O00574 | CXCR6_HUMAN | C-X-C chemokine receptor type 6 (CXCR6)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 48~288 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4637126 |  |
IC50 | = | 40.0 | nM | 549.62 | COc1cc(C(=O)N[C@@H]2C[C@H]3CCC[C@@H](C2)N3Cc2nc3c(C(F)(F)F)cccc3s2)cc(OC)c1OC | Homo sapiens | CHEMBL4611266 | cell-based format |
| CHEMBL4638895 |  |
IC50 | = | 80.0 | nM | 560.51 | COc1cc(C(=O)N[C@@H]2C[C@H]3CCC[C@@H](C2)N3Cc2nc3c(Br)cccc3s2)cc(OC)c1OC | Homo sapiens | CHEMBL4611266 | cell-based format |
| CHEMBL4632425 |  |
IC50 | = | 110.0 | nM | 499.61 | COc1cc(C(=O)N[C@@H]2C[C@H]3CCC[C@@H](C2)N3Cc2nc3c(F)cccc3s2)cc(OC)c1OC | Homo sapiens | CHEMBL4611266 | cell-based format |
| CHEMBL4647701 |  |
IC50 | = | 120.0 | nM | 536.46 | COc1cc(C(=O)N[C@@H]2C[C@H]3CCC[C@@H](C2)N3CC(=O)Nc2cccc(Cl)c2Cl)cc(OC)c1OC | Homo sapiens | CHEMBL4611266 | cell-based format |
| CHEMBL4646569 |  |
IC50 | = | 130.0 | nM | 536.46 | COc1cc(C(=O)N[C@@H]2C[C@H]3CCC[C@@H](C2)N3CC(=O)Nc2cc(Cl)ccc2Cl)cc(OC)c1OC | Homo sapiens | CHEMBL4611266 | cell-based format |
| CHEMBL4646120 |  |
IC50 | = | 130.0 | nM | 516.06 | COc1cc(C(=O)N[C@@H]2C[C@H]3CCC[C@@H](C2)N3Cc2nc3c(Cl)cccc3s2)cc(OC)c1OC | Homo sapiens | CHEMBL4611266 | cell-based format |
| CHEMBL4645971 |  |
IC50 | = | 140.0 | nM | 502.01 | COc1cc(C(=O)N[C@@H]2C[C@H]3CCC[C@@H](C2)N3CC(=O)Nc2ccccc2Cl)cc(OC)c1OC | Homo sapiens | CHEMBL4611266 | cell-based format |
| CHEMBL4640388 |  |
IC50 | = | 160.0 | nM | 546.46 | COc1cc(C(=O)N[C@@H]2C[C@H]3CCC[C@@H](C2)N3CC(=O)Nc2ccccc2Br)cc(OC)c1OC | Homo sapiens | CHEMBL4611266 | cell-based format |
| CHEMBL4648997 |  |
IC50 | = | 160.0 | nM | 536.46 | COc1cc(C(=O)N[C@@H]2C[C@H]3CCC[C@@H](C2)N3CC(=O)Nc2ccc(Cl)cc2Cl)cc(OC)c1OC | Homo sapiens | CHEMBL4611266 | cell-based format |
| CHEMBL4641681 |  |
IC50 | = | 170.0 | nM | 516.06 | COc1cc(C(=O)N[C@@H]2C[C@H]3CCC[C@@H](C2)N3Cc2nc3cc(Cl)ccc3s2)cc(OC)c1OC | Homo sapiens | CHEMBL4611266 | cell-based format |
| CHEMBL4639692 |  |
IC50 | = | 250.0 | nM | 495.65 | COc1cc(C(=O)N[C@@H]2C[C@H]3CCC[C@@H](C2)N3Cc2nc3c(C)cccc3s2)cc(OC)c1OC | Homo sapiens | CHEMBL4611266 | cell-based format |
| CHEMBL4638493 |  |
IC50 | = | 260.0 | nM | 516.06 | COc1cc(C(=O)N[C@@H]2C[C@H]3CCC[C@@H](C2)N3Cc2nc3cccc(Cl)c3s2)cc(OC)c1OC | Homo sapiens | CHEMBL4611266 | cell-based format |
| CHEMBL4640319 |  |
IC50 | = | 270.0 | nM | 516.06 | COc1cc(C(=O)N[C@@H]2C[C@H]3CCC[C@@H](C2)N3Cc2nc3ccc(Cl)cc3s2)cc(OC)c1OC | Homo sapiens | CHEMBL4611266 | cell-based format |
| CHEMBL4642230 |  |
IC50 | = | 300.0 | nM | 481.62 | COc1cc(C(=O)N[C@@H]2C[C@H]3CCC[C@@H](C2)N3Cc2nc3ccccc3s2)cc(OC)c1OC | Homo sapiens | CHEMBL4611266 | cell-based format |
| CHEMBL4647206 |  |
IC50 | = | 310.0 | nM | 536.46 | COc1cc(C(=O)N[C@@H]2C[C@H]3CCC[C@@H](C2)N3CC(=O)Nc2cc(Cl)cc(Cl)c2)cc(OC)c1OC | Homo sapiens | CHEMBL4611266 | cell-based format |
| CHEMBL4649351 |  |
IC50 | = | 350.0 | nM | 536.46 | COc1cc(C(=O)N[C@@H]2C[C@H]3CCC[C@@H](C2)N3CC(=O)Nc2ccc(Cl)c(Cl)c2)cc(OC)c1OC | Homo sapiens | CHEMBL4611266 | cell-based format |
| CHEMBL4645763 |  |
IC50 | = | 350.0 | nM | 546.46 | COc1cc(C(=O)N[C@@H]2C[C@H]3CCC[C@@H](C2)N3CC(=O)Nc2cccc(Br)c2)cc(OC)c1OC | Homo sapiens | CHEMBL4611266 | cell-based format |
| CHEMBL4635707 |  |
IC50 | = | 410.0 | nM | 502.01 | COc1cc(C(=O)N[C@@H]2C[C@H]3CCC[C@@H](C2)N3CC(=O)Nc2cccc(Cl)c2)cc(OC)c1OC | Homo sapiens | CHEMBL4611266 | cell-based format |
| CHEMBL4639114 |  |
IC50 | = | 610.0 | nM | 495.62 | COc1cc(C(=O)N[C@@H]2C[C@H]3CCC[C@@H](C2)N3CC(=O)Nc2cc(C)ccc2C)cc(OC)c1OC | Homo sapiens | CHEMBL4611266 | cell-based format |
| CHEMBL4644133 |  |
IC50 | = | 620.0 | nM | 485.56 | COc1cc(C(=O)N[C@@H]2C[C@H]3CCC[C@@H](C2)N3CC(=O)Nc2ccccc2F)cc(OC)c1OC | Homo sapiens | CHEMBL4611266 | cell-based format |