O00311 | CDC7_HUMAN | Cell division cycle 7-related protein kinase (CDC7)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 59~207 | |
| PF00069 | Pkinase - Protein kinase domain | 366~462 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3972853 |  |
IC50 | = | 1.0 | nM | 337.4 | Cc1ccsc1C/N=C1/CC(=O)/C(=C/c2c[nH]c3ncccc23)O1 | Homo sapiens | CHEMBL3705143 | single protein format |
| CHEMBL3670786 |  |
IC50 | = | 1.0 | nM | 343.35 | O=C1C/C(=N/c2ccc3[nH]ncc3c2)O/C1=C\c1c[nH]c2ncccc12 | Homo sapiens | CHEMBL3705143 | single protein format |
| CHEMBL445340 |  |
IC50 | = | 1.0 | nM | 271.32 | CC(C)C1CNC(=O)c2cc(-c3ccnc(N)n3)[nH]c21 | Homo sapiens | CHEMBL1019871 | single protein format |
| CHEMBL524266 |  |
IC50 | = | 2.0 | nM | 275.29 | Nc1nccc(-c2cc3c([nH]2)[C@@H](CCF)CNC3=O)n1 | Homo sapiens | CHEMBL1019871 | single protein format |
| CHEMBL399492 |  |
IC50 | = | 2.0 | nM | 237.26 | O=C1NCCc2[nH]c3c(ccc4cnccc43)c21 | Homo sapiens | CHEMBL944978 | single protein format |
| CHEMBL1271443 |  |
IC50 | = | 2.0 | nM | 358.2 | NC(=O)c1cc(-c2nc(N)ncc2Br)[nH]c1-c1ccccc1 | Homo sapiens | CHEMBL1274171 | single protein format |
| CHEMBL496961 |  |
IC50 | = | 2.0 | nM | 256.31 | CC1(C)CNC(=O)c2cc(-c3ccnc(N)c3)[nH]c21 | Homo sapiens | CHEMBL1019871 | single protein format |
| CHEMBL4114785 |  |
IC50 | = | 2.0 | nM | 335.34 | Cc1cc(F)ccc1/N=C1/CC(=O)/C(=C/c2c[nH]c3ncccc23)O1 | Homo sapiens | CHEMBL3705143 | single protein format |
| CHEMBL495757 |  |
IC50 | = | 2.0 | nM | 241.29 | CCC1CNC(=O)c2cc(-c3ccncc3)[nH]c21 | Homo sapiens | CHEMBL1019871 | single protein format |
| CHEMBL497995 |  |
IC50 | = | 2.0 | nM | 283.34 | Nc1nccc(-c2cc3c([nH]2)C(C2CCC2)CNC3=O)n1 | Homo sapiens | CHEMBL1019871 | single protein format |
| CHEMBL447369 |  |
IC50 | = | 2.0 | nM | 259.28 | O=C1NCC(CCF)c2[nH]c(-c3ccncc3)cc21 | Homo sapiens | CHEMBL1019871 | single protein format |
| CHEMBL3951396 |  |
IC50 | = | 2.0 | nM | 409.83 | CCOC(=O)C1C(=O)/C(=C/c2c[nH]c3ncccc23)O/C1=N\c1ccccc1Cl | Homo sapiens | CHEMBL3705143 | single protein format |
| CHEMBL501724 |  |
IC50 | = | 3.0 | nM | 278.31 | Cc1cc(-c2cc(-c3ccccc3)[nH]c(=O)n2)ccc1O | Homo sapiens | CHEMBL998766 | single protein format |
| CHEMBL3670781 |  |
IC50 | = | 3.0 | nM | 384.39 | CCOC(=O)C1C(=O)/C(=C/c2c[nH]c3ncccc23)O/C1=N\N1CCOCC1 | Homo sapiens | CHEMBL3705143 | single protein format |
| CHEMBL3670782 |  |
IC50 | = | 3.0 | nM | 463.49 | Cc1cc(OCCO)ccc1/N=C1\O/C(=C\c2c[nH]c3ncccc23)C(=O)C1C(=O)OC(C)C | Homo sapiens | CHEMBL3705143 | single protein format |
| CHEMBL3903885 |  |
IC50 | = | 3.0 | nM | 439.86 | COCCOC(=O)C1C(=O)/C(=C/c2c[nH]c3ncccc23)O/C1=N\c1ccccc1Cl | Homo sapiens | CHEMBL3705143 | single protein format |
| CHEMBL3924774 |  |
IC50 | = | 3.0 | nM | 423.4 | O=C(OCCCO)C1C(=O)/C(=C/c2c[nH]c3ncccc23)O/C1=N\c1ccc(F)cc1 | Homo sapiens | CHEMBL3705143 | single protein format |
| CHEMBL496772 |  |
IC50 | = | 3.0 | nM | 269.35 | CC(C)CC1Cc2[nH]c(-c3ccncc3)cc2C(=O)N1 | Homo sapiens | CHEMBL1019871 | single protein format |
| CHEMBL4114693 |  |
IC50 | = | 3.0 | nM | 448.48 | CCOC(=O)C1C(=O)/C(=C/c2c[nH]c3ncccc23)O/C1=N\c1ccc(NCCO)cc1C | Homo sapiens | CHEMBL3705143 | single protein format |
| CHEMBL443669 |  |
IC50 | = | 3.0 | nM | 275.29 | Nc1nccc(-c2cc3c([nH]2)C(CCF)CNC3=O)n1 | Homo sapiens | CHEMBL1019871 | single protein format |