 173.21 | O[C@H]1[C@H]2[C@H](O)CCCN2C[C@H]1O | Homo sapiens | CHEMBL987287 | cell-based format |
| CHEMBL476926 |  |
IC50 | = | 500.0 | nM | 280.32 | CN1C(=O)[C@H](O)[C@H](O)[C@H]1CN[C@@H](CO)c1ccccc1 | Homo sapiens | CHEMBL987286 | cell-based format |
| CHEMBL476343 |  |
IC50 | = | 750.0 | nM | 463.33 | CN1C(=O)[C@H](O)[C@H](O)[C@H]1CN[C@@H](COC(=O)c1ccc(Br)cc1)c1ccccc1 | Homo sapiens | CHEMBL987288 | single protein format |
| CHEMBL476926 | |
Ki | = | 550.0 | nM | 280.32 | CN1C(=O)[C@H](O)[C@H](O)[C@H]1CN[C@@H](CO)c1ccccc1 | Homo sapiens | CHEMBL987286 | cell-based format |