O00750 | P3C2B_HUMAN | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PIK3C2B)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00168 | C2 - C2 domain | 1518~1626 | |
| PF00454 | PI3_PI4_kinase - Phosphatidylinositol 3- and 4-kinase | 1078~1291 | |
| PF00613 | PI3Ka - Phosphoinositide 3-kinase family, accessory domain (PIK domain) | 812~988 | |
| PF00787 | PX - PX domain | 1395~1476 | |
| PF00792 | PI3K_C2 - Phosphoinositide 3-kinase C2 | 649~787 | |
| PF00794 | PI3K_rbd - PI3-kinase family, ras-binding domain | 365~465 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4869265 |  |
IC50 | = | 9.57 | nM | 481.62 | CN(C)C(=O)c1ccc2c(c1)c(C[C@H]1COCCN1c1nc3c(s1)C(=O)NC(C)(C)C3)cn2C | Homo sapiens | CHEMBL4807566 | single protein format |
| CHEMBL538346 |  |
IC50 | = | 10.0 | nM | 384.82 | Cl.Oc1cccc(-c2nc(N3CCOCC3)c3oc4ncccc4c3n2)c1 | Homo sapiens | CHEMBL906677 | cell-based format |
| CHEMBL1765602 |  |
IC50 | = | 24.5 | nM | 432.41 | Nc1ccc(-c2ccc3ncc4ccc(=O)n(-c5cccc(C(F)(F)F)c5)c4c3c2)cn1 | Homo sapiens | CHEMBL1768557 | single protein format |
| CHEMBL3913354 |  |
IC50 | = | 26.0 | nM | 347.37 | Oc1cccc(-c2cc3c(oc4ncccc43)c(N3CCOCC3)n2)c1 | Homo sapiens | CHEMBL3861261 | cell-based format |
| CHEMBL573339 |  |
IC50 | = | 26.0 | nM | 348.36 | Oc1cccc(-c2nc(N3CCOCC3)c3oc4ncccc4c3n2)c1 | Homo sapiens | CHEMBL3376670 | single protein format |
| CHEMBL2165017 |  |
IC50 | = | 29.0 | nM | 485.57 | COc1ccc(Nc2ncc(CN3CCN(S(C)(=O)=O)CC3)cc2-c2nc(C)nc(N)n2)cn1 | Homo sapiens | CHEMBL2169658 | single protein format |
| CHEMBL5405102 |  |
IC50 | = | 43.0 | nM | 487.48 | COc1c(OCc2cccc([N+](=O)[O-])c2)ccc2c1N=C(NC(=O)c1ccc(N)nc1)N1CCN=C21 | Homo sapiens | CHEMBL5373568 | cell-based format |
| CHEMBL1879463 |  |
IC50 | = | 44.0 | nM | 469.55 | Cn1c(=O)n(-c2ccc(C(C)(C)C#N)cc2)c2c3cc(-c4cnc5ccccc5c4)ccc3ncc21 | Homo sapiens | CHEMBL3861268 | single protein format |
| CHEMBL3354566 |  |
IC50 | = | 44.0 | nM | 467.53 | Cn1c(=O)n(-c2ccc(C3(C#N)CC3)cc2)c2c3cc(-c4cnc5ccccc5c4)ccc3ncc21 | Homo sapiens | CHEMBL3376670 | single protein format |
| CHEMBL1241857 |  |
IC50 | = | 64.0 | nM | 351.37 | COc1ccc2c(c1OC)N=C(NC(=O)c1cccnc1)N1CCN=C21 | Homo sapiens | CHEMBL3376670 | single protein format |
| CHEMBL541133 |  |
IC50 | = | 100.0 | nM | 471.35 | Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)c1nc(-c2cnc3ccc(Cl)cn23)cs1.Cl | Homo sapiens | CHEMBL919698 | single protein format |
| CHEMBL556399 |  |
IC50 | = | 100.0 | nM | 488.75 | Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)N(C)/N=C/c1cnc2ccc(Br)cn12.Cl | Homo sapiens | CHEMBL906677 | cell-based format |
| CHEMBL4749655 |  |
IC50 | = | 103.0 | nM | 454.53 | O=C(CCCCCCn1cnc2c(N3CCOCC3)nc(-c3cccc(CO)c3)nc21)NO | Homo sapiens | CHEMBL4707203 | single protein format |
| CHEMBL1229535 |  |
IC50 | = | 140.0 | nM | 389.89 | CC(=O)/N=c1/[nH]c(C)c(-c2ccc(Cl)c(S(=O)(=O)NCCO)c2)s1 | Homo sapiens | CHEMBL3376670 | single protein format |
| CHEMBL586702 |  |
IC50 | = | 180.0 | nM | 417.42 | FC(F)c1nc2ccccc2n1-c1nc(N2CCOCC2)nc(N2CCOCC2)n1 | Homo sapiens | CHEMBL3376670 | single protein format |
| CHEMBL541643 |  |
IC50 | = | 220.0 | nM | 349.84 | Cl.Oc1cccc(-c2nc(N3CCOCC3)c3sccc3n2)c1 | Homo sapiens | CHEMBL906677 | cell-based format |
| CHEMBL4164334 |  |
IC50 | = | 247.9 | nM | 494.04 | Cc1ccc(S(=O)(=O)Nc2cc(-c3sc(NC(=O)[C@@H](N)C(C)C)nc3C)cnc2Cl)cc1 | Homo sapiens | CHEMBL4156829 | assay format |
| CHEMBL2387080 |  |
IC50 | = | 292.0 | nM | 460.54 | Cc1nc(-c2cn3c(n2)-c2ccc(-c4cnn(C(C)(C)C(N)=O)c4)cc2OCC3)n(C(C)C)n1 | Homo sapiens | CHEMBL2388256 | single protein format |
| CHEMBL3922359 |  |
IC50 | = | 370.0 | nM | 434.9 | O=C1NC(=S)S/C1=C\c1ccc2c(c1)N(Cc1ccc(F)c(Cl)c1)C(=O)CO2 | Homo sapiens | CHEMBL3861261 | cell-based format |
| CHEMBL3218571 |  |
IC50 | = | 370.0 | nM | 434.9 | O=C1NC(=S)S/C1=C/c1ccc2c(c1)N(Cc1ccc(F)c(Cl)c1)C(=O)CO2 | Homo sapiens | CHEMBL3376670 | single protein format |