O00418 | EF2K_HUMAN | Eukaryotic elongation factor 2 kinase (EEF2K)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF02816 | Alpha_kinase - Alpha-kinase family | 139~318 |
3D structures mapped by conservation among orthologs
[ Domain: "ARM repeat" // Sel1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5174034 |  |
IC50 | = | 32.0 | nM | 345.39 | O=C(Nc1ccc(F)cc1F)N1CCCN(Cc2ccccc2)CC1 | Homo sapiens | CHEMBL5148040 | single protein format |
| CHEMBL1683636 |  |
IC50 | = | 60.0 | nM | 524.58 | CCCCCCCCCCCCCCCC[n+]1ccn(Cc2ccccc2)c1C.[I-] | Homo sapiens | CHEMBL4709071 | single protein format |
| CHEMBL4171806 |  |
IC50 | = | 60.0 | nM | 526.59 | CCCCCCCCCCCCCCCC[N+]1=C(C)N(Cc2ccccc2)CC1.[I-] | Homo sapiens | CHEMBL4143179 | assay format |
| CHEMBL5204448 |  |
IC50 | = | 69.0 | nM | 391.3 | O=S(=O)(c1ccc(Cl)cc1)C1(S(=O)(=O)c2ccc(Cl)cc2)CC1 | Homo sapiens | CHEMBL5148040 | single protein format |
| CHEMBL1094018 |  |
IC50 | = | 110.0 | nM | 408.96 | Nc1ncnc2c1sc1nc3c(c(-c4ccc(Cl)cc4)c12)CCCCCCC3 | Homo sapiens | CHEMBL1111547 | assay format |
| CHEMBL1092820 |  |
IC50 | = | 170.0 | nM | 355.46 | NC(=O)c1sc2nc3c(c(-c4ccco4)c2c1N)CCCCCCC3 | Homo sapiens | CHEMBL1111547 | assay format |
| CHEMBL1091317 |  |
IC50 | = | 220.0 | nM | 341.44 | Nc1ncnc2c1sc1nc(N3CCOCC3)c3c(c12)CCCC3 | Homo sapiens | CHEMBL1111547 | assay format |
| CHEMBL5194579 |  |
IC50 | = | 230.0 | nM | 277.37 | O=C1CC(c2ccccc2)c2cccc(N3CCCC3)c21 | Homo sapiens | CHEMBL5148040 | single protein format |
| CHEMBL1094026 |  |
IC50 | = | 280.0 | nM | 375.88 | NC(=O)c1sc2nc3c(c(-c4ccc(Cl)o4)c2c1N)CCCCCC3 | Homo sapiens | CHEMBL1111547 | assay format |
| CHEMBL1089019 |  |
IC50 | = | 300.0 | nM | 409.43 | NC(=O)c1sc2nc3c(c(-c4ccc(C(F)(F)F)o4)c2c1N)CCCCCC3 | Homo sapiens | CHEMBL1111547 | assay format |
| CHEMBL4776943 |  |
IC50 | = | 310.0 | nM | 310.3 | Cc1ccc(C2=NC(C)(O)CC(C(C)C)[Se]2)cc1 | Homo sapiens | CHEMBL4709071 | single protein format |
| CHEMBL1091829 |  |
IC50 | = | 320.0 | nM | 367.47 | NC(=O)c1sc2nc3c(c(/C=C/c4ccco4)c2c1N)CCCCCC3 | Homo sapiens | CHEMBL1111547 | assay format |
| CHEMBL1091074 |  |
IC50 | = | 330.0 | nM | 391.5 | NC(=O)c1sc2nc3c(c(-c4cc5ccccc5o4)c2c1N)CCCCCC3 | Homo sapiens | CHEMBL1111547 | assay format |
| CHEMBL1091450 |  |
IC50 | = | 350.0 | nM | 364.47 | Nc1ncnc2c1sc1nc3c(c(-c4ccco4)c12)CCCCCCC3 | Homo sapiens | CHEMBL1111547 | assay format |
| CHEMBL1977874 |  |
IC50 | = | 420.0 | nM | 289.3 | CCn1c(=O)c2cc(C(N)=O)c(N)nc2n(C2CC2)c1=O | Homo sapiens | CHEMBL3373720 | assay format |
| CHEMBL437612 |  |
IC50 | = | 440.0 | nM | 228.25 | Cc1cc(C=C2C(=O)C=CC2=O)cc(C)c1O | Homo sapiens | CHEMBL937076 | single protein format |
| CHEMBL1091830 |  |
IC50 | = | 460.0 | nM | 371.53 | Cc1ccsc1-c1c2c(nc3sc(C(N)=O)c(N)c13)CCCCCC2 | Homo sapiens | CHEMBL1111547 | assay format |
| CHEMBL1094038 |  |
IC50 | = | 640.0 | nM | 341.44 | NC(=O)c1sc2nc3c(c(-c4ccco4)c2c1N)CCCCCC3 | Homo sapiens | CHEMBL1111547 | assay format |
| CHEMBL1091075 |  |
IC50 | = | 660.0 | nM | 369.49 | CCc1ccc(-c2c3c(nc4sc(C(N)=O)c(N)c24)CCCCCC3)o1 | Homo sapiens | CHEMBL1111547 | assay format |
| CHEMBL4281348 |  |
IC50 | = | 762.0 | nM | 434.85 | CCNc1cc(-c2ccc(NC(=O)Nc3cccc(Cl)c3)cc2C(F)(F)F)ccn1 | Homo sapiens | CHEMBL4254239 | single protein format |