O00443 | P3C2A_HUMAN | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PIK3C2A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00168 | C2 - C2 domain | 1572~1680 | |
| PF00454 | PI3_PI4_kinase - Phosphatidylinositol 3- and 4-kinase | 1133~1346 | |
| PF00613 | PI3Ka - Phosphoinositide 3-kinase family, accessory domain (PIK domain) | 868~1041 | |
| PF00787 | PX - PX domain | 1455~1533 | |
| PF00792 | PI3K_C2 - Phosphoinositide 3-kinase C2 | 703~840 | |
| PF00794 | PI3K_rbd - PI3-kinase family, ras-binding domain | 412~511 |
3D structures mapped by conservation among orthologs
[ Domain: "C2 domain" // C2_2 ]
[ Domain: "PX domain" // PX ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5405102 |  |
IC50 | = | 7.0 | nM | 487.48 | COc1c(OCc2cccc([N+](=O)[O-])c2)ccc2c1N=C(NC(=O)c1ccc(N)nc1)N1CCN=C21 | Homo sapiens | CHEMBL5373567 | cell-based format |
| CHEMBL4869265 |  |
IC50 | = | 9.57 | nM | 481.62 | CN(C)C(=O)c1ccc2c(c1)c(C[C@H]1COCCN1c1nc3c(s1)C(=O)NC(C)(C)C3)cn2C | Homo sapiens | CHEMBL4807555 | single protein format |
| CHEMBL5423317 |  |
IC50 | = | 13.0 | nM | 366.38 | COc1ccc2c(c1OC)N=C(NC(=O)c1ccc(N)nc1)N1CCN=C21 | Homo sapiens | CHEMBL5373567 | cell-based format |
| CHEMBL1765602 |  |
IC50 | = | 28.1 | nM | 432.41 | Nc1ccc(-c2ccc3ncc4ccc(=O)n(-c5cccc(C(F)(F)F)c5)c4c3c2)cn1 | Homo sapiens | CHEMBL1768558 | single protein format |
| CHEMBL3354566 |  |
IC50 | = | 34.0 | nM | 467.53 | Cn1c(=O)n(-c2ccc(C3(C#N)CC3)cc2)c2c3cc(-c4cnc5ccccc5c4)ccc3ncc21 | Homo sapiens | CHEMBL3376669 | single protein format |
| CHEMBL1879463 |  |
IC50 | = | 34.0 | nM | 469.55 | Cn1c(=O)n(-c2ccc(C(C)(C)C#N)cc2)c2c3cc(-c4cnc5ccccc5c4)ccc3ncc21 | Homo sapiens | CHEMBL3861267 | single protein format |
| CHEMBL1241857 |  |
IC50 | = | 47.0 | nM | 351.37 | COc1ccc2c(c1OC)N=C(NC(=O)c1cccnc1)N1CCN=C21 | Homo sapiens | CHEMBL3376669 | single protein format |
| CHEMBL5438439 |  |
IC50 | = | 47.0 | nM | 593.72 | CS(=O)(=O)Nc1cccc(-c2csc(NC(=O)CSc3nc4nccnc4c(=O)n3CCc3ccccc3)n2)c1 | Homo sapiens | CHEMBL5373584 | single protein format |
| CHEMBL5421268 |  |
IC50 | = | 56.0 | nM | 599.74 | CC(C)(NC(=O)Cc1csc(NC(=O)CSc2nc3nccnc3c(=O)n2CCc2ccccc2)n1)c1ccccc1 | Homo sapiens | CHEMBL5373584 | single protein format |
| CHEMBL5439621 |  |
IC50 | = | 73.0 | nM | 571.69 | O=C(Cc1csc(NC(=O)CSc2nc3nccnc3c(=O)n2CCc2ccccc2)n1)NCc1ccccc1 | Homo sapiens | CHEMBL5373584 | single protein format |
| CHEMBL5435824 |  |
IC50 | = | 87.0 | nM | 597.73 | O=C(CSc1nc2nccnc2c(=O)n1CCc1ccccc1)Nc1nc(CC(=O)N2CCc3ccccc3C2)cs1 | Homo sapiens | CHEMBL5373584 | single protein format |
| CHEMBL5408600 |  |
IC50 | = | 94.0 | nM | 577.72 | O=C(Cc1csc(NC(=O)CSc2nc3nccnc3c(=O)n2CCc2ccccc2)n1)NCc1cccs1 | Homo sapiens | CHEMBL5373584 | single protein format |
| CHEMBL5438942 |  |
IC50 | = | 100.0 | nM | 557.66 | O=C(Cc1csc(NC(=O)CSc2nc3nccnc3c(=O)n2CCc2ccccc2)n1)Nc1ccccc1 | Homo sapiens | CHEMBL5373584 | single protein format |
| CHEMBL5400057 |  |
IC50 | = | 100.0 | nM | 424.51 | O=C(CSc1nc2nccnc2c(=O)n1CCc1ccccc1)Nc1nccs1 | Homo sapiens | CHEMBL5373584 | single protein format |
| CHEMBL5428216 |  |
IC50 | = | 100.0 | nM | 597.73 | O=C(CSc1nc2nccnc2c(=O)n1CCc1ccccc1)Nc1nc(CC(=O)NC2(c3ccccc3)CC2)cs1 | Homo sapiens | CHEMBL5373584 | single protein format |
| CHEMBL5394962 |  |
IC50 | = | 119.0 | nM | 585.72 | O=C(Cc1csc(NC(=O)CSc2nc3nccnc3c(=O)n2CCc2ccccc2)n1)NCCc1ccccc1 | Homo sapiens | CHEMBL5373584 | single protein format |
| CHEMBL5423664 |  |
IC50 | = | 138.0 | nM | 572.68 | O=C(Cc1csc(NC(=O)CSc2nc3nccnc3c(=O)n2CCc2ccccc2)n1)NCc1ccncc1 | Homo sapiens | CHEMBL5373584 | single protein format |
| CHEMBL3218571 |  |
IC50 | = | 140.0 | nM | 434.9 | O=C1NC(=S)S/C1=C/c1ccc2c(c1)N(Cc1ccc(F)c(Cl)c1)C(=O)CO2 | Homo sapiens | CHEMBL3376669 | single protein format |
| CHEMBL3922359 |  |
IC50 | = | 140.0 | nM | 434.9 | O=C1NC(=S)S/C1=C\c1ccc2c(c1)N(Cc1ccc(F)c(Cl)c1)C(=O)CO2 | Homo sapiens | CHEMBL3861260 | cell-based format |
| CHEMBL5440247 |  |
IC50 | = | 150.0 | nM | 515.62 | Nc1cccc(-c2csc(NC(=O)CSc3nc4nccnc4c(=O)n3CCc3ccccc3)n2)c1 | Homo sapiens | CHEMBL5373584 | single protein format |