A5PKW4 | PSD1_HUMAN | PH and SEC7 domain-containing protein 1 (PSD)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01369 | Sec7 - Sec7 domain | 557~707 | |
| PF15410 | PH_9 - Pleckstrin homology domain | 758~869 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4574541 |  |
IC50 | = | 250.0 | nM | 501.3 | O=c1cc(-c2cccc(-c3cccnc3)c2)[nH]c2c(-c3ccc(Cl)c(Cl)c3)c(C(F)(F)F)nn12 | Homo sapiens | CHEMBL4476963 | assay format |
| CHEMBL4560033 |  |
IC50 | = | 330.0 | nM | 552.29 | O=c1cc(-c2cccc(Oc3cc(F)cc(F)c3)c2)[nH]c2c(-c3ccc(Cl)c(Cl)c3)c(C(F)(F)F)nn12 | Homo sapiens | CHEMBL4476963 | assay format |
| CHEMBL4525424 |  |
IC50 | = | 500.0 | nM | 508.89 | O=C(Nc1ccc(-c2cc(=O)n3nc(C(F)(F)F)c(-c4ccc(Cl)cc4)c3[nH]2)cc1)c1ccccc1 | Homo sapiens | CHEMBL4476963 | assay format |
| CHEMBL4574204 |  |
IC50 | = | 520.0 | nM | 516.31 | O=c1cc(-c2cccc(Oc3ccccc3)c2)[nH]c2c(-c3ccc(Cl)c(Cl)c3)c(C(F)(F)F)nn12 | Homo sapiens | CHEMBL4476963 | assay format |
| CHEMBL4540870 |  |
IC50 | = | 560.0 | nM | 445.54 | CCC(C)(C)C1CCc2c(sc3c2C(=O)NC(c2cc(OC)c(O)c([N+](=O)[O-])c2)N3)C1 | Homo sapiens | CHEMBL4476963 | assay format |
| CHEMBL4585299 |  |
IC50 | = | 580.0 | nM | 477.31 | O=c1cc(-c2ccc([N+](=O)[O-])cc2)[nH]c2c(-c3ccc(Cl)c(Cl)c3)c(-c3ccccc3)nn12 | Homo sapiens | CHEMBL4476963 | assay format |
| CHEMBL4534219 |  |
IC50 | = | 660.0 | nM | 516.31 | O=c1cc(-c2ccc(Oc3ccccc3)cc2)[nH]c2c(-c3ccc(Cl)c(Cl)c3)c(C(F)(F)F)nn12 | Homo sapiens | CHEMBL4476963 | assay format |
| CHEMBL4555543 |  |
IC50 | = | 660.0 | nM | 469.21 | O=c1cc(-c2ccc([N+](=O)[O-])cc2)[nH]c2c(-c3ccc(Cl)c(Cl)c3)c(C(F)(F)F)nn12 | Homo sapiens | CHEMBL4476963 | assay format |
| CHEMBL4540598 |  |
IC50 | = | 670.0 | nM | 502.76 | O=c1cc(-c2ccc([N+](=O)[O-])cc2)[nH]c2c(-c3ccc(Cl)c(C(F)(F)F)c3)c(C(F)(F)F)nn12 | Homo sapiens | CHEMBL4476963 | assay format |
| CHEMBL4559227 |  |
IC50 | = | 840.0 | nM | 438.24 | O=c1cc(Cc2ccccc2)[nH]c2c(-c3ccc(Cl)c(Cl)c3)c(C(F)(F)F)nn12 | Homo sapiens | CHEMBL4476963 | assay format |
| CHEMBL4531207 |  |
IC50 | = | 880.0 | nM | 469.21 | O=c1c(Cl)c(-c2ccc([N+](=O)[O-])cc2)[nH]c2c(-c3ccc(Cl)cc3)c(C(F)(F)F)nn12 | Homo sapiens | CHEMBL4476963 | assay format |
| CHEMBL4546661 |  |
IC50 | = | 960.0 | nM | 442.86 | O=c1cc(-c2ccc([N+](=O)[O-])cc2)[nH]c2c(-c3ccc(Cl)cc3)c(-c3ccccc3)nn12 | Homo sapiens | CHEMBL4476963 | assay format |
| CHEMBL4591591 |  |
IC50 | = | 960.0 | nM | 480.88 | Cc1ccc(-c2cccc(-c3cc(=O)n4nc(C(F)(F)F)c(-c5ccc(Cl)cc5)c4[nH]3)c2)cn1 | Homo sapiens | CHEMBL4476963 | assay format |
| CHEMBL4574371 |  |
IC50 | = | 980.0 | nM | 424.21 | O=c1c(Cl)c(-c2ccccc2)[nH]c2c(-c3ccc(Cl)cc3)c(C(F)(F)F)nn12 | Homo sapiens | CHEMBL4476963 | assay format |
| CHEMBL4535892 |  |
IC50 | = | 1000.0 | nM | 488.37 | O=c1cc(-c2cccc(Oc3ccccc3)c2)[nH]c2c(-c3ccc(Cl)c(Cl)c3)c(C3CC3)nn12 | Homo sapiens | CHEMBL4476963 | assay format |