O00444 | PLK4_HUMAN | Serine/threonine-protein kinase PLK4 (PLK4)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 13~265 | |
| PF18190 | Plk4_PB1 - Polo-like Kinase 4 Polo Box 1 | 592~697 | |
| PF18409 | Plk4_PB2 - Polo-like Kinase 4 Polo Box 2 | 699~807 |
3D structures mapped by conservation among orthologs
[ Domain: "Polo-box domain" // POLO_box_Plk4_1 ]
[ Domain: "Polo-box domain" // POLO_box_Plk4_2 ]
[ Domain: "Polo-box domain" // POLO_box_3 ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5209160 |  |
IC50 | = | 0.1 | nM | 356.34 | Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3[nH]ncc23)n[nH]1 | Homo sapiens | CHEMBL5115458 | single protein format |
| CHEMBL5185001 |  |
IC50 | = | 0.2 | nM | 440.46 | Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3c2cnn3C2CCOCC2)n[nH]1 | Homo sapiens | CHEMBL5115458 | single protein format |
| CHEMBL5404983 |  |
IC50 | = | 0.3 | nM | 509.91 | Cc1cc(Nc2nc(NCc3ccc(Cl)c(C(=O)Nc4cc(F)ccc4F)c3)nc3[nH]ncc23)n[nH]1 | Homo sapiens | CHEMBL5381874 | single protein format |
| CHEMBL5171469 |  |
IC50 | = | 0.3 | nM | 354.81 | Cc1cc(Nc2nc(NCc3ccc(Cl)cc3)nc3[nH]ncc23)n[nH]1 | Homo sapiens | CHEMBL5115458 | single protein format |
| CHEMBL2407898 |  |
IC50 | = | 0.32 | nM | 450.54 | COc1ccc2c(c1)/C(=C\c1ccc3c(/C=C/c4ccc(CN(C)C)cc4)n[nH]c3c1)C(=O)N2 | Homo sapiens | CHEMBL2410318 | assay format |
| CHEMBL3408955 |  |
IC50 | = | 0.39 | nM | 547.7 | COc1ccc2c(c1)[C@]1(C[C@H]1c1ccc3c(/C=C/c4ccc(CN5[C@H](C)CN(C)C[C@@H]5C)cc4)n[nH]c3c1)C(=O)N2 | Homo sapiens | CHEMBL3411381 | single protein format |
| CHEMBL4553351 |  |
IC50 | = | 0.45 | nM | 465.56 | COc1ccc2c(c1)[C@]1(C[C@H]1c1ccc3c(-c4ccc(N5CCNCC5)cc4)n[nH]c3c1)C(=O)N2 | Homo sapiens | CHEMBL4430364 | single protein format |
| CHEMBL2407894 |  |
IC50 | = | 0.45 | nM | 394.43 | COc1ccc2c(c1)/C(=C\c1ccc3c(/C=C/c4ccncc4)n[nH]c3c1)C(=O)N2 | Homo sapiens | CHEMBL2410318 | assay format |
| CHEMBL2407748 |  |
IC50 | = | 0.48 | nM | 394.43 | COc1ccc2c(c1)/C(=C\c1ccc3c(/C=C/c4cccnc4)n[nH]c3c1)C(=O)N2 | Homo sapiens | CHEMBL2410318 | assay format |
| CHEMBL3408944 |  |
IC50 | = | 0.6 | nM | 504.63 | COc1ccc2c(c1)[C@]1(C[C@H]1c1ccc3c(/C=C/c4ccc(CN5CCCCC5)cc4)n[nH]c3c1)C(=O)N2 | Homo sapiens | CHEMBL3411381 | single protein format |
| CHEMBL2407900 |  |
IC50 | = | 0.61 | nM | 492.58 | COc1ccc2c(c1)/C(=C\c1ccc3c(/C=C/c4ccc(N5CCN(C)CC5)nc4)n[nH]c3c1)C(=O)N2 | Homo sapiens | CHEMBL2410318 | assay format |
| CHEMBL3408954 |  |
IC50 | = | 0.64 | nM | 517.68 | C[C@@H]1CN(Cc2ccc(/C=C/c3n[nH]c4cc([C@@H]5C[C@@]56C(=O)Nc5ccccc56)ccc34)cc2)C[C@H](C)N1C | Homo sapiens | CHEMBL3411381 | single protein format |
| CHEMBL5171233 |  |
IC50 | = | 0.7 | nM | 354.81 | Cc1cc(Nc2nc(NCc3ccccc3Cl)nc3[nH]ncc23)n[nH]1 | Homo sapiens | CHEMBL5115458 | single protein format |
| CHEMBL5188129 |  |
IC50 | = | 0.7 | nM | 439.47 | Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3c2cnn3C2CCNCC2)n[nH]1 | Homo sapiens | CHEMBL5115458 | single protein format |
| CHEMBL5183346 |  |
IC50 | = | 0.7 | nM | 454.49 | CCc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3c2cnn3C2CCOCC2)n[nH]1 | Homo sapiens | CHEMBL5115458 | single protein format |
| CHEMBL3353351 |  |
IC50 | = | 0.71 | nM | 448.57 | Cc1ccc2c(c1)[C@]1(C[C@H]1c1ccc3c(/C=C/c4ccc(CN(C)C)cc4)n[nH]c3c1)C(=O)N2 | Homo sapiens | CHEMBL3364610 | assay format |
| CHEMBL3353352 |  |
IC50 | = | 0.79 | nM | 452.53 | CN(C)Cc1ccc(/C=C/c2n[nH]c3cc([C@@H]4C[C@@]45C(=O)Nc4ccc(F)cc45)ccc23)cc1 | Homo sapiens | CHEMBL3364610 | assay format |
| CHEMBL5200865 |  |
IC50 | = | 0.8 | nM | 338.35 | Cc1cc(Nc2nc(NCc3ccc(F)cc3)nc3[nH]ncc23)n[nH]1 | Homo sapiens | CHEMBL5115458 | single protein format |
| CHEMBL2407744 |  |
IC50 | = | 0.82 | nM | 407.43 | O=C1Nc2ccccc2/C1=C\c1ccc2c(/C=C/c3ccc(C(=O)O)cc3)n[nH]c2c1 | Homo sapiens | CHEMBL2410318 | assay format |
| CHEMBL3408941 |  |
IC50 | = | 0.9 | nM | 461.57 | O=C1Nc2ccccc2[C@]12C[C@H]2c1ccc2c(/C=C/c3ccc(N4CCNCC4)cc3)n[nH]c2c1 | Homo sapiens | CHEMBL3411381 | single protein format |