O00519 | FAAH1_HUMAN | Fatty-acid amide hydrolase 1 (FAAH)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01425 | Amidase - Amidase | 96~562 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3797772 |  |
IC50 | = | 0.01 | nM | 468.97 | O=C(Oc1ccc(Cl)cc1)N1CCN(c2nc(C3=NOC(c4ccccc4)C3)cs2)CC1 | Homo sapiens | CHEMBL3802167 | assay format |
| CHEMBL3798535 |  |
IC50 | = | 0.01 | nM | 463.56 | COc1ccc(OC(=O)N2CCC(c3nc(C4=NOC(c5ccccc5)C4)cs3)CC2)cc1 | Homo sapiens | CHEMBL3802167 | assay format |
| CHEMBL3798487 |  |
IC50 | = | 0.02 | nM | 434.52 | O=C(Oc1cccnc1)N1CCC(c2nc(C3=NOC(c4ccccc4)C3)cs2)CC1 | Homo sapiens | CHEMBL3802167 | assay format |
| CHEMBL3797635 |  |
IC50 | = | 0.03 | nM | 458.54 | N#Cc1cccc(OC(=O)N2CCC(c3nc(C4=NOC(c5ccccc5)C4)cs3)CC2)c1 | Homo sapiens | CHEMBL3802167 | assay format |
| CHEMBL3800456 |  |
IC50 | = | 0.04 | nM | 447.56 | Cc1ccccc1OC(=O)N1CCC(c2nc(C3=NOC(c4ccccc4)C3)cs2)CC1 | Homo sapiens | CHEMBL3802167 | assay format |
| CHEMBL3797841 |  |
IC50 | = | 0.06 | nM | 467.98 | O=C(Oc1ccccc1Cl)N1CCC(c2nc(C3=NOC(c4ccccc4)C3)cs2)CC1 | Homo sapiens | CHEMBL3802167 | assay format |
| CHEMBL3798156 |  |
IC50 | = | 0.07 | nM | 433.53 | O=C(Oc1ccccc1)N1CCC(c2nc(C3=NOC(c4ccccc4)C3)cs2)CC1 | Homo sapiens | CHEMBL3802167 | assay format |
| CHEMBL3799744 |  |
IC50 | = | 0.08 | nM | 467.98 | O=C(Oc1ccc(Cl)cc1)N1CCC(c2nc(C3=NOC(c4ccccc4)C3)cs2)CC1 | Homo sapiens | CHEMBL3802167 | assay format |
| CHEMBL3797809 |  |
IC50 | = | 0.09 | nM | 459.53 | N#Cc1ccc(OC(=O)N2CCN(c3nc(C4=NOC(c5ccccc5)C4)cs3)CC2)cc1 | Homo sapiens | CHEMBL3802167 | assay format |
| CHEMBL1812722 |  |
IC50 | = | 0.093 | nM | 395.43 | O=C(N1CCC(Oc2ccc(OCc3cccc(F)c3)cc2)CC1)n1ccnc1 | Homo sapiens | CHEMBL1816096 | single protein format |
| CHEMBL182199 |  |
IC50 | = | 0.1 | nM | 336.44 | O=C(CCCCCCCCc1ccccc1)c1nc2ncccc2o1 | Homo sapiens | CHEMBL833470 | single protein format |
| CHEMBL112486 |  |
IC50 | = | 0.1 | nM | 356.55 | CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCCS(=O)(=O)F | Homo sapiens | CHEMBL832951 | single protein format |
| CHEMBL3798476 |  |
IC50 | = | 0.14 | nM | 458.54 | N#Cc1ccc(OC(=O)N2CCC(c3nc(C4=NOC(c5ccccc5)C4)cs3)CC2)cc1 | Homo sapiens | CHEMBL3802167 | assay format |
| CHEMBL598764 |  |
IC50 | = | 0.15 | nM | 411.55 | CCCCCCCCCCCOc1ccc(NC(=O)O/N=C/c2cccnc2)cc1 | Homo sapiens | CHEMBL1068137 | cell-based format |
| CHEMBL3798355 |  |
IC50 | = | 0.16 | nM | 502.52 | O=C(Oc1ccc(C(F)(F)F)cc1)N1CCN(c2nc(C3=NOC(c4ccccc4)C3)cs2)CC1 | Homo sapiens | CHEMBL3802167 | assay format |
| CHEMBL4078217 |  |
IC50 | = | 0.16 | nM | 407.31 | O=C(OC(C(F)(F)F)C(F)(F)F)N1CC(c2ccn(Cc3ccccc3)n2)C1 | Homo sapiens | CHEMBL4032632 | single protein format |
| CHEMBL3799008 |  |
IC50 | = | 0.2 | nM | 459.53 | N#Cc1cccc(OC(=O)N2CCN(c3nc(C4=NOC(c5ccccc5)C4)cs3)CC2)c1 | Homo sapiens | CHEMBL3802167 | assay format |
| CHEMBL597648 |  |
IC50 | = | 0.2 | nM | 400.49 | CCCCCCCCCOc1ccc(NC(=O)O/N=C/c2ccc(F)cc2)cc1 | Homo sapiens | CHEMBL1068137 | cell-based format |
| CHEMBL3799516 |  |
IC50 | = | 0.2 | nM | 479.52 | O=C(Oc1ccc([N+](=O)[O-])cc1)N1CCN(c2nc(C3=NOC(c4ccccc4)C3)cs2)CC1 | Homo sapiens | CHEMBL3802167 | assay format |
| CHEMBL3800599 |  |
IC50 | = | 0.2 | nM | 447.56 | Cc1ccc(OC(=O)N2CCC(c3nc(C4=NOC(c5ccccc5)C4)cs3)CC2)cc1 | Homo sapiens | CHEMBL3802167 | assay format |