O00421 | CCRL2_HUMAN | C-C chemokine receptor-like 2 (CCRL2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 56~300 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3704025 |  |
IC50 | = | 4.0 | nM | 500.53 | O=C(CNc1ncnc2ccc(C(F)(F)F)cc12)NC1CN(C2CCC(c3ncccc3O)CC2)C1 | Homo sapiens | CHEMBL3706360 | cell-based format |
| CHEMBL3704083 |  |
IC50 | = | 5.0 | nM | 484.53 | O=C(CNc1ncnc2ccc(C(F)(F)F)cc12)NC1CN(C2CCC(c3ccccn3)CC2)C1 | Homo sapiens | CHEMBL3706360 | cell-based format |
| CHEMBL3704026 |  |
IC50 | = | 5.0 | nM | 489.54 | O=C(CNc1ncnc2ccc(C(F)(F)F)cc12)NC1CN([C@H]2CC[C@@H](C3CC=CCO3)CC2)C1 | Homo sapiens | CHEMBL3706360 | cell-based format |
| CHEMBL3704082 |  |
IC50 | = | 5.0 | nM | 484.53 | O=C(CNc1ncnc2ccc(C(F)(F)F)cc12)NC1CN(C2CCC(c3cccnc3)CC2)C1 | Homo sapiens | CHEMBL3706360 | cell-based format |
| CHEMBL3704085 |  |
IC50 | = | 6.0 | nM | 514.55 | COc1cnccc1C1CCC(N2CC(NC(=O)CNc3ncnc4ccc(C(F)(F)F)cc34)C2)CC1 | Homo sapiens | CHEMBL3706360 | cell-based format |
| CHEMBL3704084 |  |
IC50 | = | 6.0 | nM | 500.53 | O=C(CNc1ncnc2ccc(C(F)(F)F)cc12)NC1CN(C2CCC(c3ccc(O)cn3)CC2)C1 | Homo sapiens | CHEMBL3706360 | cell-based format |
| CHEMBL3704086 |  |
IC50 | = | 7.0 | nM | 499.54 | O=C(CNc1ncnc2ccc(C(F)(F)F)cc12)NC1CN(C2CCC(c3ccccc3O)CC2)C1 | Homo sapiens | CHEMBL3706360 | cell-based format |
| CHEMBL3906803 |  |
IC50 | = | 7.0 | nM | 548.64 | CC(C)c1nc(NCC(=O)NC2CN(C3CCC(O)(c4cncs4)CC3)C2)c2cc(C(F)(F)F)ccc2n1 | Homo sapiens | CHEMBL3706360 | cell-based format |
| CHEMBL3966845 |  |
IC50 | = | 8.0 | nM | 520.58 | Cc1nc(NCC(=O)NC2CN(C3CCC(O)(c4cncs4)CC3)C2)c2cc(C(F)(F)F)ccc2n1 | Homo sapiens | CHEMBL3706360 | cell-based format |
| CHEMBL3704027 |  |
IC50 | = | 9.0 | nM | 479.55 | CC(C)C(O)[C@H]1CC[C@@H](N2CC(NC(=O)CNc3ncnc4ccc(C(F)(F)F)cc34)C2)CC1 | Homo sapiens | CHEMBL3706360 | cell-based format |
| CHEMBL3704028 |  |
IC50 | = | 9.0 | nM | 433.48 | C=C[C@H]1CC[C@@H](N2CC(NC(=O)CNc3ncnc4ccc(C(F)(F)F)cc34)C2)CC1 | Homo sapiens | CHEMBL3706360 | cell-based format |
| CHEMBL3704029 |  |
IC50 | = | 9.0 | nM | 475.52 | O=C(CNc1ncnc2ccc(C(F)(F)F)cc12)NC1CN([C@H]2CC[C@@H](C3C=CCO3)CC2)C1 | Homo sapiens | CHEMBL3706360 | cell-based format |
| CHEMBL3704079 |  |
IC50 | = | 9.0 | nM | 548.59 | NC(=O)c1cc(NCC(=O)NC2CN([C@H]3CC[C@@](O)(c4cncs4)CC3)C2)c2cc(C(F)(F)F)ccc2n1 | Homo sapiens | CHEMBL3706360 | cell-based format |
| CHEMBL3704087 |  |
IC50 | = | 9.0 | nM | 499.54 | Nc1ccc(C2CCC(N3CC(NC(=O)CNc4ncnc5ccc(C(F)(F)F)cc45)C3)CC2)nc1 | Homo sapiens | CHEMBL3706360 | cell-based format |
| CHEMBL3659041 |  |
IC50 | = | 9.2 | nM | 506.55 | O=C(CNc1cnnc2ccc(C(F)(F)F)cc12)NC1CN([C@H]2CC[C@@](O)(c3cncs3)CC2)C1 | Homo sapiens | CHEMBL3706360 | cell-based format |
| CHEMBL3704032 |  |
IC50 | = | 10.0 | nM | 504.56 | O=C(CNc1ncnc2ccc(C(F)(F)F)cc12)NC1CN([C@H]2CC[C@@H](C3CCCC(=O)N3)CC2)C1 | Homo sapiens | CHEMBL3706360 | cell-based format |
| CHEMBL3704037 |  |
IC50 | = | 10.0 | nM | 497.59 | CSCC(O)[C@H]1CC[C@@H](N2CC(NC(=O)CNc3ncnc4ccc(C(F)(F)F)cc34)C2)CC1 | Homo sapiens | CHEMBL3706360 | cell-based format |
| CHEMBL3704092 |  |
IC50 | = | 11.0 | nM | 514.55 | Cc1ccc([C@]2(O)CC[C@H](N3CC(NC(=O)CNc4ncnc5ccc(C(F)(F)F)cc45)C3)CC2)cn1 | Homo sapiens | CHEMBL3706360 | cell-based format |
| CHEMBL3704030 |  |
IC50 | = | 12.0 | nM | 502.54 | O=C1C=CCC([C@H]2CC[C@@H](N3CC(NC(=O)CNc4ncnc5ccc(C(F)(F)F)cc45)C3)CC2)N1 | Homo sapiens | CHEMBL3706360 | cell-based format |
| CHEMBL3704116 |  |
IC50 | = | 13.0 | nM | 479.5 | CCOC(=O)[C@H]1CC[C@@H](N2CC(NC(=O)CNc3ncnc4ccc(C(F)(F)F)cc34)C2)CC1 | Homo sapiens | CHEMBL3706360 | cell-based format |