O00141 | SGK1_HUMAN | Serine/threonine-protein kinase Sgk1 (SGK1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 98~355 | |
| PF00433 | Pkinase_C - Protein kinase C terminal domain | 376~423 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5070612 |  |
IC50 | = | 1.0 | nM | 534.98 | Cc1n[nH]c2nc(-c3ccc(NS(=O)(=O)c4cc(Cl)ccc4F)cc3)nc(OC3CCNCC3F)c12 | Homo sapiens | CHEMBL5043745 | assay format |
| CHEMBL5074684 |  |
IC50 | = | 1.0 | nM | 532.99 | Cc1n[nH]c2nc(-c3ccc(NS(=O)(=O)c4cc(Cl)ccc4F)cc3)nc(OCC3(CN)COC3)c12 | Homo sapiens | CHEMBL5043745 | assay format |
| CHEMBL5088069 |  |
IC50 | = | 1.0 | nM | 521.96 | Cc1n[nH]c2nc(-c3ccc(NS(=O)(=O)c4cc(Cl)ccc4F)cc3)nc(OCC(CO)CO)c12 | Homo sapiens | CHEMBL5043745 | assay format |
| CHEMBL3356029 |  |
IC50 | = | 1.0 | nM | 450.42 | Nc1n[nH]c2cc(-c3ccc(NS(=O)(=O)c4cc(C(F)(F)F)ccc4F)cc3)ccc12 | Homo sapiens | CHEMBL3375440 | single protein format |
| CHEMBL5085476 |  |
IC50 | = | 1.0 | nM | 552.97 | Cc1n[nH]c2nc(-c3ccc(NS(=O)(=O)c4cc(Cl)ccc4F)cc3)nc(OC3CCNCC3(F)F)c12 | Homo sapiens | CHEMBL5043745 | assay format |
| CHEMBL5081869 |  |
IC50 | = | 1.0 | nM | 516.99 | Cc1n[nH]c2nc(-c3ccc(NS(=O)(=O)c4cc(Cl)ccc4F)cc3)nc(OC3CCCNC3)c12 | Homo sapiens | CHEMBL5043745 | assay format |
| CHEMBL5083625 |  |
IC50 | = | 1.0 | nM | 516.99 | Cc1n[nH]c2nc(-c3ccc(NS(=O)(=O)c4cc(Cl)ccc4F)cc3)nc(OC3CCNCC3)c12 | Homo sapiens | CHEMBL5043745 | assay format |
| CHEMBL3356030 |  |
IC50 | < | 1.0 | nM | 382.42 | Nc1n[nH]c2cc(-c3ccc(NS(=O)(=O)c4ccccc4F)cc3)ccc12 | Homo sapiens | CHEMBL3375440 | single protein format |
| CHEMBL5075362 |  |
IC50 | = | 1.0 | nM | 543.4 | O=C(NCc1ncn[nH]1)c1cc(-c2ccc(NS(=O)(=O)c3cccc(Cl)c3Cl)cc2)nc2[nH]ncc12 | Homo sapiens | CHEMBL5043745 | assay format |
| CHEMBL5087657 |  |
IC50 | = | 1.0 | nM | 585.52 | O=C(NC1CCN(CC2CC2)C1)c1cc(-c2ccc(NS(=O)(=O)c3cccc(Cl)c3Cl)cc2)nc2[nH]ncc12 | Homo sapiens | CHEMBL5043745 | assay format |
| CHEMBL5078023 |  |
IC50 | < | 1.0 | nM | 531.43 | O=C(N[C@@H]1CCNC1)c1cc(-c2ccc(NS(=O)(=O)c3cccc(Cl)c3Cl)cc2)nc2[nH]ncc12 | Homo sapiens | CHEMBL5043745 | assay format |
| CHEMBL5077567 |  |
IC50 | < | 1.0 | nM | 505.39 | NCCNC(=O)c1cc(-c2ccc(NS(=O)(=O)c3cccc(Cl)c3Cl)cc2)nc2[nH]ncc12 | Homo sapiens | CHEMBL5043745 | assay format |
| CHEMBL5071237 |  |
IC50 | < | 1.0 | nM | 531.43 | CN1CC(NC(=O)c2cc(-c3ccc(NS(=O)(=O)c4cccc(Cl)c4Cl)cc3)nc3[nH]ncc23)C1 | Homo sapiens | CHEMBL5043745 | assay format |
| CHEMBL5075992 |  |
IC50 | = | 1.0 | nM | 462.32 | NC(=O)c1cc(-c2ccc(NS(=O)(=O)c3cccc(Cl)c3Cl)cc2)nc2[nH]ncc12 | Homo sapiens | CHEMBL5043745 | assay format |
| CHEMBL5093306 |  |
IC50 | = | 1.0 | nM | 575.48 | O=C(NC1CCN(CCO)C1)c1cc(-c2ccc(NS(=O)(=O)c3cccc(Cl)c3Cl)cc2)nc2[nH]ncc12 | Homo sapiens | CHEMBL5043745 | assay format |
| CHEMBL5087162 |  |
IC50 | = | 1.0 | nM | 545.04 | Cc1n[nH]c2nc(-c3ccc(NS(=O)(=O)c4cc(Cl)ccc4F)cc3)nc(OCC3CN(C(C)C)C3)c12 | Homo sapiens | CHEMBL5043745 | assay format |
| CHEMBL3355031 |  |
IC50 | = | 1.5 | nM | 413.43 | COc1nc(-c2ccc(NS(=O)(=O)c3cc(C)ccc3F)cc2)nc2[nH]ncc12 | Homo sapiens | CHEMBL3379050 | single protein format |
| CHEMBL5086345 |  |
IC50 | < | 2.0 | nM | 490.95 | Cc1n[nH]c2nc(-c3ccc(NS(=O)(=O)c4cc(Cl)ccc4F)cc3)nc(OCCCN)c12 | Homo sapiens | CHEMBL5043745 | assay format |
| CHEMBL5081330 |  |
IC50 | = | 2.0 | nM | 587.12 | Cc1n[nH]c2nc(-c3ccc(NS(=O)(=O)c4cc(Cl)ccc4F)cc3)nc(OC3CC(C)(C)N(C)C(C)(C)C3)c12 | Homo sapiens | CHEMBL5043745 | assay format |
| CHEMBL5071544 |  |
IC50 | = | 2.0 | nM | 532.99 | Cc1n[nH]c2nc(-c3ccc(NS(=O)(=O)c4cc(Cl)ccc4F)cc3)nc(OCC3CNCCO3)c12 | Homo sapiens | CHEMBL5043745 | assay format |