A4D1B5 | GSAP_HUMAN | Gamma-secretase-activating protein (GSAP)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF14959 | GSAP-16 - gamma-Secretase-activating protein C-term | 642~749 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3703681 |  |
IC50 | = | 1.0 | nM | 535.06 | O=C(COc1ccc(F)cc1)Nc1ccc2c(c1)CC1CCC(C2)C1NS(=O)(=O)c1ccc(Cl)s1 | Homo sapiens | CHEMBL3705978 | single protein format |
| CHEMBL3703680 |  |
IC50 | = | 1.2 | nM | 490.51 | CC(NC(=O)Cc1cc(F)cc(F)c1)C(=O)NC1N=C(c2ccccc2)c2ccccc2N(C)C1=O | Homo sapiens | CHEMBL3705978 | single protein format |
| CHEMBL1770916 |  |
IC50 | = | 6.2 | nM | 489.66 | CCC[C@H](N[C@H]1CCc2cc(F)cc(F)c2C1)C(=O)Nc1cn(C(C)(C)CNCC(C)(C)C)cn1 | Homo sapiens | CHEMBL5227263 | single protein format |