O00571 | DDX3X_HUMAN | ATP-dependent RNA helicase DDX3X (DDX3X)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00270 | DEAD - DEAD/DEAH box helicase | 204~391 | |
| PF00271 | Helicase_C - Helicase conserved C-terminal domain | 427~536 |
3D structures mapped by conservation among orthologs
[ Domain: "P-loop containing nucleoside triphosphate hydrolases" // DEAD ]
[ Domain: "P-loop containing nucleoside triphosphate hydrolases" // Helicase_C ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4633761 |  |
IC50 | = | 5.0 | nM | 430.49 | CCOCc1cn(-c2cccc(S(=O)(=O)Nc3cccc(C(=O)OCC)c3)c2)nn1 | Homo sapiens | CHEMBL4616148 | assay format |
| CHEMBL4633565 |  |
IC50 | = | 60.0 | nM | 428.52 | CCCCc1cn(-c2ccc(NC(=O)Nc3ccccc3NS(C)(=O)=O)cc2)nn1 | Homo sapiens | CHEMBL4616148 | assay format |
| CHEMBL4642739 |  |
IC50 | = | 60.0 | nM | 443.53 | CCOCc1cn(-c2cccc(S(=O)(=O)Nc3ccccc3N3CCOCC3)c2)nn1 | Homo sapiens | CHEMBL4616148 | assay format |
| CHEMBL5220761 |  |
IC50 | = | 70.0 | nM | 403.41 | CCCCc1nc(-c2ccc(NC(=O)Nc3ccccc3C(F)(F)F)cc2)n[nH]1 | Homo sapiens | CHEMBL5216453 | single protein format |
| CHEMBL4644016 |  |
IC50 | = | 80.0 | nM | 451.53 | CCOCc1cn(-c2cccc(S(=O)(=O)Nc3ccccc3NS(C)(=O)=O)c2)nn1 | Homo sapiens | CHEMBL4616148 | assay format |
| CHEMBL4792698 |  |
IC50 | = | 100.0 | nM | 435.53 | CCCCc1cn(-c2ccc(NC(=O)Nc3cc(OC4CCOC4)ccc3C)cc2)nn1 | Homo sapiens | CHEMBL4687213 | single protein format |
| CHEMBL5220068 |  |
IC50 | = | 120.0 | nM | 353.4 | CC(C)Cc1cn(-c2ccc(NC(=O)Nc3ccccc3F)cc2)nn1 | Homo sapiens | CHEMBL5216452 | single protein format |
| CHEMBL4591917 |  |
IC50 | = | 120.0 | nM | 407.5 | CCCCc1cn(-c2cccc(S(=O)(=O)Nc3cccc4cnccc34)c2)nn1 | Homo sapiens | CHEMBL4616148 | assay format |
| CHEMBL4764675 |  |
IC50 | = | 120.0 | nM | 400.49 | CC(C)CCc1cn(-c2ccc(NC(=O)Nc3cccc4cnccc34)cc2)nn1 | Homo sapiens | CHEMBL4687213 | single protein format |
| CHEMBL4634423 |  |
IC50 | = | 120.0 | nM | 367.43 | CC(C)CCc1cn(-c2ccc(NC(=O)Nc3ccccc3F)cc2)nn1 | Homo sapiens | CHEMBL4616148 | assay format |
| CHEMBL5220029 |  |
IC50 | = | 140.0 | nM | 419.53 | CCCCc1cn(-c2ccc(NC(=O)Nc3ccccc3OC3CCCC3)cc2)nn1 | Homo sapiens | CHEMBL5216452 | single protein format |
| CHEMBL4743218 |  |
IC50 | = | 140.0 | nM | 433.56 | CCCCc1cn(-c2ccc(NC(=O)Nc3cc(OC4CCCC4)ccc3C)cc2)nn1 | Homo sapiens | CHEMBL4687213 | single protein format |
| CHEMBL4744776 |  |
IC50 | = | 150.0 | nM | 386.46 | CCCCc1cn(-c2ccc(NC(=O)Nc3cccc4cnccc34)cc2)nn1 | Homo sapiens | CHEMBL4687213 | single protein format |
| CHEMBL5218961 |  |
IC50 | = | 150.0 | nM | 386.46 | CC(C)Cc1cn(-c2ccc(NC(=O)Nc3ccc4cnccc4c3)cc2)nn1 | Homo sapiens | CHEMBL5216452 | single protein format |
| CHEMBL4639795 |  |
IC50 | = | 170.0 | nM | 363.47 | Cc1ccccc1NC(=O)Nc1ccc(-n2cc(CCC(C)C)nn2)cc1 | Homo sapiens | CHEMBL4616148 | assay format |
| CHEMBL4577525 |  |
IC50 | = | 180.0 | nM | 386.48 | CCCCc1cn(-c2cccc(S(=O)(=O)Nc3ccccc3OC)c2)nn1 | Homo sapiens | CHEMBL4616148 | assay format |
| CHEMBL5220798 |  |
IC50 | = | 200.0 | nM | 353.4 | CC(C)Cc1cn(-c2ccc(NC(=O)Nc3cccc(F)c3)cc2)nn1 | Homo sapiens | CHEMBL5216452 | single protein format |
| CHEMBL5219645 |  |
IC50 | = | 200.0 | nM | 269.26 | O=C(O)c1cc(Nc2nc3ccccc3[nH]2)ccc1O | Homo sapiens | CHEMBL5216454 | single protein format |
| CHEMBL4648145 |  |
IC50 | = | 200.0 | nM | 367.43 | CC(C)CCc1cn(-c2ccc(NC(=O)Nc3cccc(F)c3)cc2)nn1 | Homo sapiens | CHEMBL4616148 | assay format |
| CHEMBL4635666 |  |
IC50 | = | 300.0 | nM | 431.46 | CCCCCCc1cn(-c2ccc(NC(=O)Nc3ccccc3C(F)(F)F)cc2)nn1 | Homo sapiens | CHEMBL4616148 | assay format |