O00255 | MEN1_HUMAN | Menin (MEN1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF05053 | Menin - Menin | 3~499 | |
| PF05053 | Menin - Menin | 548~608 |
3D structures mapped by conservation among orthologs
[ Domain: "ARM repeat" // Menin_2nd ]
[ Domain: "Cysteine proteinases" // Menin_1st ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4211366 |  |
IC50 | = | 1.0 | nM | 352.48 | O=c1cccc2n1[C@@H]1C[C@H](C2)CN(CC(O)CCCc2ccccc2)C1 | Homo sapiens | CHEMBL4186850 | single protein format |
| CHEMBL4216801 |  |
IC50 | = | 3.6 | nM | 597.67 | Cc1c(CN2CCC(Nc3ncnc4sc(CC(F)(F)F)cc34)CC2)ccc2c1cc(C#N)n2C[C@@H]1CNC(=O)CO1 | Homo sapiens | CHEMBL4189777 | cell-based format |
| CHEMBL4164572 |  |
IC50 | = | 4.0 | nM | 525.62 | NS(=O)(=O)Cc1ccc(CN2CCC3(CCN(c4ncnc5sc(CC(F)(F)F)cc45)C3)C2)cc1 | Homo sapiens | CHEMBL4149708 | assay format |
| CHEMBL4585198 |  |
IC50 | = | 6.0 | nM | 598.86 | CCN1Cc2ccccc2C(C2CCCC2)(C2CCN(CC3CN(c4ccc(S(=O)(=O)c5ccncc5)cc4)C3)CC2)C1 | Homo sapiens | CHEMBL4366888 | single protein format |
| CHEMBL4218724 |  |
IC50 | = | 7.5 | nM | 597.67 | Cc1c(CN2CCC(Nc3ncnc4sc(CC(F)(F)F)cc34)CC2)ccc2c1cc(C#N)n2CC1CNC(=O)CO1 | Homo sapiens | CHEMBL4189777 | cell-based format |
| CHEMBL4449199 |  |
IC50 | = | 8.0 | nM | 570.8 | O=S(=O)(c1ccncc1)c1ccc(N2CC(CN3CCC(C4(C5CCCC5)CNCc5ccccc54)CC3)C2)cc1 | Homo sapiens | CHEMBL4366888 | single protein format |
| CHEMBL4174529 |  |
IC50 | = | 10.0 | nM | 525.62 | NS(=O)(=O)Cc1ccc(CN2CCC3(CCN(c4ncnc5cc(CC(F)(F)F)sc45)C3)C2)cc1 | Homo sapiens | CHEMBL4149708 | assay format |
| CHEMBL4174165 |  |
IC50 | = | 10.0 | nM | 499.63 | FC(F)Cc1cc2c(N3CCC4(CCN(Cc5ccc(N6CCOCC6)cc5)C4)C3)ncnc2s1 | Homo sapiens | CHEMBL4149708 | assay format |
| CHEMBL4166615 |  |
IC50 | = | 10.0 | nM | 501.58 | C=CC(=O)Nc1ccc(CN2CCC3(CCN(c4ncnc5sc(CC(F)(F)F)cc45)C3)C2)cc1 | Homo sapiens | CHEMBL4149708 | assay format |
| CHEMBL4163173 |  |
IC50 | = | 10.0 | nM | 569.68 | O=S(=O)(Cc1ccc(CN2CCC3(CCN(c4ncnc5sc(CC(F)(F)F)cc45)C3)C2)cc1)NCCO | Homo sapiens | CHEMBL4149708 | assay format |
| CHEMBL4578509 |  |
IC50 | = | 10.0 | nM | 575.86 | O=S(=O)(c1ccc(N2CC(CN3CCC(C4(C5CCCC5)NCCc5ccccc54)CC3)C2)cc1)C1CCCCC1 | Homo sapiens | CHEMBL4366888 | single protein format |
| CHEMBL4171091 |  |
IC50 | = | 10.0 | nM | 539.65 | CC(c1ccc(CN2CCC3(CCN(c4ncnc5sc(CC(F)(F)F)cc45)C3)C2)cc1)S(N)(=O)=O | Homo sapiens | CHEMBL4149708 | assay format |
| CHEMBL4163807 |  |
IC50 | = | 10.0 | nM | 505.61 | CN(CCO)c1ccc(CN2CCC3(CCN(c4ncnc5sc(CC(F)(F)F)cc45)C3)C2)cc1 | Homo sapiens | CHEMBL4149708 | assay format |
| CHEMBL4516680 |  |
IC50 | = | 11.0 | nM | 584.83 | CN1Cc2ccccc2C(C2CCCC2)(C2CCN(CC3CN(c4ccc(S(=O)(=O)c5ccncc5)cc4)C3)CC2)C1 | Homo sapiens | CHEMBL4366888 | single protein format |
| CHEMBL4458829 |  |
IC50 | = | 11.0 | nM | 511.67 | CNC(=O)O[C@H]1CCC[C@@H]1[C@](C#N)(c1ccccc1)C1CCN(CC2CN(c3ccc(C#N)cc3)C2)CC1 | Homo sapiens | CHEMBL4366888 | single protein format |
| CHEMBL4209476 |  |
IC50 | = | 14.0 | nM | 595.74 | Cc1c(CN2CCC(Nc3ncnc4sc(CC(F)(F)F)cc34)CC2)ccc2c1cc(C#N)n2CCC1CCNCC1 | Homo sapiens | CHEMBL4189777 | cell-based format |
| CHEMBL3780822 |  |
IC50 | = | 14.7 | nM | 564.64 | Cc1c(CN2CCC(Nc3ncnc4sc(CC(F)(F)F)cc34)CC2)ccc2c1cc(C#N)n2Cc1cn[nH]c1 | Homo sapiens | CHEMBL4186852 | single protein format |
| CHEMBL4203695 |  |
IC50 | = | 15.0 | nM | 596.73 | Cc1c(CN2CCC(Nc3ncnc4sc(CC(F)(F)F)cc34)CC2)ccc2c1cc(C#N)n2CCN1CCNCC1 | Homo sapiens | CHEMBL4189777 | cell-based format |
| CHEMBL4476073 |  |
IC50 | = | 17.0 | nM | 570.8 | O=S(=O)(c1ccncc1)c1ccc(N2CC(CN3CCC(C4(C5CCCC5)NCCc5ccccc54)CC3)C2)cc1 | Homo sapiens | CHEMBL4366888 | single protein format |
| CHEMBL4459554 |  |
IC50 | = | 17.0 | nM | 561.84 | O=S(=O)(c1ccc(N2CC(CN3CCC(C4(C5CCCC5)NCCc5ccccc54)CC3)C2)cc1)C1CCCC1 | Homo sapiens | CHEMBL4366888 | single protein format |