O00506 | STK25_HUMAN | Serine/threonine-protein kinase 25 (STK25)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 21~270 | |
| PF20929 | PDCD10_N - Programmed cell death protein 10, dimerisation domain | 357~411 |
3D structures mapped by conservation among orthologs
[ Domain: "CCM3/GCKIII dimerization domain" // DUF1241_N ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL388978 |  |
IC50 | = | 2.71 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328616 | single protein format |
| CHEMBL3943675 |  |
IC50 | = | 12.0 | nM | 486.58 | Cc1ccc(C(=O)Nc2cc(C(C)(C)C)n[nH]2)cc1-n1cc(-c2cncc(N3CCOCC3)c2)nn1 | Homo sapiens | CHEMBL5224588 | single protein format |
| CHEMBL3770443 |  |
IC50 | = | 34.0 | nM | 492.97 | CNc1ncc2cc(-c3ccc(-c4cccc(C)n4)cc3Cl)c(=O)n(C[C@H]3OC[C@H](N)CO3)c2n1 | Homo sapiens | CHEMBL3772534 | single protein format |
| CHEMBL5276146 |  |
IC50 | = | 228.0 | nM | 376.48 | CC(C)(C)c1cc(NC(=O)c2ccc(S(=O)(=O)N3CCCC3)cc2)n[nH]1 | Homo sapiens | CHEMBL5224589 | single protein format |
| CHEMBL495727 |  |
IC50 | = | 460.0 | nM | 381.44 | O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 | Homo sapiens | CHEMBL5224588 | single protein format |
| CHEMBL5278528 |  |
IC50 | = | 616.0 | nM | 315.42 | CCCCOc1ccc(C(=O)Nc2cc(C(C)(C)C)[nH]n2)cc1 | Homo sapiens | CHEMBL5224589 | single protein format |
| CHEMBL5286173 |  |
IC50 | = | 865.0 | nM | 390.51 | CC(C)(C)c1cc(NC(=O)c2ccc(S(=O)(=O)NC3CCCC3)cc2)n[nH]1 | Homo sapiens | CHEMBL5224589 | single protein format |