O00238 | BMR1B_HUMAN | Bone morphogenetic protein receptor type-1B (BMPR1B)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01064 | Activin_recp - Activin types I and II receptor domain | 30~105 | |
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 204~489 | |
| PF08515 | TGF_beta_GS - Transforming growth factor beta type I GS-motif | 175~202 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL2385582 |  |
IC50 | < | 5.0 | nM | 407.48 | c1ccc2c(-c3cnn4cc(-c5ccc(N6CCOCC6)cc5)cnc34)ccnc2c1 | Homo sapiens | CHEMBL2390522 | single protein format |
| CHEMBL2385596 |  |
IC50 | < | 5.0 | nM | 420.52 | CN1CCN(c2ccc(-c3cnc4c(-c5ccnc6ccccc56)cnn4c3)cc2)CC1 | Homo sapiens | CHEMBL2390522 | single protein format |
| CHEMBL4740381 |  |
IC50 | = | 18.4 | nM | 419.53 | Cc1cc(-c2cnc3cc(-c4ccc(N5CCNCC5)cc4)ccn23)c2ccccc2n1 | Homo sapiens | CHEMBL4727758 | single protein format |
| CHEMBL4788859 |  |
IC50 | = | 29.4 | nM | 437.52 | Cc1cc(-c2cnc3cc(-c4ccc(N5CCNCC5)cc4)ccn23)c2cc(F)ccc2n1 | Homo sapiens | CHEMBL4727758 | single protein format |
| CHEMBL4786529 |  |
IC50 | = | 40.9 | nM | 455.51 | Cc1cc(-c2cnc3cc(-c4ccc(N5CCNCC5)cc4)ccn23)c2cc(F)cc(F)c2n1 | Homo sapiens | CHEMBL4727758 | single protein format |
| CHEMBL5083143 |  |
IC50 | = | 41.0 | nM | 406.49 | c1ccc2c(-c3coc4cc(-c5ccc(N6CCNCC6)cc5)cnc34)ccnc2c1 | Homo sapiens | CHEMBL5478941 | single protein format |
| CHEMBL2385597 |  |
IC50 | = | 47.6 | nM | 380.45 | CC(C)Oc1ccc(-c2cnc3c(-c4ccnc5ccccc45)cnn3c2)cc1 | Homo sapiens | CHEMBL2390522 | single protein format |
| CHEMBL4742906 |  |
IC50 | = | 54.5 | nM | 419.53 | Cc1cc(-c2cnc3cc(-c4ccc(C5CNCCN5)cc4)ccn23)c2ccccc2n1 | Homo sapiens | CHEMBL4727758 | single protein format |
| CHEMBL511563 |  |
IC50 | = | 56.9 | nM | 352.4 | COc1ccc(-c2cnc3c(-c4ccnc5ccccc45)cnn3c2)cc1 | Homo sapiens | CHEMBL2390522 | single protein format |
| CHEMBL513147 |  |
IC50 | = | 60.0 | nM | 406.49 | c1ccc2c(-c3cnn4cc(-c5ccc(N6CCNCC6)cc5)cnc34)ccnc2c1 | Homo sapiens | CHEMBL2390522 | single protein format |
| CHEMBL2385579 |  |
IC50 | = | 60.9 | nM | 346.39 | c1cc(N2CCOCC2)ccc1-c1cnc2c(-c3cn[nH]c3)cnn2c1 | Homo sapiens | CHEMBL2390522 | single protein format |
| CHEMBL4517408 |  |
IC50 | = | 68.0 | nM | 419.53 | COc1cc(-c2cncc(-c3ccc(N4CCNCC4)cc3)c2C)cc(OC)c1OC | Homo sapiens | CHEMBL4626191 | single protein format |
| CHEMBL4548795 |  |
IC50 | = | 88.0 | nM | 462.57 | COc1cc(-c2cncc(-c3ccc(N4CCN(C(C)C)CC4)cc3)c2C)cc(F)c1C(N)=O | Homo sapiens | CHEMBL5478955 | single protein format |
| CHEMBL2385591 |  |
IC50 | = | 92.9 | nM | 406.49 | c1cc(-c2cnn3cc(-c4ccc(N5CCNCC5)cc4)cnc23)c2cccnc2c1 | Homo sapiens | CHEMBL2390522 | single protein format |
| CHEMBL2385600 |  |
IC50 | = | 102.0 | nM | 291.31 | COc1ccc(-c2cnc3c(-c4cn[nH]c4)cnn3c2)cc1 | Homo sapiens | CHEMBL2390522 | single protein format |
| CHEMBL1078178 |  |
IC50 | = | 107.0 | nM | 414.47 | N#CCNC(=O)c1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1 | Homo sapiens | CHEMBL3889145 | single protein format |
| CHEMBL2385586 |  |
IC50 | = | 129.0 | nM | 345.41 | c1cc(N2CCNCC2)ccc1-c1cnc2c(-c3cn[nH]c3)cnn2c1 | Homo sapiens | CHEMBL2390522 | single protein format |
| CHEMBL4778971 |  |
IC50 | = | 188.0 | nM | 455.51 | Cc1cc(-c2cnc3cc(-c4ccc(C5CNCCN5)cc4)ccn23)c2cc(F)cc(F)c2n1 | Homo sapiens | CHEMBL4727758 | single protein format |
| CHEMBL478629 |  |
IC50 | = | 235.0 | nM | 399.5 | c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)ccn1 | Homo sapiens | CHEMBL2390522 | single protein format |