O00487 | PSDE_HUMAN | 26S proteasome non-ATPase regulatory subunit 14 (PSMD14)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01398 | JAB - JAB1/Mov34/MPN/PAD-1 ubiquitin protease | 27~138 | |
| PF23594 | RPN11_C - 26S proteasome regulatory subunit RPN11 C-terminal domain | 228~307 |
3D structures mapped by conservation among orthologs
[ Domain: "Cytidine deaminase-like" // JAB ]
[ Domain: "26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain" // EUF08560 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4104719 |  |
IC50 | = | 200.0 | nM | 588.72 | O=C(NCc1ccncc1)c1cnc2c(SSc3cccc4cc(C(=O)NCc5ccncc5)cnc34)cccc2c1 | Homo sapiens | CHEMBL4049704 | cell-based format |
| CHEMBL4070821 |  |
IC50 | = | 400.0 | nM | 572.72 | O=C(Nc1nccs1)c1cnc2c(SSc3cccc4cc(C(=O)Nc5nccs5)cnc34)cccc2c1 | Homo sapiens | CHEMBL4049704 | cell-based format |
| CHEMBL4105598 |  |
IC50 | = | 800.0 | nM | 598.8 | O=C(NCc1cccs1)c1cnc2c(SSc3cccc4cc(C(=O)NCc5cccs5)cnc34)cccc2c1 | Homo sapiens | CHEMBL4049704 | cell-based format |
| CHEMBL4095913 |  |
IC50 | = | 900.0 | nM | 566.66 | O=C(NCc1ccco1)c1cnc2c(SSc3cccc4cc(C(=O)NCc5ccco5)cnc34)cccc2c1 | Homo sapiens | CHEMBL4049704 | cell-based format |
| CHEMBL4093473 |  |
IC50 | = | 900.0 | nM | 436.51 | COC(=O)c1cnc2c(SSc3cccc4cc(C(=O)OC)cnc34)cccc2c1 | Homo sapiens | CHEMBL4049704 | cell-based format |
| CHEMBL4101230 |  |
IC50 | = | 900.0 | nM | 175.26 | Cc1cc(S)c2ncccc2c1 | Homo sapiens | CHEMBL4049704 | cell-based format |
| CHEMBL4078891 |  |
IC50 | = | 1000.0 | nM | 406.49 | NC(=O)c1cnc2c(SSc3cccc4cc(C(N)=O)cnc34)cccc2c1 | Homo sapiens | CHEMBL4049704 | cell-based format |
| CHEMBL4087722 |  |
IC50 | = | 1000.0 | nM | 598.8 | O=C(NCc1cccs1)c1ccnc2c(SSc3cccc4c(C(=O)NCc5cccs5)ccnc34)cccc12 | Homo sapiens | CHEMBL4049704 | cell-based format |
| CHEMBL4077883 |  |
IC50 | = | 1000.0 | nM | 436.51 | COC(=O)c1ccnc2c(SSc3cccc4c(C(=O)OC)ccnc34)cccc12 | Homo sapiens | CHEMBL4049704 | cell-based format |
| CHEMBL4091693 |  |
IC50 | = | 1000.0 | nM | 574.73 | O=C(NCC1CCCO1)c1cnc2c(SSc3cccc4cc(C(=O)NCC5CCCO5)cnc34)cccc2c1 | Homo sapiens | CHEMBL4049702 | cell-based format |